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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Transglutaminase 2 and Cellular Functions submission deadline 30 May 2024 | 7 articles | Viewed by 8355 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Alzheimer’s Disease: From Pathogenesis to Treatment
edited by
submission deadline 30 May 2024 | 7 articles | Viewed by 8249 | Submission Open
Keywords: Alzheimer’ s disease; neurodegeneration; neurotransmitter; Aβ ; Tau; neuroinflammation; behavioral symptoms; symptomatic treatment; DMT
(This special issue belongs to the Section Molecular Neurobiology)
Cell Biology in Diabetes and Diabetic Complications submission deadline 30 May 2024 | 4 articles | Viewed by 7984 | Submission Open
Keywords: diabetes; obesity; insulin resistance; hypertension; diabetic nephropathy
(This special issue belongs to the Section Molecular Biology)
Amyotrophic Lateral Sclerosis as a Systemic Disease 2.0
edited by
submission deadline 30 May 2024 | 4 articles | Viewed by 7851 | Submission Open
Keywords: neurogenic muscle atrophy; retrograde signals; crosstalk; multi-system biomarkers; neuroinflammation; neurodegeneration; hypermetabolism
(This special issue belongs to the Section Molecular Neurobiology)
Plant Defense Response to Microbial, Herbivorous, and Environmental Interactions
edited by
submission deadline 30 May 2024 | 4 articles | Viewed by 7738 | Submission Open
Keywords: plant pathogenic infections; insect pest damage; abiotic stress; plant/microbial chemical signaling; innate immunity; systemic acquired resistance (SAR); pathogen-related proteins; plant defense enzymes; plant growth hormones
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of mRNA Transcriptional Regulation: 2nd Edition submission deadline 30 May 2024 | 5 articles | Viewed by 7597 | Submission Open
Keywords: transcriptoion factors (TFs); cis-regulatory elements (CREs); long non-coding RNAs (lncRNAs); short non-coding RNAs (sncRNAs); small nuclear RNAs (snRNAs); microRNA (miRNA); circular RNA (circRNA); DNA methylation; chromatin regulators
(This special issue belongs to the Section Biochemistry)
Biocatalysis and Bioactive Molecules: Future and Development submission deadline 30 May 2024 | 5 articles | Viewed by 7505 | Submission Open
Keywords: enzymatic synthesis; renewable sources; biocatalysis; enzymes; bioactive molecules; green chemistry; bioprocess; green catalysis; biotechnology; agro-industrial waste; immobilization; green solvent
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Advances in Analytical Techniques for Biological and Medical Research
edited by
submission deadline 30 May 2024 | 4 articles | Viewed by 7454 | Submission Open
Keywords: HPLC; GC; electrophoresis; mass spectrometry; plant materials; validation; metabolomics; proteomics; protein– ligand interaction
(This special issue belongs to the Section Molecular Biology)
Bioactive Lipids: From the Perspective of Cellular and Molecular Mechanisms submission deadline 30 May 2024 | 5 articles | Viewed by 7193 | Submission Open
Keywords: lipids; polyunsaturated fatty acids; lipid metabolism; lipid mediators; inflammation; neuroprotection
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Pathophysiology to Novel Therapeutic Approaches for Leukemia
edited by
submission deadline 30 May 2024 | 5 articles | Viewed by 6661 | Submission Open
Keywords: acute myeloid leukemia; acute lymphoblastic leukemia; molecular pathophysiology; new therapeutic approaches; immunotherapy; cellular therapy; allogenic bone marrow transplantation
(This special issue belongs to the Section Molecular Oncology)
Exploring Molecular Mechanisms of Inflammatory Diseases
edited by
submission deadline 30 May 2024 | 3 articles | Viewed by 6532 | Submission Open
Keywords: immunity; inflammation; inflammatory disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Studies on Lactic Acid Bacteria and Their Products in Health and Diseases 2.0 submission deadline 30 May 2024 | 5 articles | Viewed by 6472 | Submission Open
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Biochemical and Molecular Changes in the Brain Caused by Drug Abuse: Implications for Therapeutic Intervention submission deadline 30 May 2024 | 6 articles | Viewed by 6451 | Submission Open
Keywords: substance use disorder; pharmacotherapy; addiction; relapse; vulnerability; drug self-administration; craving
(This special issue belongs to the Section Molecular Pharmacology)
Retinal Diseases and Macular Degeneration: Cell Biology and Molecular Genetics submission deadline 30 May 2024 | 4 articles | Viewed by 6054 | Submission Open
Keywords: retinal dystrophies; omics sciences; neurophysiology; molecular pathways; genetics and biology of retinal diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurometabolic Disorders in the Adults submission deadline 30 May 2024 | 2 articles | Viewed by 5790 | Submission Open
Keywords: Neurometabolic; Metabolic/biochemical pathways; Genetic defects; Pathological phenotypes
(This special issue belongs to the Section Molecular Neurobiology)
Microbial Omics
edited by
submission deadline 30 May 2024 | 5 articles | Viewed by 5747 | Submission Open
Keywords: omics technologies; omics methodologies; microorganisms; proteomics; genomics; transcriptomics
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances in New Combination Therapies for Cancer
edited by Valeria Lucarini and
submission deadline 30 May 2024 | 5 articles | Viewed by 5684 | Submission Open
Keywords: immunotherapy; target therapy; chemotherapy; tumor microenvironment; combination therapies; preclinical models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Stress Signaling and Programmed Cell Death 2.0
edited by
submission deadline 30 May 2024 | 5 articles | Viewed by 5541 | Submission Open
Keywords: apoptosis; non-apoptotic cell death; inflammatory cell death; cancer; neurodegenerative disease.
