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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Stem Cell Applications and Innovations in Developmental and Degenerative Disorders submission deadline 31 Jul 2024 | Viewed by 33 | Submission Open
Keywords: stem cell; degenerative disorders; neurodevelopmental disorders
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Biology of Senescence and Anti-aging Strategies
edited by
submission deadline 31 Jul 2024 | Viewed by 32 | Submission Open
Keywords: cellular senescence; aging; delaying senescence; aging-associated diseases
(This special issue belongs to the Section Molecular Biology)
Chronic Pain: Diagnosis, Pathophysiological Mechanisms and Treatment
edited by and Thomas Herdegen
submission deadline 31 Jul 2024 | Viewed by 32 | Submission Open
Keywords: chronic pain; sex differences; age differences; pain therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Opportunities and Challenges in the Use of Live Biotherapeutics to Fight Infections in the Era of Multi-Drug-Resistance
edited by
submission deadline 31 Jul 2024 | Viewed by 32 | Submission Open
Keywords: probiotics; postbiotics; bioengineered probiotics; engineered bacterium; next-generation probiotics; phage; phage therapy; multi-drug-resistant organisms; microbiota replacement; live biotherapeutic product
(This special issue belongs to the Section Molecular Immunology)
Aptamer-Based Tissue-Targeted Drug Delivery
edited by Zongkang Zhang
submission deadline 31 Jul 2024 | Viewed by 31 | Submission Open
Keywords: drug delivery system; nucleic acid aptamer; drug targeting; drug carrier; tumor targeting; off-target effect; nanomedicine; SELEX
(This special issue belongs to the Section Molecular Pharmacology)
Protein Unfolding Induced by Chemical Agents
edited by and
submission deadline 31 Jul 2024 | Viewed by 31 | Submission Open
Keywords: protein stability; chemical unfolding; denaturing conditions; protein folding; folding pathway; misfolding; conformational flexibility; disordered state; protein aggregation; protein drugs
(This special issue belongs to the Section Biochemistry)
Recent Advances in Protein-Graphene Supramolecular Assemblies
edited by
submission deadline 31 Jul 2024 | Viewed by 30 | Submission Open
Keywords: protein supramolecular assemblies; protein-2D materials nanostructures  ; tailored molecular interactions; sequencing; sensing; detection
(This special issue belongs to the Section Biochemistry)
Research of Mitochondrial Function, Structure, Dynamics and Intracellular Organization: 3nd Edition submission deadline 31 Jul 2024 | Viewed by 30 | Submission Open
Keywords: confocal fluorescent imaging; mitochondria; energy metabolism; mitochondrial function; mitochondrial dynamics; mitochondrial intracellular organization; heterogeneity; metabolic diseases; reactive oxygen species; signaling
(This special issue belongs to the Section Molecular Biology)
Molecular Pathogenesis and Therapeutics in Retinopathy
edited by Fabiana Picconi
submission deadline 31 Jul 2024 | Viewed by 30 | Submission Open
Keywords: retinal neurodegeneration; retinal neurovascular unit; diabetic retinopathy; diabetic neuropathy; diabetic milieu; glucose variability
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Hypoxia, Normoxia and Hyperoxia in Cancer Initiation and Propagation
edited by Mary M. Salvatore
submission deadline 31 Jul 2024 | Viewed by 29 | Submission Open
Keywords: hypoxia; normoxia; hyperoxia; cancer initiation; cancer propagation
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanism of Pollen and Pollen Tube Development
edited by Yujin Kim
submission deadline 31 Jul 2024 | Viewed by 29 | Submission Open
Keywords: plant physiology; pollen tube growth; reproductive development
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Periodontitis Diagnosis and Treatment
edited by
submission deadline 31 Jul 2024 | Viewed by 29 | Submission Open
Keywords: periodontitis; peri-implantitis; point-of-care diagnostic; molecular diagnostic; metalloproteinase 8; biomarkers; host-modulation medication; plaque control
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Pathophysiology and Treatment of Diabetic Retinopathy
edited by Federico Gonzalez-Fernandez and
