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International Journal of Molecular Sciences runs special issues to create collections of papers on specific topics. The aim is to build a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors who are experts in the subject and oversee the editorial process for papers. Papers published in a Special Issue will be collected together on a dedicated page of the journal website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metals in Biology and Medicine
edited by
submission deadline 15 Oct 2023 | 1 articles | Viewed by 1514 | Submission Open
Keywords: biogenic/abiogenic metal cations; metal binding/selectivity; metalloproteins; enzymes; metal toxicity; health-beneficial effect
(This special issue belongs to the Section Biochemistry)
Protein Misfolding
edited by
submission deadline 15 Oct 2023 | 2 articles | Viewed by 1488 | Submission Open
Keywords: protein misfolding; protein aggregation; genetic mutations; translational errors; abnormal protein modifications; incomplete complex formations
(This special issue belongs to the Section Molecular Biophysics)
Pathogenesis and New Therapeutic Approaches for Fibrosing Diseases—the Skin as a Model System submission deadline 15 Oct 2023 | 1 articles | Viewed by 1458 | Submission Open
Keywords: systemic sclerosis; scleroderma; morphea; fibrosis; pathogenesis; treatment; vasculopathy; collagen; experimental animals; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Approaches for Topical or Transdermal Delivery of Large Molecules
edited by Arvind Bagde and Shawn D Spencer
submission deadline 15 Oct 2023 | 1 articles | Viewed by 1290 | Submission Open
Keywords: topical; insulin; proteins; antibodies; transdermal; microneedle
(This special issue belongs to the Section Molecular Pharmacology)
Microbiota and Sepsis: Interactions and Future Perspectives
edited by
submission deadline 15 Oct 2023 | 1 articles | Viewed by 1180 | Submission Open
Keywords: sepsis; septic shock; microbiome; microbionutritional status; MDR pathogens; therapeutic approaches
(This special issue belongs to the Section Molecular Immunology)
The Road to Tolerance: Molecular Biomarkers for Prediction and Diagnosis of Post-transplant Complications in Liver Transplantation
edited by
submission deadline 15 Oct 2023 | 1 articles | Viewed by 1112 | Submission Open
Keywords: acute rejection; animal models; biliary complications; chronic rejection; cirrhosis; fatty liver; fibrosis; hepatitis; hepatocellular carcinoma; jaundice; NASH; omics; tolerance  
(This special issue belongs to the Section Molecular Immunology)
Advances in Pathogenesis and Treatment of Skin Cancer submission deadline 15 Oct 2023 | 2 articles | Viewed by 955 | Submission Open
Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial– mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights in Heart Failure
edited by
submission deadline 15 Oct 2023 | 1 articles | Viewed by 873 | Submission Open
Keywords: heart failure; neurohormonal activation; natriuretic peptides; myosin; mavacamten; contractile elements; gene and cell therapy; monoclonal genetic disease; autophagy; apoptosis; calcium homeostasis; channelopathies; single cell proteomics; single cell sequencing; RNA seq; genetics; haplo-insufficiency; TNF alpha; TNF receptor; cellular metabolism; mitochondria; mitochondrial damage; caspases; cytokine receptors; pro-inflammatory cytokines; membrane potential; sex-related variation; survival; gene vectors; BAG3; BAG1
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Mechanism and Emerging Materials in Thiamine Catalysis
edited by
submission deadline 15 Oct 2023 | 1 articles | Viewed by 831 | Submission Open
Keywords: transketolase; thiamine diphosphate-dependent enzymes; thiamine catalysis; mass spectrometry; conformational mobility of enzyme molecule
(This special issue belongs to the Section Biochemistry)
Interaction of Nanomaterials with the Immune System 3.0
edited by
submission deadline 15 Oct 2023 | 1 articles | Viewed by 729 | Submission Open
Keywords: nanomaterials; nanoparticles; nanomedicines; immune system; infection; inflammation; allergy; autoimmunity
(This special issue belongs to the Section Molecular Nanoscience)
Gut Microbiota in Human Disease and Health
edited by
submission deadline 15 Oct 2023 | Viewed by 502 | Submission Open
Keywords: gut microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation
