Drug Resistance in Cancer: Molecular Mechanisms and Tackling Strategies 2.0
Deadline for manuscript submissions: 30 May 2024 | Viewed by 1860
Interests: drug resistance; Ewing sarcoma; ovarian cancer; ABCB1; LSD1; TP53
Special Issues, Collections and Topics in MDPI journals
Cancer is a highly complex, adaptive condition that can rapidly develop new phenotypic and genotypic profiles to circumvent therapy. Drug resistance threatens the longevity of drugs and restricts the treatment options for patients, and it is highly common in oncology and infectious diseases. The emergence of drug resistance remains the largest impediment in the quest for a curative cancer treatment, with an estimated 90% of all cancer-related deaths being attributed to chemoresistance. The rapidity with which cancer cells can develop resistance to both classical chemotherapy and targeted agents is startling. With the knowledge that each cubic centimeter of a tumour contains up to one billion cancer cells, novel insights into both primary and acquired resistance mechanisms, including drug detoxification, alterations in drug targets, genomic/epigenetic instability, increased ability to repair DNA damage, reduced susceptibility to apoptosis, as well as the influence of the tumour microenvironment and clonal cooperation, are required to substantially alter therapeutic treatment practices and increase the overall survival rates. Some of these resistance pathways lead to multidrug resistance, generating an increasingly challenging clinical problem.
This Special Issue of IJMS will highlight the recent advances in drug resistance, particularly novel mechanisms and targeted strategies to tackle this global medicine concern. Experimental papers, up-to-date review articles, and commentaries are all welcome.
Dr. Kathleen Pishas
Manuscript Submission Information
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- clinical trials
- drug metabolism
- drug resistance
- drug delivery