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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research on Regenerative Medicine submission deadline 18 May 2024 | 4 articles | Viewed by 5269 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardiovascular Diseases: Molecular Mechanisms and Potential Therapy
edited by
submission deadline 20 May 2024 | 16 articles | Viewed by 21514 | Submission Open
Keywords: cardiovascular diseases; pathogenic mechanisms; genetics; cardiomyopathy; myocardial infarction; cardiac fibrosis; pharmacogenomics; drug discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mechanisms of Heavy Metal Toxicity 2.0
edited by
submission deadline 20 May 2024 | 9 articles | Viewed by 14993 | Submission Open
Keywords: heavy metal; metal compound; metallothionein; cellular defense mechanism; metal transporter  
(This special issue belongs to the Section Molecular Toxicology)
Recent Advances in Autoimmune and Inflammatory Disorders
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 13582 | Submission Open
Keywords: autoimmunity; autoimmune disease; inflammation; inflammatory disease; cellular pathways; molecular mechanisms; pathogenesis; therapy
(This special issue belongs to the Section Molecular Immunology)
Novel Molecular Research in Skin Inflammation submission deadline 20 May 2024 | 5 articles | Viewed by 12935 | Submission Open
Keywords: immune-mediated skin diseases; psoriasis; suppurative hidradenitis; atopic dermatitis; acne vulgaris; acne rosacea; lichen sclerosus; chronic spontaneous urticaria; allergic contact eczema; neutrophilic dermatoses; systemic sclerosis; bullous diseases; chronic graft versus host diseases
(This special issue belongs to the Section Molecular Immunology)
Stem Cells in Health and Disease 2.0 submission deadline 20 May 2024 | 10 articles | Viewed by 11562 | Submission Open
Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity
(This special issue belongs to the Section Molecular Biology)
Sympathetic Nerves and Cardiovascular Diseases 2.0
edited by and
submission deadline 20 May 2024 | 4 articles | Viewed by 11400 | Submission Open
Keywords: sympathetic nerve activity; renal denervation; heart disease; stroke; atherosclerosis; hypertension; vascular remodeling; diabetes; metabolic syndrome; kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pharmacogenetics and Personalized Medicine 3.0 submission deadline 20 May 2024 | 7 articles | Viewed by 11309 | Submission Open
Keywords: pharmacogenetics and pharmacogenomics; personalized medicine; lncRNA; miRNA; circRNA; methylation; epigenetics; microbiome; liquid biopsy; circulating biomarkers
(This special issue belongs to the Section Molecular Pharmacology)
A Molecular Perspective on Reproductive Health submission deadline 20 May 2024 | 10 articles | Viewed by 10152 | Submission Open
Keywords: reproductive function; molecular bases; male; female; reproductive pathology; reproductive physiology
(This special issue belongs to the Section Biochemistry)
Molecular Advances in Ovarian Cancer
edited by
submission deadline 20 May 2024 | 7 articles | Viewed by 9275 | Submission Open
Keywords: pathogenesis; tumor microenvironment; ovarian cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Gut Microbiota Derived Metabolites in Cardiovascular Health and Disease
edited by Zeneng Wang
submission deadline 20 May 2024 | 4 articles | Viewed by 9082 | Submission Open
Keywords: gut microbiota-derived metabolites such as: short-chain fatty acids; trimethylamine n-oxide; amide lipid; aromatic amino acid derivatives; polyamines; hydrogen sulfide; lipopolysaccharide; polyphenols; secondary bile acids; receptor recognition and signal transduction induced by metabolites; metabolites initiating atherosclerosis; microbial enzymes catalyzing biosynthesis of the metabolites; inhibitors; prebiotic and probiotic modulation of the metabolite production; transcriptomic; proteomic; metabolic profile changes induced by metabolites
(This special issue belongs to the Section Molecular Microbiology)
Lysophosphatidic Acid Signaling in Health and Disease
edited by and
submission deadline 20 May 2024 | 6 articles | Viewed by 7906 | Submission Open
(This special issue belongs to the Section Biochemistry)
Biomaterials and Their Composites for Biomedical Applications and Beyond submission deadline 20 May 2024 | 5 articles | Viewed by 7758 | Submission Open
Keywords: biomaterials; bio-composite materials; biomedical applications; nerve-tissue engineering; 3D/4D printing; biomedical engineering; nanomedicine; biocompatibility; cytotoxicity factors
