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Relationship of Micronutrients and Dietary Components with Metabolic Dysfunction-Associated Steatotic...
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Relationship of Micronutrients and Dietary Components with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 641

Special Issue Editors

Dr. Weiwen Chai

E-Mail Website
Guest Editor
Department of Nutrition and Health Sciences, University of Nebraska—Lincoln, 1700 N 35th Street, Lincoln, NE 68583, USA
Interests: clinical and behavioral intervention studies in adults and children; nutritional epidemiology and dietary analyses within large cohorts; assessment of nutrition intervention; multiple publications related to obesity, cancer and ethnic differences in disease risk; analyses examining nutritional and inflammatory biomarkers with the risk of chronic diseases
Dr. Sathish Kumar Natarajan

E-Mail Website
Guest Editor
Department of Nutrition and Health Sciences, College of Education and Human Sciences, University of Nebraska at Lincoln, Lincoln, NE 68583, USA
Interests: maternal obesity; placental lipotoxicity; metabolic dysfunction-associated steatotic liver disease; apoptosis; liver cirrhosis; proline metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The purpose of this Special Issue, “Relationship of Micronutrients and Dietary Components with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)”, is to publish a focused, coherent, impactful, and well-cited volume on how micronutrients and other dietary components influence metabolic dysfunction-associated steatotic liver disease (MASLD) such as their roles in preventing and treating MASLD and investigations on the underlying mechanisms. Micronutrients play important roles in reducing inflammation and oxidative stress as well as in metabolism and maintaining tissue functions. Thus, elucidating the relationships and underlying mechanisms of micronutrients and other dietary components on MASLD (newly defined; steatotic liver disease with the presence of at least one of five cardiometabolic risk factors) would help prevent and treat MASLD. The goal of this Special Issue is to provide rigorous evidence from novel experimental, clinical, and observational studies that support the associations or influences of micronutrients and other dietary components on MASLD. Articles of basic science nature, animal studies, clinical/translational studies, epidemiological studies, meta-analyses, and behavioral studies are acceptable. Potential topics include, but are not limited to, the following:

  1. Effects or associations of dietary micronutrients and other dietary components or supplements or circulating micronutrients on MASLD.
  2. Effects of dietary micronutrients and other components on inflammation in MASLD.
  3. Protective role of dietary micronutrients and other components of diet against the development of MASLD.
  4. Cellular, molecular, and epigenetic pathways that reflect how micronutrients and other dietary components influence MASLD.

Dr. Weiwen Chai
Dr. Sathish Kumar Natarajan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • micronutrients
  • dietary components
  • metabolic dysfunction-associated steatotic liver disease (MASLD)
  • inflammation in MASLD
  • gut microbiome with MASLD
  • pathogenesis of MASLD
  • roles of micronutrients in MASLD

Published Papers (1 paper)

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Research

11 pages, 255 KiB  
Article
Overall and Sex-Specific Associations of Serum Lipid-Soluble Micronutrients with Metabolic Dysfunction-Associated Steatotic Liver Disease among Adults in the United States
by Weiwen Chai and Meng-Hua Tao
Nutrients 2024, 16(8), 1242; https://doi.org/10.3390/nu16081242 - 22 Apr 2024
Viewed by 530
Abstract
This study examined overall and sex-specific associations of serum lipid-soluble micronutrients including α- and γ-tocopherols, 25-hydroxy-vitamin D (25(OH)D), retinol, and six major carotenoids with metabolic dysfunction-associated steatotic lever disease (MASLD) using the 2017–2018 National Health and Nutrition Examination Survey. This analysis included 3956 [...] Read more.
This study examined overall and sex-specific associations of serum lipid-soluble micronutrients including α- and γ-tocopherols, 25-hydroxy-vitamin D (25(OH)D), retinol, and six major carotenoids with metabolic dysfunction-associated steatotic lever disease (MASLD) using the 2017–2018 National Health and Nutrition Examination Survey. This analysis included 3956 adults (1991 men, 1965 women) aged ≥ 20 years. Steatotic liver disease was determined through transient elastography examination. Odds ratios (ORs) and 95% confidence intervals (95% CIs) for MASLD associated with micronutrients were estimated using logistic regressions. Higher serum α-tocopherol (highest vs. lowest quartile: OR = 1.53, 95% CI = 1.05–2.22, p = 0.03) and γ-tocopherol (highest vs. lowest quartile: OR = 4.15, 95% CI = 3.00–5.74, p < 0.0001) levels were associated with increased odds of MASLD. Higher serum 25(OH)D levels were associated with reduced odds of MASLD (highest vs. lowest quartile: OR = 0.41, 95% CI = 0.27–0.61, p = 0.0001). Inverse associations with the condition were also observed for carotenoids (α-carotene, β-carotene, α-cryptoxanthin, β-cryptoxanthin, combined lutein and zeaxanthin, and lycopene) in the serum (Ps < 0.05). The results were comparable between men and women, except for those on α-tocopherol, for which a positive association was only observed for men (p = 0.01). Our results suggest potential protective associations of serum 25(OH)D and carotenoids with MASLD. The positive associations between tocopherols and MASLD may reflect pathophysiological conditions associated with the condition. Full article
(This article belongs to the Special Issue Relationship of Micronutrients and Dietary Components with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD))
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