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Functional Polymeric Materials: From Synthesis to Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 3214

Special Issue Editors


E-Mail Website
Guest Editor
Institute of Polymer Science and Technology (ICTP-CSIC), 28006 Madrid, Spain
Interests: polymer coatings; antimicrobial coatings; biointerfaces; porous surfaces; functional surfaces superhydrophobicity; bioapplications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the upcoming Special Issue of IJMS, focusing on the molecular science of functional polymeric materials on topics from synthesis techniques to applications. We invite leading experts in the field to contribute high-quality papers to this collection, which aims to highlight new developments in the molecular science of functional polymeric materials. This Issue will encompass research on the synthesis or modification of these polymers, as well as the analysis of their chemical, optical, electrical, biological, and biomedical properties. Furthermore, we seek to explore their applications as smart materials, sensors, membranes, and coatings, in energy storage, and in other areas.

Given the growing interest in this area within the scientific community, we encourage the submission of various types of manuscripts, including original articles, reviews, and short communications. All articles should be focusing on the latest research into functional polymers from a molecular perspective.

Dr. Marta Fernández-García
Dr. Alexandra Muñoz-Bonilla
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural polymers
  • bio-based polymers
  • block copolymers
  • micelles
  • polymer chemistry
  • (hydro)gels
  • (bio)applications
  • degradability

Published Papers (5 papers)

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Research

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14 pages, 2032 KiB  
Article
Molecular Design Using Selected Concentration Effects in Optically Activated Fluorescent Matrices
by Aneta Lewkowicz, Katarzyna Walczewska-Szewc, Martyna Czarnomska, Emilia Gruszczyńska, Mattia Pierpaoli, Robert Bogdanowicz and Zygmunt Gryczyński
Int. J. Mol. Sci. 2024, 25(9), 4804; https://doi.org/10.3390/ijms25094804 - 28 Apr 2024
Viewed by 477
Abstract
Molecular physics plays a pivotal role in various fields, including medicine, pharmaceuticals, and broader industrial applications. This study aims to enhance the methods for producing specific optically active materials with distinct spectroscopic properties at the molecular level, which are crucial for these sectors, [...] Read more.
Molecular physics plays a pivotal role in various fields, including medicine, pharmaceuticals, and broader industrial applications. This study aims to enhance the methods for producing specific optically active materials with distinct spectroscopic properties at the molecular level, which are crucial for these sectors, while prioritizing human safety in both production and application. Forensic science, a significant socio-economic field, often employs hazardous substances in analyzing friction ridges on porous surfaces, posing safety concerns. In response, we formulated novel, non-toxic procedures for examining paper evidence, particularly thermal papers. Our laboratory model utilizes a polyvinyl alcohol polymer as a rigid matrix to emulate the thermal paper’s environment, enabling precise control over the spectroscopic characteristics of 1,8-diazafluoro-9-one (DFO). We identified and analyzed the cyclodimer 1,8-diazafluoren-9-one (DAK DFO), which is a non-toxic and biocompatible alternative for revealing forensic marks. The reagents used to preserve fingerprints were optimized for their effectiveness and stability. Using stationary absorption and emission spectroscopy, along with time-resolved emission studies, we verified the spectroscopic attributes of the new structures under deliberate aggregation conditions. Raman spectroscopy and quantum mechanical computations substantiated the cyclodimer’s configuration. The investigation provides robust scientific endorsement for the novel compound and its structural diversity, influenced by the solvatochromic sensitivity of the DFO precursor. Our approach to monitoring aggregation processes signifies a substantial shift in synthetic research paradigms, leveraging simple chemistry to yield an innovative contribution to forensic science methodologies. Full article
(This article belongs to the Special Issue Functional Polymeric Materials: From Synthesis to Applications)
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23 pages, 8977 KiB  
Article
Molecularly Imprinted Drug Carrier for Lamotrigine—Design, Synthesis, and Characterization of Physicochemical Parameters
by Monika Sobiech, Sandile M. Khamanga, Karol Synoradzki, Tamara J. Bednarchuk, Katarzyna Sikora, Piotr Luliński and Joanna Giebułtowicz
Int. J. Mol. Sci. 2024, 25(9), 4605; https://doi.org/10.3390/ijms25094605 - 23 Apr 2024
Viewed by 386
Abstract
This study presents the initial attempt at introducing a magnetic molecularly imprinted polymer (MIP) designed specifically for lamotrigine with the purpose of functioning as a drug carrier. First, the composition of the magnetic polymer underwent optimization based on bulk polymer adsorption studies and [...] Read more.
This study presents the initial attempt at introducing a magnetic molecularly imprinted polymer (MIP) designed specifically for lamotrigine with the purpose of functioning as a drug carrier. First, the composition of the magnetic polymer underwent optimization based on bulk polymer adsorption studies and theoretical analyses. The magnetic MIP was synthesized from itaconic acid and ethylene glycol dimethacrylate exhibiting a drug loading capacity of 3.4 ± 0.9 μg g−1. Structural characterization was performed using powder X-ray diffraction analysis, vibrating sample magnetometry, and Fourier transform infrared spectroscopy. The resulting MIP demonstrated controlled drug released characteristics without a burst effect in the phospahe buffer saline at pH 5 and 8. These findings hold promise for the potential nasal administration of lamotrigine in future applications. Full article
(This article belongs to the Special Issue Functional Polymeric Materials: From Synthesis to Applications)
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21 pages, 4781 KiB  
Article
Exploration of the Delivery of Oncolytic Newcastle Disease Virus by Gelatin Methacryloyl Microneedles
by Qiang Zhang, Jintong Na, Xiyu Liu and Jian He
Int. J. Mol. Sci. 2024, 25(4), 2353; https://doi.org/10.3390/ijms25042353 - 16 Feb 2024
Viewed by 959
Abstract
Oncolytic Newcastle disease virus is a new type of cancer immunotherapy drug. This paper proposes a scheme for delivering oncolytic viruses using hydrogel microneedles. Gelatin methacryloyl (GelMA) was synthesized by chemical grafting, and GelMA microneedles encapsulating oncolytic Newcastle disease virus (NDV) were prepared [...] Read more.
Oncolytic Newcastle disease virus is a new type of cancer immunotherapy drug. This paper proposes a scheme for delivering oncolytic viruses using hydrogel microneedles. Gelatin methacryloyl (GelMA) was synthesized by chemical grafting, and GelMA microneedles encapsulating oncolytic Newcastle disease virus (NDV) were prepared by micro-molding and photocrosslinking. The release and expression of NDV were tested by immunofluorescence and hemagglutination experiments. The experiments proved that GelMA was successfully synthesized and had hydrogel characteristics. NDV was evenly dispersed in the allantoic fluid without agglomeration, showing a characteristic virus morphology. NDV particle size was 257.4 ± 1.4 nm, zeta potential was −13.8 ± 0.5 mV, virus titer TCID50 was 107.5/mL, and PFU was 2 × 107/mL, which had a selective killing effect on human liver cancer cells in a dose and time-dependent manner. The NDV@GelMA microneedles were arranged in an orderly cone array, with uniform height and complete needle shape. The distribution of virus-like particles was observed on the surface. GelMA microneedles could successfully penetrate 5% agarose gel and nude mouse skin. Optimal preparation conditions were freeze-drying. We successfully prepared GelMA hydrogel microneedles containing NDV, which could effectively encapsulate NDV but did not detect the release of NDV. Full article
(This article belongs to the Special Issue Functional Polymeric Materials: From Synthesis to Applications)
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Review