(This special issue belongs to the Section Molecular Microbiology)
Research on Bone Cells in Health and Disease
edited by
submission deadline 15 Oct 2023 | Viewed by 363 | Submission Open
Keywords: osteoclasts; osteoblasts; osteocytes; osteoporosis; bone tumors; periodontitis; rheumatoid arthritis; bone remodeling
(This special issue belongs to the Section Molecular Biology)
Antifungal Peptides
edited by
submission deadline 15 Oct 2023 | Viewed by 325 | Submission Open
Keywords: antifungal peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide-delivery strategies; biomedical applications
(This special issue belongs to the Section Molecular Microbiology)
The Function of Stress Proteins in Cell Death and Diseases
edited by
submission deadline 15 Oct 2023 | Viewed by 322 | Submission Open
Keywords: stress response; gene expression; cellular homeostasis; cell death; autophagy; cancer; metabolic disease; neurodegenerative disease
(This special issue belongs to the Section Molecular Biology)
Biomaterials and Antibacterial Materials for Bone Biology
edited by
submission deadline 15 Oct 2023 | Viewed by 302 | Submission Open
Keywords: biomaterials; antimicrobial activities; osteointegration; regenerative medicine; Gram-positive and Gram-negative bacteria
(This special issue belongs to the Section Materials Science)
Multi-Omics in Brain Health and Disease
edited by
submission deadline 15 Oct 2023 | Viewed by 224 | Submission Open
Keywords: omics; data integration; spatial multi-omics; neural circuit analysis; neurodegenerative disease; brain development  
(This special issue belongs to the Section Molecular Informatics)
Chronic Hypoxia and Inflammation in Human Pathology submission deadline 15 Oct 2023 | Viewed by 130 | Submission Open
Keywords: molecular aspects of hypoxia and inflammation in cancer; cancer progression as an integrated response to hypoxia adaptation and inflammation; hypoxia and inflammation in cardiology; hypertrophy; myocarditis; and heart failure; hypoxia and inflammation in storage diseases (such as Fabry's disease); hypoxia and inflammation in infiltrative diseases (amyloidosis and other beta-fibrillosis); hypoxia and inflammation in obesity and type 2 diabetes complications; hypoxia and inflammation in chronic inflammatory disease with progressive fibrosis; HIF/NFkB in neurodegenerative diseases; HIF/NFkB activation in other chronic hypoxic conditions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Towards Personalized Treatment and Molecular Research on Colorectal Cancer submission deadline 15 Oct 2023 | Viewed by 111 | Submission Open
Keywords: adenoma-carcinoma sequence; predictive biomarkers of response and toxicity in the adjuvant and metastatic settings; genetic and epigenetic marker; immunotherapy; prognostic biomarkers; angiogenesis; EGFR pathways; tumor biopsies; circulating tumor cells; tumor heterogeneity; early diagnosis; screening; liquid biopsy; molecular pathology; tumor biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Roles of VIP and PACAP: From Molecular and Genetic Studies 2.0
edited by
submission deadline 15 Oct 2023 | Viewed by 78 | Submission Open
Keywords: VIP; PACAP; stroke; Alzheimer’ s disease; cancer; dry syndrome  
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Insights into Glioblastoma: Cellular and Molecular
edited by
submission deadline 20 Oct 2023 | 8 articles | Viewed by 12091 | Submission Open
Keywords: glioblastoma; glioma; brain tumors; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products in Obesity: Novel Strategies and Molecular Mechanisms
edited by
submission deadline 20 Oct 2023 | 6 articles | Viewed by 8549 | Submission Open
Keywords: obesity; inflammation; white adipose tissue; adipogenesis; oxidative stress; metabolic disease; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances and Challenges in Dental Materials
edited by
submission deadline 20 Oct 2023 | 5 articles | Viewed by 8252 | Submission Open
Keywords: dental materials; material science; material interaction; biomaterials
(This special issue belongs to the Section Materials Science)
Pesticides Exposure and Toxicity
edited by
submission deadline 20 Oct 2023 | 8 articles | Viewed by 7743 | Submission Open
Keywords: multiple pesticides; cumulative assessment; probabilistic assessment; mechanisms of molecular toxicology
(This special issue belongs to the Section Molecular Toxicology)
Recent Advances in Drug Discovery submission deadline 20 Oct 2023 | 5 articles | Viewed by 6215 | Submission Open
