High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Study Design
4.2. Laboratory Analyses
4.3. Clinical Endpoints
4.4. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Total (n = 949) | Group 1 (0.09–0.1) (n = 316) | Group 2 (0.14–0.2) (n = 316) | Group 3 (0.34–1.12) (n = 317) | p-Value | |
---|---|---|---|---|---|
Age (years) | 67.5 ± 9.5 | 67.1 ± 9.5 | 68.0 ± 9.5 | 67.3 ± 9.5 | 0.07 |
Male Sex | 660 (69.5%) | 249 (78.8%) | 215 (68.0%) | 196 (61.8%) | <0.001 |
Hypertension | 682 (71.9%) | 235 (74.4%) | 231 (73.1%) | 216 (68.1%) | 0.18 |
Diabetes | 494 (52.1%) | 163 (51.6%) | 167 (52.8%) | 164 (51.7%) | 0.94 |
Dyslipidemia | 716 (75.4%) | 239 (75.6%) | 244 (77.2%) | 233 (73.5%) | 0.55 |
Previous MI | 486 (51.6%) | 138 (43.8%) | 161 (51.4%) | 187 (59.2%) | 0.004 |
Previous Angina | 199 (21%) | 51 (16.1%) | 72 (22.8%) | 76 (24.0%) | 0.03 |
Smoking | 503 (53.2%) | 165 (52.4%) | 164 (52.2%) | 174 (54.9%) | 0.75 |
Previous PCI | 383 (40.5%) | 134 (42.4%) | 136 (43.3%) | 113 (35.6%) | 0.16 |
Previous CABG | 332 (35.1%) | 115 (36.4%) | 116 (36.9%) | 101 (31.9%) | 0.34 |
Previous HF | 340 (35.9%) | 82 (25.9%) | 110 (34.9%) | 148 (46.7%) | <0.001 |
LVEF % | 55 (40–63) | 60 (51–65) | 55 (40–61.5) | 43 (35–60) | 0.49 |
CAD Single-Vessel Double-Vessel Triple-Vessel | 96 (10.6%) 286 (31.5%) 526 (57.9%) | 42 (13.7%) 102 (33.2%) 163 (53.1%) | 26 (8.7%) 87 (29.1%) 186 (62.2%) | 28 (9.3%) 97 (32.1%) 177 (58.6%) | 0.12 |
Creatinine (mg/dL) | 1.11 (0.95–1.30) | 1.06 (0.9–1.22) | 1.12 (0.94–1.31) | 1.17 (0.98–1.39) | 0.83 |
Total Cholesterol (mg/dL) | 153 (129–188) | 149 (126–185) | 156 (130–185) | 155 (133–192) | 0.68 |
LDL-Cholesterol (mg/dL) | 82 (64–109) | 77 (62–105) | 83 (65–108) | 86 (66–113) | 0.58 |
HDL-Cholesterol (mg/dL) | 42 (36–50) | 42 (35–49) | 42 (36–51) | 42 (36–49) | 0.99 |
Triglycerides (mg/dL) | 120 (87–181) | 120 (85–176) | 118 (85–179) | 126 (90–185) | 0.36 |
Fasting Glucose (mg/dL) | 118 (103–149) | 119 (105–150) | 115 (102–143) | 121 (103–152) | 0.54 |
Glycated Hemoglobin (%) | 6.5 (5.8–7.7) | 6.3 (5.8–7.6) | 6.5 (5.9–7.7) | 6.6 (5.9–7.9) | 0.85 |
Hemoglobin (g/dL) | 14.0 (12.9–15.1) | 14.1 (12.9–15.2) | 14.0 (13.0–15.1) | 13.8 (12.6–14.9) | 0.45 |
Troponin (ng/L) | 9.0 (5.0–17.0) | 4.0 (3.0–6.0) | 9.0 (8.0–11.0) | 26.0 (17.0–57.0) | <0.001 |
Group 1 (n = 316) | Group 2 (n = 316) | Group 3 (n = 317) | p-Value * | |
---|---|---|---|---|
HF Hospitalization | 4 (1.3%) | 13 (4.2%) | 25 (8.0%) | <0.001 |
MI | 12 (3.9%) | 5 (1.6%) | 7 (2.3%) | 0.13 |
PCI or CABG | 22 (7.1%) | 18 (5.8%) | 22 (7.1%) | 0.52 |
Death | 19 (6.0%) | 28 (8.9%) | 41 (12.9%) | 0.002 |
Combined Events (Death + Hospitalization) | 22 (7.0%) | 40 (12.8%) | 58 (18.5%) | <0.001 |
Group 1 (Reference) | Group 2 | Group 3 | ||
---|---|---|---|---|
Overall Death | HR (95% CI), p-value | 1.0 | 1.12 (0.60–2.10), p = 0.71 | 2.02 (1.13–3.60), p = 0.017 |
Combined Events | HR (95% CI), p-value | 1.0 | 1.33 (0.77–2.32), p = 0.31 | 2.30 (1.37–3.88), p = 0.002 |
AUC (95% CI) | Sensibility (%) | Specificity (%) | Cut Off (ng/L) | p-Value | |
---|---|---|---|---|---|
Death | 0.619 (0.587–0.650) | 48.9 | 69.7 | >13 | <0.0001 |
Combined Events | 0.645 (0.613–0.675) | 50.8 | 70.8 | >13 | <0.0001 |
AUC (95% CI) | Sensibility (%) | Specificity (%) | Cut Off (Ratio) | p-Value | |
---|---|---|---|---|---|
Death | 0.611 (0.579–0.642) | 53.4 | 66.0 | 0.24 | <0.0001 |
Combined Events | 0.639 (0.607–0.669) | 53.3 | 67.7 | 0.24 | <0.0001 |
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Strunz, C.M.C.; Hueb, W.; Rezende, P.C.; Vendramini, S.P.d.A.; Assis, A.C.R.d.; Roggerio, A.; Tairova, M.S.; Silva, M.F.; Oliveira, S.A.; Kisser, G.d.C.A.; et al. High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study. Int. J. Mol. Sci. 2023, 24, 17286. https://doi.org/10.3390/ijms242417286
Strunz CMC, Hueb W, Rezende PC, Vendramini SPdA, Assis ACRd, Roggerio A, Tairova MS, Silva MF, Oliveira SA, Kisser GdCA, et al. High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study. International Journal of Molecular Sciences. 2023; 24(24):17286. https://doi.org/10.3390/ijms242417286
Chicago/Turabian StyleStrunz, Celia Maria Cassaro, Whady Hueb, Paulo Cury Rezende, Sabrina Pacheco do Amaral Vendramini, Arthur Cicupira Rodrigues de Assis, Alessandra Roggerio, Maria Stanislavovna Tairova, Marcela Francisca Silva, Senili Avila Oliveira, Gyovanna de Cassia Agreste Kisser, and et al. 2023. "High-Sensitivity Troponin I and Cardiovascular Events in Stable Coronary Artery Disease: Insights from a Longitudinal Outpatient Study" International Journal of Molecular Sciences 24, no. 24: 17286. https://doi.org/10.3390/ijms242417286