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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Rational Design and Synthesis of Bioactive Molecules submission deadline 25 Apr 2024 | 7 articles | Viewed by 6337 | Submission Open
Keywords: synthesis; structure; bonding; reactivity; chemical properties; physical properties; pharmacological activity; structure-activity relationship; applications
(This special issue belongs to the Section Molecular Pharmacology)
Noncovalent Interactions: New Developments in Experiment and Theory submission deadline 25 Apr 2024 | 7 articles | Viewed by 6273 | Submission Open
Keywords: noncovalent interactions; computational chemistry; hydrogen bonding; halogen bonding; spectroscopy
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Discovery of Gene Functions in Crops by Genome Editing and Genomics
edited by Dénes Dudits
submission deadline 25 Apr 2024 | 5 articles | Viewed by 5290 | Submission Open
Keywords: CRISPR vectors; transgenic; recombination; chromatin structure; directed mutagenesis for stress tolerance; oligonucleotide mutagenesis; in planta
(This special issue belongs to the Section Molecular Plant Sciences)
Structural Dynamics of Macromolecules
edited by
submission deadline 25 Apr 2024 | 3 articles | Viewed by 5179 | Submission Open
Keywords: Structural biology; Structural dynamics; Serial crystallography; X-ray crystallography; Cryo-EM time-resolved studies; Molecular dynamics
(This special issue belongs to the Section Molecular Biophysics)
Molecular Pathogenesis of Oral Potentially Malignant Disorders Transformation submission deadline 25 Apr 2024 | 3 articles | Viewed by 3843 | Submission Open
Keywords: oral potentially malignant disorders; oral cancer; molecular pathogenesis; oral leukoplakia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chlamydia trachomatis Pathogenicity and Disease 2.0
edited by
submission deadline 25 Apr 2024 | 2 articles | Viewed by 2403 | Submission Open
Keywords: Chlamydia trachomatis; virulence factors; host susceptibility or resistance; innate and adaptive; immune responses; genetic studies; cervico-vaginal microbiota; clinical outcomes with molecular study
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Quantum and Classical Molecular Dynamics
edited by
submission deadline 25 Apr 2024 | 2 articles | Viewed by 2204 | Submission Open
Keywords: quantum/classical dynamics; astrochemistry; photoinduced; non-adiabatic; ultrafast; ground/excited states chemistry; surface-hopping; QM/MM; photochemistry; direct dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advances in Plant Virus Diseases and Virus-Induced Resistance
edited by and Muqing Zhang
submission deadline 25 Apr 2024 | 2 articles | Viewed by 2123 | Submission Open
Keywords: virus detection; virus characterization; virus resistance; gene silencing; epigenetic regulation
(This special issue belongs to the Section Molecular Plant Sciences)
COVID-19 Pandemic: Therapeutic Strategies and Vaccines 2.0 submission deadline 25 Apr 2024 | 1 articles | Viewed by 1907 | Submission Open
Keywords: COVID-19; vaccines; virus
(This special issue belongs to the Section Molecular Microbiology)
Advances in Molecular Research of Strategic Crops submission deadline 25 Apr 2024 | 1 articles | Viewed by 1515 | Submission Open
Keywords: abiotic and biotic stresses; computational biology; data-driven approaches; functional genomics; genomic prediction; genome-wide association study; marker-assisted selection; molecular-based crop breeding; omics-based crop development; gene editing; strategic crops
(This special issue belongs to the Section Molecular Plant Sciences)
Bacterial Adaptation Strategies to the Host: From Acute, Aggressive to Chronic, Dormant Infections 2.0 submission deadline 25 Apr 2024 | 1 articles | Viewed by 1091 | Submission Open
Keywords: dormancy; phenotype switching; bacterial stress; survival strategies; persisters; resuscitation; starvation; cell cycle arrest; ATP homeostasis
(This special issue belongs to the Section Molecular Microbiology)
Genome Functions and Chromatin Organization in Health and Disease submission deadline 25 Apr 2024 | 1 articles | Viewed by 1055 | Submission Open
Keywords: genome organization; chromatin; chromosome rearrangements; chromosome repositioning; genetic diseases; epigenetic alterations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neuronal Inclusions in Neurodegeneration
