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Special Issue "Current Progress in Surface, Micromorphology and Mechanical Properties of Implants"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 February 2024 | Viewed by 669

Special Issue Editors

Department of Neurosciences, Reproduction and Odontostomatological Sciences, University of Naples Federico II Via S. Pansini 5, 80131 Napoli, Italy
Interests: osseointegration; tissue regeneration; platelet concentrates; implant surface; implant aesthetics
Special Issues, Collections and Topics in MDPI journals
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, 80131 Naples, Italy
Interests: oral medicine; dental materials; operative dentistry; oral health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Osseointegration is a prerequisite for the success of dental implants. The fixture surfaces should ensure cell adhesion, proliferation, and differentiation to form healthy peri-implant bone. Immediately after their positioning, dental implants are soaked with the patient's blood, followed by a rapid adsorption of ions and plasma proteins onto the surface of the implant, forming a protein layer. This dynamic process is governed by complex noncovalent interactions, such as hydrogen bonding, electrostatic forces, hydrophobic interactions and van der Waals forces. Other key factors influencing protein adsorption include surface properties (roughness, chemistry, and surface energy), the availability and profile of biomolecules at the surface (size, charge, and conformational stability) and kinetic factors (concentration and size). The surface topography, chemical–physical, and chemical properties of dental implants play a pivotal role in the healing process, speeding up final restorations and functional loading even in sites with poor bone quality and in patients with unbalanced health conditions.

This Special Issue will address advances in surface micro-topography on cell responses, protein adsorption, and/or antimicrobial properties, focusing on the emerging concepts regarding the role of fixture macro-morphology and surface chemistry, topographical patterns at the micro- and nano-scale, and addressing fast and successful osseo- and soft tissue integration.

Studies on surface micro- and micro-morphology, surface functionalization, and chemical and mechanical properties and their related effects on cells responses and on clinical outcomes are welcome.

Prof. Dr. Gaetano Marenzi
Prof. Dr. Gianrico Spagnuolo
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • surface micro-topography
  • biocompatibility
  • contact angle
  • surface characterization
  • cell adhesion
  • protein adhesion
  • osteoblast differentiation
  • osseointegration
  • hydrophilic

Published Papers (1 paper)

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17 pages, 16592 KiB  
The Impact of Al2O3 Particles from Grit-Blasted Ti6Al7Nb (Alloy) Implant Surfaces on Biocompatibility, Aseptic Loosening, and Infection
Materials 2023, 16(21), 6867; - 26 Oct 2023
Viewed by 522
For the improvement of surface roughness, titanium joint arthroplasty (TJA) components are grit-blasted with Al2O3 (corundum) particles during manufacturing. There is an acute concern, particularly with uncemented implants, about polymeric, metallic, and corundum debris generation and accumulation in TJA, and [...] Read more.
For the improvement of surface roughness, titanium joint arthroplasty (TJA) components are grit-blasted with Al2O3 (corundum) particles during manufacturing. There is an acute concern, particularly with uncemented implants, about polymeric, metallic, and corundum debris generation and accumulation in TJA, and its association with osteolysis and implant loosening. The surface morphology, chemistry, phase analysis, and surface chemistry of retrieved and new Al2O3 grit-blasted titanium alloy were determined with scanning electron microscopy (SEM), X-ray energy-dispersive spectroscopy (EDS), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and confocal laser fluorescence microscopy, respectively. Peri-prosthetic soft tissue was studied with histopathology. Blasted retrieved and new stems were exposed to human mesenchymal stromal stem cells (BMSCs) for 7 days to test biocompatibility and cytotoxicity. We found metallic particles in the peri-prosthetic soft tissue. Ti6Al7Nb with the residual Al2O3 particles exhibited a low cytotoxic effect while polished titanium and ceramic disks exhibited no cytotoxic effect. None of the tested materials caused cell death or even a zone of inhibition. Our results indicate a possible biological effect of the blasting debris; however, we found no significant toxicity with these materials. Further studies on the optimal size and properties of the blasting particles are indicated for minimizing their adverse biological effects. Full article
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