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Special Issue "A Molecular Perspective on Reproductive Health"

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Department of Animal Medicine and Surgery, Veterinary School, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
Interests: amniotic fluid; semen analysis; embryos; theriogenology; cryopreservation; reproductive biology; semen preservation
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Dear Colleagues,

I am very pleased to invite you to submit your contributions to this Special Issue of the International Journal of Molecular Science, which is focused on a molecular perspective of reproductive health. Reproduction, as with any other physiological function, is molecular based, and its comprehension will result in a better understanding of the mechanisms behind it. A better understanding of its molecular functioning may supply tools that could be useful in the diagnosis, treatment, and prognosis of reproductive pathologies, thus improving the clinical approach and, in turn, providing better solutions to the patients.

Dr. Maria Montserrat Rivera Del Álamo
Guest Editor

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Keywords

reproductive function
molecular bases
male
female
reproductive pathology
reproductive physiology

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Immune Checkpoints in Recurrent Pregnancy Loss: New Insights into a Detrimental and Elusive Disorder

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Int. J. Mol. Sci. 2023, 24(17), 13071; https://doi.org/10.3390/ijms241713071 - 22 Aug 2023

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Abstract

Recurrent pregnancy loss (RPL) refers to two or more miscarriages before 20 weeks gestation. Its prevalence is 1–2%; its pathogenesis remains unexplained in more than 50% of cases, in which the cause is thought to be abnormal immune activity during placentation leading to a lack of pregnancy-induced immune tolerance. It is unknown whether immune activity is deranged in the endometrium of women with RPL. We studied the gene expression and the quantitative tissue protein levels of three immune checkpoints (CD276, which enhances cytotoxic T-cell activity, cytotoxic T-lymphocyte-associated antigen-4 [CTL-4], which reduces Th1 cytokine production, and lymphocyte activation gene-3 [LAG-3], which shows suppressive activity on Tregs and CD4+ T-cells) in endometrial samples from 27 women with unexplained RPL and in 29 women with dysfunctional uterine bleeding and previous uneventful pregnancies as controls. RNA isolation, real-time PCR, protein isolation, and ELISA were performed. CD276 gene expression and protein tissue levels were significantly lower in the endometrium of the RPL group than in the controls, whereas both CTL-4 and LAG-3 were significantly higher. This difference suggests defective endometrial immune regulation and overactivation of immune response in women with a history of RPL, at least in relation to controls with dysfunctional uterine bleeding and previous normal reproductive history. Full article

(This article belongs to the Special Issue A Molecular Perspective on Reproductive Health)

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Special Issue "A Molecular Perspective on Reproductive Health"

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