Keywords: medicinal chemistry; inflammation; cancer; pain; drug design and discovery; chronic inflammatory diseases; neglected diseases; drug screening
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Compounds and Oxidative Stress
edited by
submission deadline 20 Oct 2023 | 6 articles | Viewed by 5497 | Submission Open
Keywords: oxidative stress; natural compounds; bioactive compounds; chronic diseases; therapeutic agents
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Hemostasis, Thrombosis, and Immunothrombosis
edited by and
submission deadline 20 Oct 2023 | 4 articles | Viewed by 5387 | Submission Open
Keywords: platelets; thrombosis; hemostasis; immunothrombosis; SARS-CoV-2; endothelium; leukocytes cardiovascular disease
(This special issue belongs to the Section Molecular Biology)
Biomaterials: From Design, Synthesis and Characterization to Application
edited by and
submission deadline 20 Oct 2023 | 5 articles | Viewed by 5319 | Submission Open
Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis
(This special issue belongs to the Section Materials Science)
Cardiovascular Diseases: Molecular Mechanisms and Potential Therapy
edited by
submission deadline 20 Oct 2023 | 8 articles | Viewed by 5224 | Submission Open
Keywords: cardiovascular diseases; pathogenic mechanisms; genetics; cardiomyopathy; myocardial infarction; cardiac fibrosis; pharmacogenomics; drug discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Amino Acid Metabolism and Disease 2.0
edited by
submission deadline 20 Oct 2023 | 4 articles | Viewed by 4860 | Submission Open
Keywords: amino acid transport; essential amino acids; hearing loss; liver disease; mutations; neurological disorders; oligomerization state; post-translational modifications; protein– protein interactions; structure/function relationships; sulfur amino acids
(This special issue belongs to the Section Biochemistry)
Potentialities and Challenges of Bio-Inspired Delivery Systems submission deadline 20 Oct 2023 | 4 articles | Viewed by 4771 | Submission Open
Keywords: drug delivery; nanomedicine; biomimetic delivery; biological carriers
(This special issue belongs to the Section Materials Science)
Novel Approaches to Potential COVID-19 Molecular Therapeutics
edited by , , Ivan Gentile and
submission deadline 20 Oct 2023 | 3 articles | Viewed by 2657 | Submission Open
Keywords: COVID-19; vaccines; therapeutics; antivirals; monoclonal antibodies; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Cell Mechanics
edited by
submission deadline 20 Oct 2023 | 1 articles | Viewed by 2298 | Submission Open
Keywords: cytomechanics; cell membrane; cancer cells; elasticity; stiffness; young modulus; cytoskeleton; endothelial cells; erythrocytes
(This special issue belongs to the Section Molecular Biophysics)
New Insight into Signaling and Autophagy in Plants 3.0 submission deadline 20 Oct 2023 | 2 articles | Viewed by 1904 | Submission Open
Keywords: autophagy cargo receptors; autophagy in plant development; autophagy in plant stress; crosstalk between autophagy and phytohormones; plant cell homeostasis; nutrients recycling; plant cell biology; plant signal transduction; selective autophagy; signaling molecules
(This special issue belongs to the Section Molecular Plant Sciences)
New Therapeutic Strategies for Lung Cancer: An Update
edited by
submission deadline 20 Oct 2023 | 1 articles | Viewed by 1629 | Submission Open
Keywords: lung cancer; lung metastasis; epithelial– mesenchymal transition (EMT); lung cancer therapeutics; mouse models of lung cancer; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Pathogenesis and Treatments of Head and Neck Cancer
edited by
submission deadline 20 Oct 2023 | Viewed by 1327 | Submission Open
Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology
(This special issue belongs to the Section Molecular Oncology)
Roles of KCTD Proteins in Biological Processes and Diseases: State of the Art and Future Perspectives
edited by
submission deadline 20 Oct 2023 | 1 articles | Viewed by 535 | Submission Open
(This special issue belongs to the Section Molecular Biology)
Animal Experimental Models in Bone Metabolic Disease 2.0
edited by Jose Luis Pérez-Castrillón and
submission deadline 20 Oct 2023 | Viewed by 259 | Submission Open
Keywords: animal experimental models; therapeutic targets; pathophysiology; bone metabolic disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Role of Vitamin C in Human Health and Diseases submission deadline 20 Oct 2023 | Viewed by 214 | Submission Open
