Special Issue "Recent Advance on Fluorine Chemistry"
Deadline for manuscript submissions: 29 February 2024 | Viewed by 1396
Interests: trifluoromethanesulfonamides; bis(trifluoromethanesulfonyl)imide; triflates; selective fluorination; oxidative reactions; amination
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Fluorine is a unique element due to its introduction as a substituent in various classes of chemical compounds. The uniqueness of fluorine lies in the special polarizing and steric properties of the fluorine atom, which surprisingly affects the chemical and physical properties of molecules. Such specific features affect all stages of work and research on fluorine-containing structures: unique methodologies for the synthesis and analysis of fluorine-containing compounds, the study of the biochemical mechanisms of the action of such compounds on living systems, the study of the synthesis and structure of new materials, etc. Among fluorine compounds, several general groups can be distinguished: complex and inorganic fluorine derivatives, as well as a wide class of organic fluorine-containing compounds. The latter, as a rule, are divided into weakly fluorinated (containing one or more isolated fluorine-containing substituents, for example, CH2F, CF2, CF3) and polyfluorinated (or perfluoro-) derivatives. Surprisingly, fluorine and many of its derivatives are extremely toxic substances for humans, but at the same time, fluorine is necessary for human health. Organic fluorine compounds are very rare in nature, only about three dozen such substances are known (for example, fluoroacetic acid, fluoroacetone, ω-fluorooleic acid). All these natural organofluorine compounds are extremely toxic. Despite the fact that natural fluorine-containing substances are very few in number, synthetic organofluorine derivatives are a very important objects of research, and the organic chemistry of fluorine is completely created by humans. Although elemental fluorine is toxic to all living things, fluorine-containing drugs are increasingly used in medical practice (about a third of all agrochemicals and pharmaceuticals produced contain at least one fluorine atom). Of the special sign drugs, examples such as Celebrex, Perftoran, Fluoxetine, Atorvastatin can be cited. The introduction of fluorine changes the physical, chemical, and biological properties of the initial compound due to conformational changes, changes in acid–base properties, and the ability to form hydrogen bonds, which play an important role in biological systems. Fluorine derivatives simultaneously have both high hydrophilicity and good lipophilicity, as well as high stability and chemical inertness to metabolic degradation, which makes it possible to reduce the dose of the drug. Thus, fluorine-containing compounds are important and interesting objects for research in the field of biochemistry, molecular chemistry, medicine, and pharmacy. To that end, this Special Issue of the International Journal of Molecular Sciences, Recent Advance on Fluorine Chemistry, will include original research papers and reviews on the latest developments in fluorine chemistry.
Dr. Mikhail Moskalik
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- оrganofluorine compounds
- fluorine-containing building blocks
- fluorine introduction
- fluorine NMR
- fluorine biocatalysis
- fluorine drugs