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and New Therapies for Breast Cancer
edited by Mary Lou Cutler and
submission deadline 30 May 2024 | 5 articles | Viewed by 5446 | Submission Open
Keywords: management of metastatic disease; neoadjuvant therapy; chemotherapy and immunotherapy combination; novel biologics; aromatase inhibitors; outcome research; quality of life during and after breast cancer therapy; new targets for TNBC
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tissue Engineering and Cell Therapy: Recent Progress
edited by
submission deadline 30 May 2024 | 3 articles | Viewed by 5076 | Submission Open
Keywords: biomaterials and cell sources for tissue engineering and cell therapy; tissue engineering of substitutes in vitro; functional testing of tissues reconstructed in vitro; extracellular matrix; mechanical characteristics; biological and histological characterization; translational research
(This special issue belongs to the Section Biochemistry)
Metal-Organic Coordination Compounds: Synthesis, Structure, Spectra, Applications submission deadline 30 May 2024 | 5 articles | Viewed by 4830 | Submission Open
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Programmed Cell Death and Oxidative Stress 2.0
edited by
submission deadline 30 May 2024 | 6 articles | Viewed by 4669 | Submission Open
Keywords: oxidative stress; programmed cell death; cellular stresses; senescence; cytotoxicity; cancer; neurodegenerative disease; inflammatory disease; organelle stress
(This special issue belongs to the Section Biochemistry)
Human and Animal Monocytes and Macrophages in Homeostasis and Disease 5.0 submission deadline 30 May 2024 | 5 articles | Viewed by 4568 | Submission Open
Keywords: monocytes; macrophages; inflammation; diseases; COVID-19; diabetes mellitus; polarity; phagocytosis; cytokine secretion; chemotaxis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Extracellular Vesicles in Immunology
edited by and Valeria Longo
submission deadline 30 May 2024 | 3 articles | Viewed by 4299 | Submission Open
(This special issue belongs to the Section Molecular Immunology)
Mass Spectrometry in Molecular Biology
edited by
submission deadline 30 May 2024 | 3 articles | Viewed by 4237 | Submission Open
Keywords: mass spectrometry of biomolecules; native/modified peptides; proteins; lipids; and metabolites; sample preparation; extraction; and ionization techniques; ion fragmentation pattern recognition; statistical analysis of identification results
(This special issue belongs to the Section Molecular Informatics)
Physiology and Pathology of Neurons 2.0
edited by
submission deadline 30 May 2024 | 3 articles | Viewed by 3862 | Submission Open
(This special issue belongs to the Section Molecular Neurobiology)
Drug Resistance in Cancer: Molecular Mechanisms and Tackling Strategies 2.0
edited by
submission deadline 30 May 2024 | 3 articles | Viewed by 3758 | Submission Open
Keywords: apoptosis; cancer; clinical trials; chemotherapy; drug metabolism; drug resistance; drug delivery; heterogeneity; immunotherapy; microenvironment
(This special issue belongs to the Section Molecular Pharmacology)
Current Research on Cancer Biology and Therapeutics 2.0 submission deadline 30 May 2024 | 4 articles | Viewed by 3636 | Submission Open
Keywords: antiangiogenic; anticancer therapy; antimetastatic; apoptosis; antiproliferative; cancer; peptides; signaling molecules; transcription factors; tumor
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Angiogenesis and Cancer
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 3532 | Submission Open
Keywords: angiogenesis; cancer; tumor angiogenesis; VEGF signaling; VEGFR2; HIF1a; transcription factors; anti-angiogenesis; anti-angiogenic therapy; angiogenesis inhibitors; endothelia cells; tumor associated Endothelial cells; metastasis; hypoxia; cancer differentiation; cancer stem cells; endothelial cell differentiation
(This special issue belongs to the Section Molecular Oncology)
New Insights in Natural Bioactive Compounds 3.0 submission deadline 30 May 2024 | 4 articles | Viewed by 3502 | Submission Open
Keywords: inflammation; cytokines; ROS; oxidative stress; natural products; flavonoids; cannabinoids
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research on Plant-Associated Nitrogen-Fixing Bacteria
edited by
submission deadline 30 May 2024 | 3 articles | Viewed by 3383 | Submission Open
Keywords: plants; microbes; rhizobia; frankia; symbiosis; chemical biology; interspecific interactions; nitrogen fixation
(This special issue belongs to the Section Molecular Plant Sciences)
Photo(electro)catalysts: Design, Synthesis and Molecular Applications
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 3308 | Submission Open
Keywords: catalyst; photocatalyst; photo(electro)catalyst; electrocatalyst; nanomaterials; CO2 and N2 reduction; H2; H2O2 production
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Metallo-Proteins: Structure, Function and Their Roles in Health and Disease
edited by , Luigi Russo and
submission deadline 30 May 2024 | 2 articles | Viewed by 3172 | Submission Open
Keywords: metal-binding proteins: structure; function and properties; protein folding and dynamics; metal ions exposure; uptake; toxicity; coordination complex formation; signal transduction; molecular recognition; abnormal metal-protein complex formations; environmental contaminants; mechanisms of action and effects on human health; metallo-proteins as drug targets