edited by
submission deadline 25 Apr 2024 | 1 articles | Viewed by 1040 | Submission Open
(This special issue belongs to the Section Molecular Neurobiology)
Cancer Cell Metabolism: New Advances and Potential Therapies submission deadline 25 Apr 2024 | 1 articles | Viewed by 1001 | Submission Open
Keywords: Warburg effect; reprogrammed metabolism in cancer; metabolic targets; combined anticancer therapy; metabolic modulator drugs
(This special issue belongs to the Section Molecular Oncology)
The Power of GRAS Natural Compounds in Nanomedicine and Health submission deadline 25 Apr 2024 | Viewed by 469 | Submission Open
Keywords: advanced therapies; cancer; flavonoids; HPLC; metabolomics; nanomedicine; nanoparticles; natural compounds; oxidative stress; phenolic acids; ROS
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Glycosaminoglycans 2.0 submission deadline 25 Apr 2024 | Viewed by 403 | Submission Open
Keywords: biosynthesis of glycosaminoglycans; hyaluronan; chondroitin sulfate; heparin; modified GAGS; GAG bioactivity; GAGs as biomarkers; novel characterization methods; GAGs as drug or drug carriers; GAG= interaction with cells; in vitro cell-based assays; innovative biofabrication methodology based on GAGs; 3D scaffolds based on GAGs
(This special issue belongs to the Section Macromolecules)
The Role of Micronutrients in Metabolic and Infectious Diseases submission deadline 25 Apr 2024 | Viewed by 234 | Submission Open
Keywords: micronutrients; metabolic diseases; infectious diseases; cell culture
(This special issue belongs to the Section Molecular Biology)
Seed Reserve Mobilization: Unveiling Cellular and Molecular Mechanisms submission deadline 25 Apr 2024 | Viewed by 221 | Submission Open
Keywords: seed germination; reserve mobilization; vesicle trafficking; protein storage vacuoles (PSVs); oleosomes; seed storage tissues (endosperm; perisperm; cotyledon)
(This special issue belongs to the Section Molecular Plant Sciences)
New Advances in Protein Structure, Function and Design
edited by
submission deadline 25 Apr 2024 | Viewed by 177 | Submission Open
Keywords: AI applications in molecular structure; molecular simulations; new bioinformatics tools; protein structure; protein function; protein– protein interaction; online resources
(This special issue belongs to the Section Molecular Informatics)
Molecular Research of Nanocomposites: Design, Properties and Application
edited by
submission deadline 25 Apr 2024 | Viewed by 105 | Submission Open
Keywords: interfacial thermal resistance; polymer-based nanocomposites; polymers; thermal conductivity; thermal-interface materials
(This special issue belongs to the Section Materials Science)
Molecular Regulatory Mechanisms of Salinity Tolerance in Plants 2.0
edited by and
submission deadline 26 Apr 2024 | 4 articles | Viewed by 4064 | Submission Open
Keywords: salinity tolerance; ion transport; signal transduction; cell wall integrity; crops; trees; omics; redox regulation; post-translational modification
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Studies on Plant and Plant In Vitro Systems Secondary Metabolism
edited by
submission deadline 26 Apr 2024 | 1 articles | Viewed by 619 | Submission Open
Keywords: plants; plant in vitro systems; secondary metabolism; sustainable production; elicitation; metabolic engineering; CRISPR/Cas; molecular targets  
(This special issue belongs to the Section Molecular Plant Sciences)
Advancements in Understanding Protein Misfolding Disorders and Cancer
edited by
submission deadline 26 Apr 2024 | Viewed by 148 | Submission Open
Keywords: protein misfolding; cancer; amyloidosis
(This special issue belongs to the Section Molecular Oncology)
Flagella 2.0 submission deadline 27 Apr 2024 | 6 articles | Viewed by 6787 | Submission Open
Keywords: flagellar structure; flagellar assembly; flagellar gene regulation; chemotaxis; motility; vaccine adjuvant; flagellotropic bacteriophage
(This special issue belongs to the Section Molecular Microbiology)
The Role of Bioactive Compounds in Cancer, Inflammation and Other Diseases
edited by
submission deadline 27 Apr 2024 | 5 articles | Viewed by 4165 | Submission Open
Keywords: cancer; inflammation; cardiovascular diseases; plants; bioactive compounds