submission deadline 31 Jul 2024 | Viewed by 29 | Submission Open
Keywords: diabetic retinopathy; age-related macular degenerations; retinal; vascular endothelial growth factor; visual system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurodevelopment and Novel Embryology-Based Regeneration Strategies submission deadline 31 Jul 2024 | Viewed by 28 | Submission Open
Keywords: neurodevelopment; regeneration strategies; embryology; nervous system repair; neural tissue engineering; induced pluripotent stem cells; neurological disorders; tissue regeneration; neural growth cues; regenerative medicine; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Autoimmune Diseases submission deadline 31 Jul 2024 | Viewed by 28 | Submission Open
Keywords: autoimmune diseases; autoantibodies; biomarkers; immuno-inflammatory diseases; molecular pathways; translational research; molecular pathobiology; targeted therapy
(This special issue belongs to the Section Molecular Immunology)
Ischemia Reperfusion Injury: A Cell Signaling Crossroads and Therapeutics 2.0
edited by , and Arnau Panisello-Roselló
submission deadline 31 Jul 2024 | Viewed by 27 | Submission Open
Keywords: ischemia– reperfusion injury; transplantation; liver; pancreas; small intestine; HOPE; glycocalyx; inflammation; oxidative and endoplasmic reticulum stress; pharmacological treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Neurodegeneration and Neuroprotection for Retinal and Optic Nerve Diseases
edited by
submission deadline 31 Jul 2024 | Viewed by 27 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Hair Regeneration
edited by
submission deadline 31 Jul 2024 | Viewed by 27 | Submission Open
Keywords: hair loss; androgenic alopecia; alopecia areata; cell therapy; antibody therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Natural Compound for Wound and Tissue Repair and Regeneration 3.0 submission deadline 31 Jul 2024 | Viewed by 26 | Submission Open
Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular-Level Research Progress of Film Coating submission deadline 31 Jul 2024 | Viewed by 26 | Submission Open
Keywords: coatings; thin films; biocompatible materials; drug coatings; biodegradable materials; molecular research
(This special issue belongs to the Section Materials Science)
Molecular and Genetic Studies on Tourette Syndrome and Comorbid Disorders
edited by Jakub P. Fichna
submission deadline 31 Jul 2024 | Viewed by 26 | Submission Open
Keywords: Tourette syndrome; genetics and genomics; molecular neurobiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Interactions of Nanoparticles with Biomolecules II submission deadline 31 Jul 2024 | Viewed by 25 | Submission Open
Keywords: bioactive molecules; nanoparticles; functionalization; encapsulation; biomolecule delivery systems; nanoparticle therapy; nanoparticle diagnosis
(This special issue belongs to the Section Molecular Nanoscience)
Advances and Challenges of Molecular Research on Disease in Animal Models in Biomedicine
edited by Minolfa C. Prieto
submission deadline 31 Jul 2024 | Viewed by 25 | Submission Open
Keywords: animal models; cardiovascular disease; renal disease; metabolic; neurological; behavioral; and oncological disorders; pathophysiology; cell and molecular research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Cell Biology of Pancreatic Diseases
edited by Hirohito Ichii
submission deadline 31 Jul 2024 | Viewed by 24 | Submission Open
Keywords: pancreatic diseases; pancreas; cell and molecular biology; pathogenesis; islet; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Omics Sciences for Salivary Diagnostics 2.0 submission deadline 31 Jul 2024 | Viewed by 22 | Submission Open
Keywords: saliva; proteomics; metabolomics; metaproteomics; microbiomics; transcriptomics; mass spectrometry; biomarkers; PTMs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Anticancer Drug Discovery Based on Natural Products
edited by Su-Yun Lyu
submission deadline 31 Jul 2024 | Viewed by 22 | Submission Open
Keywords: anticancer drug discovery; natural products; phytochemicals; traditional medicine; drug development; preclinical studies; clinical trials
(This special issue belongs to the Section Molecular Pharmacology)
Diverse Functional Roles of Fibrinogen and Fibrin in Mechanisms of Disease
