Beyond Compatibility: Unraveling the Molecular Dynamics of Biomaterial-Host Interactions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: 20 May 2024 | Viewed by 1830
Special Issue Editor
Special Issue Information
Dear Colleagues,
Biomaterials, including bioactive ceramics, polymers, silk, and composites, have long been used in a multitude of medical applications, from implants to drug delivery platforms and regenerative medicine. While these materials have been widely acknowledged for their biocompatibility and bioactivity, the complex interplay between the biomaterials and host biological systems at the molecular level remains largely unexplored. Biomaterial‒host interaction is a critical determinant in the successful integration of these materials into the body, affecting everything from tissue regeneration to the risk of infection and inflammation. Furthermore, with the escalating problem of antibiotic resistance worldwide, it is essential to move beyond the simplistic paradigm of mere biocompatibility and delve into the molecular dynamics that underlie these interactions.
The investigation of biomaterial‒host interactions at a molecular level brings new challenges and opportunities. The use of advanced analytical techniques and simulation models will be crucial in gaining insights into these complex interactions. Moreover, understanding the role of surface modifications, such as the addition of antimicrobial compounds or bioactive molecules, in modulating these interactions could lead to the development of biomaterials with enhanced therapeutic efficacy and safety.
This Special Issue, presided by Dr. Samuel J. Lin as Guest Editor and Dr. Jose Antonio Foppiani as Publicity Editor, invites cutting-edge research papers and comprehensive reviews from materials scientists, biomedical engineers, cell biologists, biochemists, and clinicians who are at the forefront of this intriguing research frontier. The objective is to further our understanding of the molecular dynamics that dictate the interaction of biomaterials with host tissues, thereby advancing the development of next-generation biomaterials that not only exhibit biocompatibility but also actively interact with the biological milieu to promote healing and prevent infections. This deeper knowledge will set the stage for a more effective use of biomaterials in clinical settings, leading to improved patient outcomes.
Dr. Samuel J Lin
Guest Editor
Manuscript Submission Information
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Keywords
- molecular dynamics
- biomaterial‒host interactions
- biofilms
- bacteria‒host interaction
- chronic inflammation
- rejection
