Special Issue "Lysophosphatidic Acid Signaling in Health and Disease"
Deadline for manuscript submissions: 30 October 2023 | Viewed by 2202
Interests: mitochondria; premature aging; DNA-PKcs; MOMP; lysophosphatidic acid; DNA repair
Interests: cancer biology; angiogenesis; lysophosphatidic acid; lysophosphatidic acid receptors; aryl hydrocarbon receptor; cell aging; bioengineering
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Lysophosphatidic acid (LPA) is a small phospholipid acting as an extracellular lipid-controlling hormone. LPA mediates cellular apoptosis, invasion, and migration by activating its six G protein-coupled receptors (LPARs). LPA and LPARs mediate a broad range of biological effects in many tissue types. An abnormal level of LPA or LPARs has been shown to impair development and individual healthiness. For instance, LPA and LPARs have diverse effects on the development of the nervous system and cardiovascular system. In addition, LPA signaling has been suggested to be a potent signaling pathway with wide-ranging effects on the aging process. Besides, high levels of LPA are found in the tumor microenvironment. LPA has been suggested as an essential factor for the survival and growth of cancer cells. However, the roles of LPA in antitumor therapy remain vastly unexplored. Taken together, this Special Issue aims to update the current understandings about the roles of LPA and LPARs in human health and diseases.
Dr. Wei-Min Chen
Prof. Dr. Hsinyu Lee
Manuscript Submission Information
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