edited by
submission deadline 31 Jul 2024 | Viewed by 21 | Submission Open
Keywords: fibrinogen; fibrin; endothelium; thrombosis; hemostasis; infection; cancer; inflammation
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Nanomedicines against Bacterial Infections
edited by , Nuno Guimarães, and
submission deadline 31 Jul 2024 | Viewed by 21 | Submission Open
Keywords: nanotechnology; nanoparticle; nanocarriers; nanoantibiotic; drug delivery system; targeted delivery; theranostic; infectious diseases; antibacterial agent; antimicrobial resistance; biomedical application
(This special issue belongs to the Section Molecular Nanoscience)
New Insights into Cancer Metabolism: Signaling Pathways and Therapeutic Targets submission deadline 31 Jul 2024 | Viewed by 21 | Submission Open
Keywords: cancer metabolism; signaling pathways; therapeutic targets; chemoresistance; microdomains
(This special issue belongs to the Section Molecular Oncology)
Editorial Board Members’ Collection Series: Human Traits and Genomics submission deadline 31 Jul 2024 | Viewed by 20 | Submission Open
Keywords: genetic data analysis; genomic profiling; trait inheritance; DNA and RNA sequencing approaches; deep learning methods
(This special issue belongs to the Section Molecular Genetics and Genomics)
Epigenetics in Autoimmune Diseases
edited by
submission deadline 31 Jul 2024 | Viewed by 20 | Submission Open
Keywords: autoimmune disease; DNA methylation; histone modifications; miRNAs; long non-coding RNAs; circRNAs; environmental effects; epigenome-wide analysis; DNMT inhibitors; HDAC inhibitors
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetic Research in Cardiac Diseases
edited by Maria Teresa De Angelis
submission deadline 31 Jul 2024 | Viewed by 20 | Submission Open
Keywords: heart development; heart diseases; animal models; patient-derived pluripotent stem cell-cardiomyocytes (PSC-CMs); genome editing; genetically induced diseased PSC-CMs; 3D cardiac disease models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis and Function of Mycolic Acids and the Mycomembrane
edited by
submission deadline 31 Jul 2024 | Viewed by 20 | Submission Open
Keywords: actinobacteria; Corynebacterium; host– pathogen interaction; Mycobacterium; mycolic acids; mycomembrane; Nocardia; phagolysosome maturation; Rhodococcus; trehalosyldimycolate  
(This special issue belongs to the Section Molecular Microbiology)
Food Derived Biomolecules in Reducing the Risk of Diseases
edited by
submission deadline 31 Jul 2024 | Viewed by 19 | Submission Open
Keywords: food derived biomolecules; chronic diseases; antioxidant; anti-inflammatory
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Editorial Board Members’ Collection Series: “Molecular Research in Dementia” submission deadline 31 Jul 2024 | Viewed by 19 | Submission Open
Keywords: dementia; amyloid beta; tau proteins; neuroinflammation; synaptic dysfunction; mitochondrial dysfunction
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Glia in Neuropsychiatric Disorders
edited by
submission deadline 31 Jul 2024 | Viewed by 19 | Submission Open
Keywords: glial cells; astrocytes; microglia; neuro-inflammation; synaptic plasticity; neuropsychiatric disorders
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research in Avian Genetics
edited by
submission deadline 31 Jul 2024 | Viewed by 18 | Submission Open
Keywords: avian genetics; cytogenetics and genomics in wild and domesticated birds; bioinformatic analysis; molecular markers; molecular studies in birds; molecular mechanisms underlying physiology and ecology of birds; molecular insights into evolution; conservation; reproduction; illness and commercial utilization; host– pathogen interaction
(This special issue belongs to the Section Molecular Genetics and Genomics)
Reproductive Endocrinology Research
edited by
submission deadline 31 Jul 2024 | Viewed by 18 | Submission Open
Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Insights into Colitis submission deadline 31 Jul 2024 | Viewed by 18 | Submission Open
Keywords: colitis; treatments; molecular mechanisms of colon inflammation; preclinical and clinical studies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Prevention and Treatment of Metabolic Diseases Using Natural Products
