Molecular Research on Cardiac Troponin
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 May 2024 | Viewed by 2752
Special Issue Editor
Interests: cardiac troponins; troponin T and troponin I; myocardial damage; cardiac troponin metabolism; molecular mechanisms; molecular biology; mechanisms of release; transportation of cardiac troponins; mechanisms of elimination; expression of cardiac troponins; regulation of myocardial contraction; post-translational modifications; folding; phosphorylation; glycosylation; proteolysis; myocarditis; Takotsubo syndrome; heart failure; cardiac amyloidosis; acute myocardial infarction; cardiomyopathies; cardiac arrhythmias; pulmonary embolism; diagnostics; non-invasive diagnostics; chronic renal failure
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Special Issue Information
Dear Colleagues,
Cardiac troponins (troponin T and troponin I) are cardiospecific proteins and one of the key criteria for detecting damage to the myocardial cells, which is always characteristic of ischemic necrosis of the cardiac muscle (acute myocardial infarction) and is quite often registered in case of many non-ischemic cardiac diseases (myocarditis, Takotsubo syndrome, cardiac amyloidosis, cardiomyopathies, cardiac arrhythmias) and non-cardiac (pulmonary embolism, chronic renal failure, sepsis, chronic obstructive pulmonary disease, strokes, oncological diseases and treatment with cardiotoxic chemotherapeutic drugs (Doxorubicin, Trastuzumab, etc.) and a number of others) pathological conditions. However, the molecular mechanisms underlying the release of cardiac troponin molecules from the myocardial cells have not been established conclusively or are of contradictory nature. This circumstance significantly limits the use of cardiac troponins in clinical practice for diagnostics and monitoring of the pathological conditions that cause damage to the myocardial cells. Besides, recently many of our ideas of the diagnostic value of cardiac troponins have changed quite significantly. Thus, due to the increased sensitivity of the methods for determining troponins T and I (highly sensitive immunoassays), it was shown that a number of biological factors (gender, age, circadian rhythms, stressful situations, physical activity, etc.) can have a significant effect on the serum levels of cardiac troponins, and, consequently, on the diagnostic value. However, the molecular mechanisms underlying the influence of biological factors on the levels of cardiac troponins T and I have not been established yet, and the diagnostic role, according to a number of authors, is of contradictory nature. Recent studies have reported the ability to detect cardiac troponins T and I in urine, oral fluid, and sweat. Despite the many advantages of these biomaterials (non-invasive, fast, atraumatic and painless collection), the diagnostic value of cardiac troponins in these biological fluids is understudied and controversial. Besides, the molecular mechanisms of transportation of cardiac troponins into these biological fluids are unknown. The processes of post-translational modifications (folding, phosphorylation, glycosylation, proteolysis, etc.), which can have an effect on the pathogenesis of cardiac pathologies (myocardial infarction, cardiomyopathies, cardiac insufficiency, cardiac arrhythmias, etc.), form an important and little-studied problem in molecular biology of cardiac troponins. Progress in the field of molecular genetic research methods has made it possible to establish a large number of mutations in cardiac troponins T, I and C, which are associated with congenital cardiomyopathies. Understanding the molecular mechanisms underlying congenital cardiomyopathies and post-translational troponin modifications will open up new targets for therapeutic intervention and optimize patient management. This special issue is intended for review and original manuscripts devoted to the molecular biology of cardiac troponins.
Dr. Aleksey Chaulin
Guest Editor
Manuscript Submission Information
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Keywords
- cardiac troponins
- troponin T and troponin I
- myocardial damage
- cardiac troponin metabolism
- molecular mechanisms
- molecular biology
- mechanisms of release
- transportation of cardiac troponins
- mechanisms of elimination
- expression of cardiac troponins
- regulation of myocardial contraction
- post-translational modifications
- folding
- phosphorylation
- glycosylation
- proteolysis
- myocarditis
- Takotsubo syndrome
- heart failure
- cardiac amyloidosis
- acute myocardial infarction
- cardiomyopathies
- cardiac arrhythmias
- pulmonary embolism
- diagnostics
- non-invasive diagnostics
- chronic renal failure