(This special issue belongs to the Section Materials Science)
Disorders in Brain Development and Nervous System: Key Molecules and Pathology
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 7639 | Submission Open
Keywords: neurogenesis; neurotrophic factors; synapse formation; neuronal circuit formation; nutrition; specific genes for brain development; pathology of the affected brain
(This special issue belongs to the Section Molecular Neurobiology)
Biosensors for the Early Diagnosis of High-Impact Human Diseases
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 7602 | Submission Open
Keywords: early-stage diagnosis; high-impact human disease; biosensors; liquid biopsy; MEMs; point-of-care platform; artificial-intelligence-assisted diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization 2.0 submission deadline 20 May 2024 | 8 articles | Viewed by 7517 | Submission Open
Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Skin Diseases
edited by
submission deadline 20 May 2024 | 4 articles | Viewed by 7105 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research Progress on Glioblastoma
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 6748 | Submission Open
Keywords: glioblastoma; glioma stem cells; signaling pathways; tumor heterogeneity; tumor microenvironment; microglia; molecular pathways; immunotherapies
(This special issue belongs to the Section Molecular Oncology)
Novel Molecular and Cellular Biology Approaches in the Assessment of Radiation Effects
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 5597 | Submission Open
Keywords: ionizing radiation; cytoplasmic targets of radiation; radiation induced bystander effects; extracellular vesicles; dna damage and repair; biomarkers; miRNA; proteomics; liquid biopsy; radiation carcinogenesis; radiation fibrosis
(This special issue belongs to the Section Molecular Biology)
Molecular and Translational Research on Bone Tumors 2.0 submission deadline 20 May 2024 | 1 articles | Viewed by 5127 | Submission Open
Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Repurposing: Emerging Approaches to Drug Discovery
edited by
submission deadline 20 May 2024 | 3 articles | Viewed by 5116 | Submission Open
Keywords: repurposed drugs; network medicine; systems medicine; drug design; therapeutic strategies; drug repurposing in the era of artificial intelligence; drug repositioning; machine learning
(This special issue belongs to the Section Molecular Informatics)
Research on Bone Cells in Health and Disease
edited by
submission deadline 20 May 2024 | 5 articles | Viewed by 4910 | Submission Open
Keywords: osteoclasts; osteoblasts; osteocytes; osteoporosis; bone tumors; periodontitis; rheumatoid arthritis; bone remodeling
(This special issue belongs to the Section Molecular Biology)
Recent Advances on Fluorine Chemistry
edited by
submission deadline 20 May 2024 | 6 articles | Viewed by 4744 | Submission Open
Keywords: fluorine; оrganofluorine compounds; fluorine-containing building blocks; fluorine introduction; defluorination; fluorocarbons; fluorine NMR; fluorine biocatalysis; trifluoromethyl; lipophilicity; fluorine drugs
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Aldehyde Dehydrogenase in Cancer
edited by and Beata Želazowska-Rutkowska
submission deadline 20 May 2024 | 2 articles | Viewed by 4566 | Submission Open
Keywords: aldehyde dehydrogenase; molecular regulation; molecular tumor pathology; gene polymorphism; gene expression; polymorphism; ALDH isoenzymes; ALDH inhibitors; therapeutic targets; prognosis; cancer stem cell; stem cell marker; biomarker; retinoic acid; oxidative stress; toxic aldehydes; tumor microenvironment; angiogenesis; metastasis
(This special issue belongs to the Section Molecular Oncology)
The Role of Lutein for Human Health submission deadline 20 May 2024 | 3 articles | Viewed by 4509 | Submission Open
Keywords: lutein; retina degeneration; antioxidants; cognitive functions; xanthophylls; carotenoids; AMD
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Biopolymers in Drug and Gene Delivery Systems 3.0
edited by
submission deadline 20 May 2024 | 4 articles | Viewed by 4362 | Submission Open
Keywords: biopolymers; drug delivery; gene delivery; biodegradable polymers; biocompatible polymers; nanomedicine
(This special issue belongs to the Section Macromolecules)
New Targeted Therapeutic Strategies of Multiple Myeloma submission deadline 20 May 2024 | 2 articles | Viewed by 4262 | Submission Open