edited by
submission deadline 31 Jul 2024 | Viewed by 18 | Submission Open
Keywords: metabolic diseases; metabolic disorders; natural products; specific proteins; antioxidant ability
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Immune System and Immune Responses in Fish and Their Role in Comparative Immunity Study
edited by Qunlan Zhou
submission deadline 31 Jul 2024 | Viewed by 17 | Submission Open
Keywords: innate immunity; adaptive immunity; antioxidant capacity; inflammation; intestinal immunologic barrier; vaccine; gene editor
(This special issue belongs to the Section Molecular Immunology)
New Therapies for Acute Myeloid Leukemia
edited by Eduardo Anguita
submission deadline 31 Jul 2024 | Viewed by 14 | Submission Open
Keywords: acute myeloid leukemia; BCL2 inhibitors; leukemic cells; new therapies for AML; prognostic implications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Environmental Toxicology submission deadline 1 Aug 2024 | Viewed by 42 | Submission Open
Keywords: environmental toxicology; natural compounds; toxic pollutants; natural toxins; endocrine disruptors exposure
(This special issue belongs to the Section Molecular Toxicology)
Radiation-Induced DNA Damage, Repair and Responses
edited by
submission deadline 10 Aug 2024 | 1 articles | Viewed by 1268 | Submission Open
Keywords: MR; EM; and fish molecular imaging; influence of EU hetero-chromatin; radiation type influence; mutation and cancer incidence; therapeutic possibilities
(This special issue belongs to the Section Molecular Biophysics)
New Trends and Challenges in Polysaccharide Biomaterials
edited by Izabela Pawlaczyk-Graja and
submission deadline 10 Aug 2024 | Viewed by 229 | Submission Open
Keywords: polysaccharides; glucoconjugates; functional materials; hydrogels; nanoparticles and nanofibers; microparticles; cellulose derivatives; biocompatibility and biological functions; biomedical applications; tissue engineering; drug delivery; food chemistry
(This special issue belongs to the Section Biochemistry)
Cancer Immunotherapy: Tumor Microenvironment, Biomarker Discovery and Immune Resistance 2.0 submission deadline 10 Aug 2024 | Viewed by 184 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; biomarkers; immune resistance; T cells; immune checkpoint; tumor-infiltrating lymphocytes; tumor mutational burden; dendritic cells; PD-L1
(This special issue belongs to the Section Molecular Oncology)
Diabetes-Related Cognitive Impairment Diseases
edited by
submission deadline 10 Aug 2024 | Viewed by 51 | Submission Open
Keywords: Alzheimer’ s disease; amyloid-hyperglycemia; insulin resistance; mitochondrial dysfunction; cerebrovascular diseases; metabolic diseases; neuroinflammation; tau hyperphosphorylation; type 2 diabetes; vascular cognitive impairment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Cancer Molecular Imaging
edited by Mi-Ae Park
submission deadline 10 Aug 2024 | Viewed by 32 | Submission Open
Keywords: molecular imaging; radiology; cancer detection; precision medicine; cancer mechanisms
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Tumor Progression and New Therapeutic Strategies for Urological Cancers 2.0 submission deadline 15 Aug 2024 | 4 articles | Viewed by 2869 | Submission Open
Keywords: prostate cancer; bladder cancer; renal cell carcinoma; upper urinary tract tumors; testicular cancer; predictive and prognostic biomarkers; tumor progression; novel treatment strategies; chemotherapy; immunotherapy; target therapies; drug resistance mechanisms; tumor microenvironment; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Adaptations of Plant Metabolism and Their Consequences on Nutritive Potential and Bioactivity
edited by
submission deadline 15 Aug 2024 | 3 articles | Viewed by 2143 | Submission Open
Keywords: plant primary metabolism; plant specialized metabolism; phytochemistry; plant bioactive components; plant metabolic plasticity; plant nutritional value; bioactivity of plant extracts; plant– stress response; abiotic stress; climate change; global warming; environmental pressure; biotic stress; anthropogenic influence on plant metabolites; predictive models
(This special issue belongs to the Section Molecular Plant Sciences)
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