Keywords: vitamin C; vitamin C deficiency; vitamin C supplementation; recommended dose; immune system; health; disease; inflammation; cell metabolism; oxidative stress; pharmacokinetics; immunity
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Novel Molecular and Cellular Biology Approaches in the Assessment of Radiation Effects
edited by
submission deadline 20 Oct 2023 | Viewed by 192 | Submission Open
Keywords: ionizing radiation; cytoplasmic targets of radiation; radiation induced bystander effects; extracellular vesicles; dna damage and repair; biomarkers; miRNA; proteomics; liquid biopsy; radiation carcinogenesis; radiation fibrosis
(This special issue belongs to the Section Molecular Biology)
Proteomics and Nanotechnology for Medical and Pharmacological Applications
edited by
submission deadline 20 Oct 2023 | Viewed by 177 | Submission Open
Keywords: biomolecules; peptides; proteomics; transcriptomics; nanotechnology; venomics
(This special issue belongs to the Section Molecular Pharmacology)
New Advances in Glycobiotechnology
edited by
submission deadline 20 Oct 2023 | Viewed by 167 | Submission Open
(This special issue belongs to the Section Biochemistry)
Oxidative Stress, Ferroptosis and Cancer
edited by
submission deadline 20 Oct 2023 | Viewed by 166 | Submission Open
Keywords: oxidative stress; ferroptosis; cancer; frailty
(This special issue belongs to the Section Molecular Biology)
Cellular Plasticity, Epithelial-Mesenchymal Transition and Metastasis
edited by
submission deadline 20 Oct 2023 | Viewed by 166 | Submission Open
Keywords: epithelial– mesenchymal transition (EMT); partial vs. full EMT; cellular plasticity; EMT in physiology and development; cancer; fibrosis; invasion and metastasis
(This special issue belongs to the Section Molecular Biology)
Molecular Research Progress of Familial Mediterranean Fever
edited by Gernot Kriegshäuser
submission deadline 20 Oct 2023 | Viewed by 136 | Submission Open
Keywords: Familial Mediterranean fever; pyrin; inflammasome; genotype-phenotype correlation; genetic epidemiology; disease modifying factor  
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Therapy in Autoimmune Disease
edited by
submission deadline 20 Oct 2023 | Viewed by 98 | Submission Open
Keywords: autoimmunity; autoimmune disease; cellular biology; molecular biology; cellular pathways; self-tolerance; molecular mechanisms; pathogenesis; therapy; personalized molecular medicine
(This special issue belongs to the Section Molecular Biology)
Penile Carcinoma and Other Male Genitourinary Tumors: Molecular and Cellular Mechanism
edited by
submission deadline 22 Oct 2023 | Viewed by 192 | Submission Open
Keywords: penile carcinoma; tumor biology; immune modulator; HPV  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Trends in Diabetes, Hypertension and Cardiovascular Diseases submission deadline 25 Oct 2023 | 13 articles | Viewed by 14510 | Submission Open
Keywords: cardiovascular disease; myocardial infarction; stroke; transient ischaemic attack; hypertension; diabetes mellitus; atherosclerosis; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances of Novel Pharmaceutical Designs for Anti-cancer Therapies 2.0
edited by
submission deadline 25 Oct 2023 | 6 articles | Viewed by 6518 | Submission Open
Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance
(This special issue belongs to the Section Molecular Pharmacology)
Small Molecule Drug Design and Research 2.0
edited by
submission deadline 25 Oct 2023 | 7 articles | Viewed by 5627 | Submission Open
Keywords: drug design; diversity-oriented synthesis; combinatorial chemistry; computationally guided synthesis; drug-like compounds; computer modeling techniques
(This special issue belongs to the Section Biochemistry)
Molecular Mechanism of Ovarian Cancer Initiation and Progression submission deadline 25 Oct 2023 | 2 articles | Viewed by 2235 | Submission Open
Keywords: early molecular events; ovarian carcinogenesis; initiation and progression; fallopian tube; HGSOC; genetic mutation; early detection; BRCA1/BRCA2; targeting of OC progression; animal model for OC initiation; microarray in OC; genetic/molecular disorders; angiogenesis; cell cycle progression in OC
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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