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25 pages, 12537 KiB  
Review
Porous Hydrogels for Immunomodulatory Applications
by Cuifang Wu, Honghong Zhang, Yangyang Guo, Xiaomin Sun, Zuquan Hu, Lijing Teng and Zhu Zeng
Int. J. Mol. Sci. 2024, 25(10), 5152; https://doi.org/10.3390/ijms25105152 - 9 May 2024
Viewed by 356
Abstract
Cancer immunotherapy relies on the insight that the immune system can be used to defend against malignant cells. The aim of cancer immunotherapy is to utilize, modulate, activate, and train the immune system to amplify antitumor T-cell immunity. In parallel, the immune system [...] Read more.
Cancer immunotherapy relies on the insight that the immune system can be used to defend against malignant cells. The aim of cancer immunotherapy is to utilize, modulate, activate, and train the immune system to amplify antitumor T-cell immunity. In parallel, the immune system response to damaged tissue is also crucial in determining the success or failure of an implant. Due to their extracellular matrix mimetics and tunable chemical or physical performance, hydrogels are promising platforms for building immunomodulatory microenvironments for realizing cancer therapy and tissue regeneration. However, submicron or nanosized pore structures within hydrogels are not favorable for modulating immune cell function, such as cell invasion, migration, and immunophenotype. In contrast, hydrogels with a porous structure not only allow for nutrient transportation and metabolite discharge but also offer more space for realizing cell function. In this review, the design strategies and influencing factors of porous hydrogels for cancer therapy and tissue regeneration are first discussed. Second, the immunomodulatory effects and therapeutic outcomes of different porous hydrogels for cancer immunotherapy and tissue regeneration are highlighted. Beyond that, this review highlights the effects of pore size on immune function and potential signal transduction. Finally, the remaining challenges and perspectives of immunomodulatory porous hydrogels are discussed. Full article
(This article belongs to the Special Issue Functional Polymeric Materials: From Synthesis to Applications)
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28 pages, 8050 KiB  
Review
Polyethersulfone Polymer for Biomedical Applications and Biotechnology
by Monika Wasyłeczko, Cezary Wojciechowski and Andrzej Chwojnowski
Int. J. Mol. Sci. 2024, 25(8), 4233; https://doi.org/10.3390/ijms25084233 - 11 Apr 2024
Viewed by 573
Abstract
Polymers stand out as promising materials extensively employed in biomedicine and biotechnology. Their versatile applications owe much to the field of tissue engineering, which seamlessly integrates materials engineering with medical science. In medicine, biomaterials serve as prototypes for organ development and as implants [...] Read more.
Polymers stand out as promising materials extensively employed in biomedicine and biotechnology. Their versatile applications owe much to the field of tissue engineering, which seamlessly integrates materials engineering with medical science. In medicine, biomaterials serve as prototypes for organ development and as implants or scaffolds to facilitate body regeneration. With the growing demand for innovative solutions, synthetic and hybrid polymer materials, such as polyethersulfone, are gaining traction. This article offers a concise characterization of polyethersulfone followed by an exploration of its diverse applications in medical and biotechnological realms. It concludes by summarizing the significant roles of polyethersulfone in advancing both medicine and biotechnology, as outlined in the accompanying table. Full article
(This article belongs to the Special Issue Functional Polymeric Materials: From Synthesis to Applications)
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