(This special issue belongs to the Section Molecular Pharmacology)
Oxidative Stress and Antioxidants in Human Diseases
edited by Lyubov Iljinichna Kolesnikova
submission deadline 28 Apr 2024 | 12 articles | Viewed by 16844 | Submission Open
Keywords: oxidative stress; metabolic stress; diseases; aging; antioxidants; free radical pathology; reactive oxygen species; cellular damage; antioxidant therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Molecular Mechanisms of Liver Fibrosis
edited by Tilman Sauerbruch and
submission deadline 28 Apr 2024 | 6 articles | Viewed by 8618 | Submission Open
Keywords: fibrosis; hepatic stellate cells; portal hypertension; extracellular matrix; cytokines; chemokines; biomarkers; NASH; NAFLD; cirrhosis; hepatocellular carcinoma; therapy; animal models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Breast Cancer: Toward Advanced Therapy
edited by and Sasagu Kurozumi
submission deadline 28 Apr 2024 | 7 articles | Viewed by 8388 | Submission Open
Keywords: molecular tumor biology; tumor immunology; tumor microenvironment; premetastatic niche; cancer biomarkers; microRNAs; exosomes; cancer therapy; cancer epidemiology and prevention; metastasis inhibition; cancer stem cell
(This special issue belongs to the Section Molecular Oncology)
Antiviral Drug Targets: Structure, Function, and Drug Design 2.0
edited by and
submission deadline 28 Apr 2024 | 4 articles | Viewed by 4899 | Submission Open
Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs
(This special issue belongs to the Section Molecular Pharmacology)
Update on Immunotherapies for Cancer submission deadline 28 Apr 2024 | 2 articles | Viewed by 3712 | Submission Open
Keywords: cell therapies; monoclonal antibodies; molecular adjuvants; oncolytic therapies; immunogenic; chemotherapy and radiotherapy; cancer vaccines; immunodominance; neoantigens; clinical trials; tumor immune microenvironment
(This special issue belongs to the Section Molecular Oncology)
Obesity and Insulin Resistance: The Dark Sides of Adipose Organ Dysfunction in the Cardiometabolic Continuum submission deadline 28 Apr 2024 | 2 articles | Viewed by 2355 | Submission Open
Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; adipose precursor cell; endothelial dysfunction; brown adipose tissue; fatty liver; lipokines; oxidative stress; senescence
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Estrogen Receptors in Health and Diseases submission deadline 28 Apr 2024 | 1 articles | Viewed by 1861 | Submission Open
Keywords: estrogen receptors; physiology; pathobiology; cancer; benign diseases and disorders  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immune-Inflammatory and Oxidative Stress Signaling Pathways Involved in Human Disorders submission deadline 28 Apr 2024 | 2 articles | Viewed by 1661 | Submission Open
Keywords: inflammation; neuroinflammation; immune system; oxidative stress
(This special issue belongs to the Section Molecular Immunology)
Protein Biosensors submission deadline 28 Apr 2024 | 1 articles | Viewed by 1422 | Submission Open
(This special issue belongs to the Section Biochemistry)
Molecular Perspective of Cardiovascular Diseases
edited by
submission deadline 28 Apr 2024 | 1 articles | Viewed by 1092 | Submission Open
Keywords: cardiovascular diseases; cardiology; inflammation; atherosclerosis; cardiomyopathy; endothelial cell
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Evolving Ribosome Concept
edited by
submission deadline 28 Apr 2024 | 1 articles | Viewed by 718 | Submission Open
Keywords: specialised ribosomes; ribosome heterogeneity; differential rRNA modification; ribosomal protein paralog genes; variation ribosome composition
(This special issue belongs to the Section Molecular Genetics and Genomics)
Signal Transduction and Relevant Drugs
edited by
submission deadline 28 Apr 2024 | Viewed by 263 | Submission Open
Keywords: 3D cell cultures; multi-organ microfluidics; iPSC; organoids; metabolomics; mitochondria; signaling
(This special issue belongs to the Section Molecular Pharmacology)
Cardiac Arrhythmia: Molecular Mechanisms and Therapeutic Strategies submission deadline 29 Apr 2024 | 6 articles | Viewed by 7703 | Submission Open
Keywords: ion channel; atrial fibrillation; cardiac sudden death; after-depolarization; mathematical model analysis; catheter ablation; antiarrhythmic drug; medical device