(This special issue belongs to the Section Molecular Biophysics)
Muscle Proteins, Functions and Interactions
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 3152 | Submission Open
Keywords: muscle contraction; muscle regulation; myosin; actin; titin; troponin; tropomyosin; Z-line; M-line; sarcomere
(This special issue belongs to the Section Molecular Biophysics)
Molecular Research in Bacterial Vaginosis submission deadline 30 May 2024 | 2 articles | Viewed by 3133 | Submission Open
Keywords: bacterial vaginosis; biofilms; genital infections; molecular diagnostics; recurrent bacterial vaginosis; molecular research; Gardnerella vaginalis; sequencing; hybridization methods
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Plant Biostimulants
edited by and Julietta Moustaka
submission deadline 30 May 2024 | 2 articles | Viewed by 3016 | Submission Open
Keywords: biostimulants; abiotic stresses; biotic stresses; plant growth promoter; stress acclimation; oxidative damage; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Role of Cytokines and Their Receptors in Human Tumors and Immune-Regulation
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 3003 | Submission Open
Keywords: cytokines; cytokine receptors; immune regulation; cytokine expression regulation; tumorogenesis; tumor development
(This special issue belongs to the Section Molecular Immunology)
State-of-the-Art Molecular Neurobiology in Chile 2.0
edited by
submission deadline 30 May 2024 | 3 articles | Viewed by 2897 | Submission Open
Keywords: neurological disorders; neurodegeneration; pharmacology; protein structure; neuroinflammation; neurophysiology
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Therapies of Colorectal Cancer 3.0 submission deadline 30 May 2024 | 4 articles | Viewed by 2889 | Submission Open
Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine
(This special issue belongs to the Section Molecular Oncology)
Bioactive Nanoparticles: Synthesis and Potential Applications
edited by Gopiraman Mayakrishnan, and
submission deadline 30 May 2024 | 3 articles | Viewed by 2876 | Submission Open
Keywords: biomaterials; nanoparticles; biomedical; biosensing; bio-catalysis
(This special issue belongs to the Section Molecular Nanoscience)
Melatonin in Plant: From Molecular Basis to Functional Application
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 2850 | Submission Open
Keywords: melatonin; phytohormone; cellular signaling; redox molecule; homeostasis; crop application; circadian ryhthm
(This special issue belongs to the Section Molecular Plant Sciences)
Ion Channels in the Nervous System
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 2848 | Submission Open
Keywords: voltage-gated ion channels; ligand-gated ion channels; neurons; glia cells; electrical activity; molecular structure; molecular pathway
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms of Action of Adaptogens—in Search of Natural Methods of Restoring Homeostasis
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 2782 | Submission Open
Keywords: adaptogens; nutraceutical; phytotherapy; stress; homeostasis; anti-inflammatory effects; phytochemicals; anti-oxidants; oxidative stress; nutritional factors; epigenetics; herb
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Lung Cancers: An Update on Molecular Diagnostics and Therapy
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 2679 | Submission Open
Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Viral Infections and Cancer: Recent Advances and Future Perspectives
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 2549 | Submission Open
Keywords: virus; infection; cancer; immune response
(This special issue belongs to the Section Molecular Oncology)
Molecular Progression of Genome-Related Diseases submission deadline 30 May 2024 | 3 articles | Viewed by 2443 | Submission Open
Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health
(This special issue belongs to the Section Molecular Genetics and Genomics)
Essential Metals in Neurological Diseases and Cancer
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 2309 | Submission Open
Keywords: neurodegenerative disorders; cancer; essential metals; Alzheimer’ s disease; psychiatric disordes; copper; iron; zinc
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Reprogramming the Tumor Microenvironment in Pancreatic Cancer
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 2272 | Submission Open
(This special issue belongs to the Section Molecular Oncology)
Functional Polymeric Materials: From Synthesis to Applications submission deadline 30 May 2024 | 4 articles | Viewed by 2046 | Submission Open
Keywords: natural polymers; bio-based polymers; block copolymers; micelles; polymer chemistry; (hydro)gels; (bio)applications; degradability
(This special issue belongs to the Section Materials Science)
Theoretical Calculations in Materials Sciences: Molecular Structure and Spectra
edited by
submission deadline 30 May 2024 | 2 articles | Viewed by 2045 | Submission Open
Keywords: molecular structure; nature of chemical bonding; IR spectra; EA spectra; NMR; XRD; DFT; ab initio
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
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