Special Issue "Calpain Family in Health and Diseases: The Road Ahead"
Deadline for manuscript submissions: 15 March 2024 | Viewed by 674
Calpains, Ca2+-dependent intracellular proteases, are comprised of 15 homologues in mammals, and are classified into conventional and unconventional isozymes. Conventional isozymes are composed of calpain-1 and -2, which are ubiquitously expressed in almost all eukaryotes. Growing evidence suggests that these conventional isozymes proteolytically modify intracellular signalling molecules, thereby altering cellular processes including inflammatory cascades. Accordingly, defective calpain-mediated proteolysis may be involved in the pathogenesis of human diseases, such as cardiometabolic disease, neurodegenerative disorders, and cancer progression. In contrast to the conventional isozymes, unconventional calpains are expressed in a tissue-specific manner. Earlier investigations have identified pathogenic roles of unconventional calpains in a variety of diseases, including cancer and retinal degeneration, whereas targeting calpain-3 can induce limb girdle muscular dystrophy type 2A (LGMD2A). The current Special Issue highlights the recent advances in molecular-based analyses of conventional and unconventional calpains to elucidate the pathophysiological aspects of these molecules and possible clinical applications.
Dr. Takuro Miyazaki
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- chronic inflammation
- gene-targeted mice
- limited proteolytic cleavage
- protein catabolism
- cardiometabolic disease
- neurodegenerative disease