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Molecular Research on Neuronal Cell Death and Neurogenesis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 1706

Special Issue Editor


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Guest Editor
1. Department of Biological Applications and Technologies, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
2. Biomedical Research Institute, Foundation for Research and Technology-Hellas, 45500 Ioannina, Greece
Interests: molecular biology; programmed cell death; neurogenesis
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Special Issue Information

Dear Colleagues,

Neurogenesis is the process by which cells of the nervous system, called neurons, are generated from neural stem cells (NSCs). In 1842, Karl Vogt first noted the requirement for physiological cell death when studying metamorphosis of amphibians. Neuronal cell death was first noticed as a loss of neurons during development. Neuronal death is normal during nervous system development but is abnormal in brain and spinal cord disease and injury. Neuronal cell death occurs extensively during development and pathology. We now know that neurons die in at least a dozen ways, including apoptosis and necrosis, etc. A better understanding of the molecular mechanisms of neuronal cell death in nervous system development, injury and disease can lead to new therapeutic approaches for the prevention of neurodegeneration and neurological disabilities and will expand the field of cell death biology.

The purpose of this special issue is to present the latest research on the molecular mechanisms of neuronal cell death and neurogenesis, and the available evidence suggesting a possible role of different forms of cell death in the pathogenesis of neurological diseases. Both original research articles and comprehensive reviews are welcomed.

Dr. Theologos Michaelidis
Guest Editor

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Published Papers (1 paper)

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Review

24 pages, 384 KiB  
Review
Neuroprotection during Thrombectomy for Acute Ischemic Stroke: A Review of Future Therapies
by Vikalpa Dammavalam, Sandra Lin, Sayedatun Nessa, Neil Daksla, Kamil Stefanowski, Ana Costa and Sergio Bergese
Int. J. Mol. Sci. 2024, 25(2), 891; https://doi.org/10.3390/ijms25020891 - 10 Jan 2024
Cited by 1 | Viewed by 1417
Abstract
Stroke is a major cause of death and disability worldwide. Endovascular thrombectomy has been impactful in decreasing mortality. However, many clinical results continue to show suboptimal functional outcomes despite high recanalization rates. This gap in recanalization and symptomatic improvement suggests a need for [...] Read more.
Stroke is a major cause of death and disability worldwide. Endovascular thrombectomy has been impactful in decreasing mortality. However, many clinical results continue to show suboptimal functional outcomes despite high recanalization rates. This gap in recanalization and symptomatic improvement suggests a need for adjunctive therapies in post-thrombectomy care. With greater insight into ischemia-reperfusion injury, recent preclinical testing of neuroprotective agents has shifted towards preventing oxidative stress through upregulation of antioxidants and downstream effectors, with positive results. Advances in multiple neuroprotective therapies, including uric acid, activated protein C, nerinetide, otaplimastat, imatinib, verapamil, butylphthalide, edaravone, nelonemdaz, ApTOLL, regional hypothermia, remote ischemic conditioning, normobaric oxygen, and especially nuclear factor erythroid 2-related factor 2, have promising evidence for improving stroke care. Sedation and blood pressure management in endovascular thrombectomy also play crucial roles in improved stroke outcomes. A hand-in-hand approach with both endovascular therapy and neuroprotection may be the key to targeting disability due to stroke. Full article
(This article belongs to the Special Issue Molecular Research on Neuronal Cell Death and Neurogenesis)
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