Keywords: multiple myeloma; uncontrolled proliferation; plasmacells; immunoglobulins; natural drug therapies; immunotherapy; B cells; T cells; immunosuppressive cells; chemotherapeutics; molecular checkpoints; stem cell transplantation (ASCT); current status in MM therapy; new immunomodulatory drug/nutural compounds; monoclonal antibodies; osteoclast activity and bone resorption
(This special issue belongs to the Section Molecular Immunology)
Transcriptional Therapy and Nucleic Acid-Based Therapeutics: From Molecular Targets to Preclinical Studies 2.0
edited by
submission deadline 20 May 2024 | 3 articles | Viewed by 4060 | Submission Open
Keywords: antisense oligonucleotide (ASO); RNA interference (RNAi); CRISPR/Cas9; miRNA; nucleic acid-based therapeutics; long non-coding RNA; splicing modification; transcript-targeted therapy; cancer therapy; genetic diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tissue-Engineered Skin Substitutes: The State-of-the-Art and Future Perspectives
edited by
submission deadline 20 May 2024 | 3 articles | Viewed by 4046 | Submission Open
Keywords: tissue-engineered skin; skin tissue scaffolds; skin substitutes; vascularization; pigmentation; wound healing; 3D printing; full-thickness wounds; clinical perspectives; skin regeneration; scar-free skin healing; immuno-inflammation; hypertrophic scars; keloids macrophages
(This special issue belongs to the Section Molecular Biology)
Metalloproteins: How Metals Shape Protein Structure and Function submission deadline 20 May 2024 | 4 articles | Viewed by 4036 | Submission Open
Keywords: transition metals; metal clusters; structure; catalysis; regulation; electron transfer; metalloenzymes; metal transporters; metal sensors; heavy metal toxicity
(This special issue belongs to the Section Molecular Biophysics)
Cancer Stem Cells in Solid Tumors
edited by
submission deadline 20 May 2024 | 2 articles | Viewed by 4007 | Submission Open
Keywords: CSC characterization; genetic and epigenetic regulators of CSCs; tumor microenvironment; energy/oxidative metabolism; exosomes; microRNAs; treatment resistance; targeting CSCs; differentiation therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic and Epigenetic Determinants of Age-Related Traits: New Challenges and Insights submission deadline 20 May 2024 | 2 articles | Viewed by 3628 | Submission Open
Keywords: genetics; epigenetics; age-related traits; health; chronic diseases; data integration; disease risk; aging
(This special issue belongs to the Section Molecular Genetics and Genomics)
Epigenetics and Beyond: New Advances in Drug Discovery submission deadline 20 May 2024 | 2 articles | Viewed by 3587 | Submission Open
Keywords: epigenetic modifications; epigenetic targets; drug design; drug discovery; cancer; infectious disease; immunology; inflammation; neurological diseases; fibrosis; wound repair and regeneration
(This special issue belongs to the Section Molecular Pharmacology)
Anti-inflammatory and Antioxidant Effects of Natural Bioactive Compounds
edited by
submission deadline 20 May 2024 | 4 articles | Viewed by 3365 | Submission Open
Keywords: anti-inflammation; antioxidant; bioactive materials; immunoregulation; oxidative stress; natural herb extracts; small molecule inhibitor; cell fate modulation; redox regulation; anti-infection
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights in Circadian Rhythm and Metabolism
edited by
submission deadline 20 May 2024 | 3 articles | Viewed by 3344 | Submission Open
Keywords: circadian clock; cell synchrony; bioactive; polyphenol; oxidative stress; metabolic syndrome
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Protein–Ligand Interactions
edited by Dong-Jun Yu
submission deadline 20 May 2024 | 3 articles | Viewed by 3251 | Submission Open
Keywords: drug design; binding specificity; molecular docking; ligand screening; structural biology; protein– protein interactions; protein– ligand interactions; protein– lipid complexes; protein– nucleic acid interactions
(This special issue belongs to the Section Macromolecules)
The Multiple Mechanisms Underlying Neuropathic Pain (III) submission deadline 20 May 2024 | 2 articles | Viewed by 3207 | Submission Open
Keywords: neuropathic pain; nociception; neuroinflammation; sex differences; sex hormones; analgesic response
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Immunotherapy of Soft Tissue and Bone Sarcomas
edited by and
submission deadline 20 May 2024 | 1 articles | Viewed by 3113 | Submission Open
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Cardiac Troponin
edited by
submission deadline 20 May 2024 | 3 articles | Viewed by 3028 | Submission Open