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Plants and Insects Interactions
edited by and Xiaoling Sun
submission deadline 29 Apr 2024 | 6 articles | Viewed by 6731 | Submission Open
Keywords: plant defense responses; elicitors; effectors; defense-related signaling; insect– plant interactions; tritrophic interactions; detoxification; defensive compounds; defensive genes
(This special issue belongs to the Section Molecular Plant Sciences)
Calcium Signaling in Health and Diseases submission deadline 29 Apr 2024 | 2 articles | Viewed by 3607 | Submission Open
Keywords: store-operated calcium entry in health and disease; mitochondrial calcium in health and disease; subcellular calcium homeostasis; calcium signaling in cancer; calcium signaling in aging and neurodegenerative disorders; calcium signaling in inflammation and immune response
(This special issue belongs to the Section Molecular Biology)
Advances in Molecular Breeding for Pest and Disease Resistance in Legume Crops submission deadline 29 Apr 2024 | 2 articles | Viewed by 2732 | Submission Open
Keywords: legume crops; genetic resistance; molecular breeding; diseases; plant– pathogen interaction; genomic selection; marker-assisted breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Autophagy and Immunoregulation in Human Diseases submission deadline 29 Apr 2024 | 1 articles | Viewed by 1448 | Submission Open
Keywords: autophagy; immunoregulation; pathogens; host immune response; immune evasion; signaling; non-coding RNAs; lipid mediators; cytokines; host defense
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Polygenic Risk Scores for Complex Traits in the Genome-Wide Association Study (GWAS) Era
edited by
submission deadline 29 Apr 2024 | 1 articles | Viewed by 806 | Submission Open
Keywords: precision medicine; genetic; gene– gene; gene– environment
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Molecular Dynamics Simulation of Chemical and Biomedical Systems submission deadline 29 Apr 2024 | 1 articles | Viewed by 503 | Submission Open
Keywords: molecular dynamics simulation; chemical and biomedical systems; molecular-level processes; protein structures; drug binding mechanisms; biomolecular behavior; drug design; biomedicine materials
(This special issue belongs to the Section Molecular Informatics)
Synthesis and Applications of Photoactive Molecules and Photovoltaic Materials submission deadline 29 Apr 2024 | Viewed by 256 | Submission Open
Keywords: photochemistry; chromophores; light-activated systems; donor– acceptor structures; covalent and noncovalent chemistry; solar cells
(This special issue belongs to the Section Materials Science)
The Human Fetal Membranes: A Versatile Tissue Important for Pregnancy Health and Regenerative Therapies
edited by Claire E. Kendal-Wright and Lauren Richardson
submission deadline 29 Apr 2024 | Viewed by 250 | Submission Open
Keywords: fetal membranes; tissue strength; inflammation; parturition; preterm premmature rupture of the membrane (PPROM); infection; stem cells; regenerative surgery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Physiological Benefits of Dietary Selenium
edited by and Hugh Harris
submission deadline 29 Apr 2024 | Viewed by 223 | Submission Open
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in Materials for Emerging Solar Cells
edited by and Francesco Pattini
submission deadline 29 Apr 2024 | Viewed by 218 | Submission Open
Keywords: photovoltaics; materials; solar cells; perovskite; thin film; efficiency; electrical characterization; absorber; transparent conductive oxide; charge transport layer
(This special issue belongs to the Section Materials Science)
The Role of Metals in Biomedicine: Diagnosis and Therapy
edited by
submission deadline 29 Apr 2024 | Viewed by 204 | Submission Open
Keywords: synthesis of basic metal compounds and bioactives metal nano-objects; biomedical applications; metal-based biosensors; biocatalysis delivers; metal-based drugs; nanomedicine; metal toxicity
(This special issue belongs to the Section Biochemistry)
New Aspects of Bioenergetics in Cancer
edited by
submission deadline 29 Apr 2024 | Viewed by 192 | Submission Open
Keywords: cancer metabolism; bioenergetics; mitochondria; redox
(This special issue belongs to the Section Molecular Oncology)
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