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Special Issue "Bioactive Nanoparticles: Synthesis and Potential Applications"

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 30 March 2024 | Viewed by 1199

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Special Issue Editors

Dr. Gopiraman Mayakrishnan
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Guest Editor

Nano Fusion Technology Research Group, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University, Tokida 3-15-1, Ueda, Nagano 386-8567, Japan
Interests: materials chemistry; nanofibers, carbon materials, nanocatalysis, supercapacitor, biomedical; sensors

Prof. Dr. Ick-Soo Kim

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Guest Editor

Nano Fusion Technology Research Group, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University, Tokida 3-15-1, Ueda, Nagano 386-8567, Japan
Interests: nanofibers; electrospinning; bio-medical; sensors; carbon materials; food packing; nano-catalysis; supercapacitor; drug delivery
Special Issues, Collections and Topics in MDPI journals

Dr. Vanaraj Ramkumar

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Guest Editor

Materials Chemistry Laboratory, School of Chemical Engineering, Yeungnam University, Gyeonsan 38541, Republic of Korea
Interests: MOF; supercapacitor; organic electronics; biomedical; sensors; carbon materials; nanocomposites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive nanoparticles can significantly influence interactions with biological systems. They often exhibit unique bioactivities owing to their nanoscale size effect, well-defined architecture, and precise surface property. Without doubt, bioactive nanoparticles have represented an important and exciting area of research. Bioactive nanoparticles can be inorganic, organic, inorganic–organic hybrid, carbon-based composites, polymeric, or supramolecular-based materials. Synthetic methods have significant effect on the physicochemical properties of the bioactive nanoparticles. Recently, there has been growing interest in the potential use of bioactive nanoparticles in bio-catalysis, biosensing, imaging, hemostasis, cancer immunotherapy, bone regeneration, wound dressing, and so on. In this light, the aim of this Special Issue is to generate discussion on the latest advances in research on the synthesis and potential applications of bioactive nanoparticles.

Topics of interest include but are not limited to:

Synthesis of bioactive nanoparticles;
Inorganic bioactive nanoparticles;
Polymetric nanoparticles;
Carbon-based nanoparticles;
Biosensing;
Bio-catalysis;
Drug release;
Wound healing;
Cancer;
Anti-microbial;
Disease treatment;
Hemostasis;
Bioimaging;
Bone regeneration;
Neurodegenerative disease therapy.

Dr. Gopiraman Mayakrishnan
Prof. Dr. Ick-Soo Kim
Dr. Vanaraj Ramkumar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

biomaterials
nanoparticles
biomedical
biosensing
bio-catalysis

Published Papers (2 papers)

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Research

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15 pages, 3926 KiB

Open AccessArticle

Cytotoxic-Ag-Modified Eggshell Membrane Nanocomposites as Bactericides in Concrete Mortar

Samuel Tomi Aina

Hilda Dinah Kyomuhimbo

and

Int. J. Mol. Sci. 2023, 24(20), 15463; https://doi.org/10.3390/ijms242015463 - 23 Oct 2023

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Abstract

Against the backdrop of escalating infrastructure budgets worldwide, a notable portion—up to 45%—is allocated to maintenance endeavors rather than innovative infrastructure development. A substantial fraction of this maintenance commitment involves combatting concrete degradation due to microbial attacks. In response, this study endeavors to propose a remedial strategy employing nano metals and repurposed materials within cement mortar. The methodology entails the adsorption onto eggshell membranes (ESM) of silver nitrate (ESM/AgNO₃) or silver nanoparticles (ESM/AgNPs) yielding silver–eggshell membrane composites. Subsequently, the resulting silver–eggshell membrane composites were introduced in different proportions to replace cement, resulting in the formulation of ten distinct mortar compositions. A thorough analysis encompassing a range of techniques, such as spectrophotometry, scanning electron microscopy, thermogravimetric analysis, X-ray fluorescence analysis, X-ray diffraction (XRD), and MTT assay, was performed on these composite blends. Additionally, evaluations of both compressive and tensile strengths were carried out. The mortar blends 3, 5, and 6, characterized by 2% ESM/AgNO₃, 1% ESM/AgNPs, and 2% ESM/AgNPs cement replacement, respectively, exhibited remarkable antimicrobial efficacy, manifesting in substantial reduction in microbial cell viability (up to 50%) of typical waste activated sludge. Concurrently, a marginal reduction of approximately 10% in compressive strength was noted, juxtaposed with an insignificant change in tensile strength. This investigation sheds light on a promising avenue for addressing concrete deterioration while navigating the balance between material performance and structural integrity. Full article

(This article belongs to the Special Issue Bioactive Nanoparticles: Synthesis and Potential Applications)

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60 pages, 30540 KiB

Open AccessReview

Cationic Materials for Gene Therapy: A Look Back to the Birth and Development of 2,2-Bis-(hydroxymethyl)Propanoic Acid-Based Dendrimer Scaffolds

Silvana Alfei

Int. J. Mol. Sci. 2023, 24(21), 16006; https://doi.org/10.3390/ijms242116006 - 06 Nov 2023

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Abstract

Gene therapy is extensively studied as a realistic and promising therapeutic approach for treating inherited and acquired diseases by repairing defective genes through introducing (transfection) the “healthy” genetic material in the diseased cells. To succeed, the proper DNA or RNA fragments need efficient vectors, and viruses are endowed with excellent transfection efficiency and have been extensively exploited. Due to several drawbacks related to their use, nonviral cationic materials, including lipidic, polymeric, and dendrimer vectors capable of electrostatically interacting with anionic phosphate groups of genetic material, represent appealing alternative options to viral carriers. Particularly, dendrimers are highly branched, nanosized synthetic polymers characterized by a globular structure, low polydispersity index, presence of internal cavities, and a large number of peripheral functional groups exploitable to bind cationic moieties. Dendrimers are successful in several biomedical applications and are currently extensively studied for nonviral gene delivery. Among dendrimers, those derived by 2,2-bis(hydroxymethyl)propanoic acid (b-HMPA), having, unlike PAMAMs, a neutral polyester-based scaffold, could be particularly good-looking due to their degradability in vivo. Here, an overview of gene therapy, its objectives and challenges, and the main cationic materials studied for transporting and delivering genetic materials have been reported. Subsequently, due to their high potential for application in vivo, we have focused on the biodegradable dendrimer scaffolds, telling the history of the birth and development of b-HMPA-derived dendrimers. Finally, thanks to a personal experience in the synthesis of b-HMPA-based dendrimers, our contribution to this field has been described. In particular, we have enriched this work by reporting about the b-HMPA-based derivatives peripherally functionalized with amino acids prepared by us in recent years, thus rendering this paper original and different from the existing reviews. Full article

(This article belongs to the Special Issue Bioactive Nanoparticles: Synthesis and Potential Applications)

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Special Issue "Bioactive Nanoparticles: Synthesis and Potential Applications"

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