Keywords: cardiac troponins; troponin T and troponin I; myocardial damage; cardiac troponin metabolism; molecular mechanisms; molecular biology; mechanisms of release; transportation of cardiac troponins; mechanisms of elimination; expression of cardiac troponins; regulation of myocardial contraction; post-translational modifications; folding; phosphorylation; glycosylation; proteolysis; myocarditis; Takotsubo syndrome; heart failure; cardiac amyloidosis; acute myocardial infarction; cardiomyopathies; cardiac arrhythmias; pulmonary embolism; diagnostics; non-invasive diagnostics; chronic renal failure  
(This special issue belongs to the Section Molecular Biology)
Advances in Metal Metabolism Research 2.0
edited by
submission deadline 20 May 2024 | 2 articles | Viewed by 2910 | Submission Open
Keywords: molecular evolution; phylogeny; epigenetics; adaptation; gene networks; metal metabolism; metal toxicity; metal homeostasis; metallo-enzymes and metallo-proteins; evolutionary engineering
(This special issue belongs to the Section Biochemistry)
Mitochondrial Dysfunction: A Metabolic, Cardiovascular, Neurodegenerative and Neuromuscular Issue 2.0
edited by , and Claudia Nesti
submission deadline 20 May 2024 | 2 articles | Viewed by 2748 | Submission Open
Keywords: bioenergetics; mitochondrial disorders; biomarkers; OxPhos complexes; mitochondrial DNA; aging; neurodegenerative diseases; cardiovascular diseases; metabolic diseases; therapies to counteract mitochondrial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Beyond Compatibility: Unraveling the Molecular Dynamics of Biomaterial-Host Interactions
edited by Samuel J Lin
submission deadline 20 May 2024 | 2 articles | Viewed by 2506 | Submission Open
Keywords: molecular dynamics; biomaterial‒host interactions; biofilms; bacteria‒host interaction; chronic inflammation; rejection
(This special issue belongs to the Section Materials Science)
Genetics and Epigenetics of Cardiometabolic Diseases
edited by
submission deadline 20 May 2024 | 2 articles | Viewed by 2230 | Submission Open
Keywords: obesity; insulin resistance; diabetes mellitus; cardiovascular diseases; metabolic syndrome; non-alcoholic fatty liver disease; dyslipidaemia; coronary artery disease; chronic kidney disease; hypertension
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms and Therapies of Glioblastoma
edited by , Cristina Pagano and
submission deadline 20 May 2024 | 2 articles | Viewed by 2053 | Submission Open
Keywords: GBM; epigenetics; temozolomide; MGMT
(This special issue belongs to the Section Molecular Oncology)
Conducting and Biodegradable Polymers, a New Concept for Current and Future Biomedical Applications 2.0
edited by
submission deadline 20 May 2024 | 1 articles | Viewed by 2052 | Submission Open
Keywords: biomimetic; biodegradable polymers; conducting polymers; conducting composites and hybrids; synthesis of conducting/biodegradable polymers; structure properties of conducting polymers; polymer synthesis; temperature induced phase separation; biomedical/biological applications; scaffolds; tissue regeneration; biosensing
(This special issue belongs to the Section Macromolecules)
Functional Genomes in Plant Diseases and Pests Management
edited by
submission deadline 20 May 2024 | 1 articles | Viewed by 1948 | Submission Open
Keywords: induced systemic resistance; genetics of plant-microbe interactions; endophytes; phytopathology; functional genomes
(This special issue belongs to the Section Molecular Plant Sciences)
Calpain Family in Health and Diseases: The Road Ahead
edited by
submission deadline 20 May 2024 | 1 articles | Viewed by 1922 | Submission Open
Keywords: chronic inflammation; gene-targeted mice; limited proteolytic cleavage; protein catabolism; cardiometabolic disease; cancer; neurodegenerative disease  
(This special issue belongs to the Section Macromolecules)
Molecular Research on Neuronal Cell Death and Neurogenesis submission deadline 20 May 2024 | 1 articles | Viewed by 1877 | Submission Open
(This special issue belongs to the Section Molecular Neurobiology)
Biopolymers in Nano and Micro Scales for Food Biotechnology Application
edited by
submission deadline 20 May 2024 | 1 articles | Viewed by 1795 | Submission Open
Keywords: polymers; biopolymers; food; micro-scale; nanoscale; composites; biosynthesis; antimicrobial; antifungal; food texture
(This special issue belongs to the Section Macromolecules)
Biological Liquid-Liquid Phase Separation, Biomolecular Condensates, and Membraneless Organelles 2.0 submission deadline 20 May 2024 | 1 articles | Viewed by 1730 | Submission Open
(This special issue belongs to the Section Molecular Biophysics)
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