Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
5.9
Journals
Nutrients
Special Issues
Lipid Metabolism and Nutrition Status in Gestational Diabetes Mellitus
share announcement

Lipid Metabolism and Nutrition Status in Gestational Diabetes Mellitus

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition in Women".

Deadline for manuscript submissions: 5 October 2024 | Viewed by 3899

Special Issue Editor

Prof. Dr. Xuefeng Yang

E-Mail Website
Guest Editor
Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Interests: population-based birth cohort studies that examine the associations between dietary factors (nutrients, food groups and dietary patterns); gene–diet interactions with pregnancy outcomes; animal or cell model studies that investigate the mechanisms of chronic metabolic disorders (obesity, metabolic syndrome, insulin resistance and type 2 diabetes) by using new approaches in nutrigenomics and in metabolomics

Special Issue Information

Dear Colleagues,

The Special Issue aims to encourage submissions of high-quality articles on the topic of lipid metabolism and nutrition status in pregnancy. Complex changes occur in lipid metabolism during pregnancy to fulfill both maternal requirements for lipid stores and energy reserves and as lipid substrates required by the fetus. Hyperlipidemia during pregnancy contributes to insulin resistance and the development of gestational diabetes mellitus (GDM). GDM pregnancies are also associated with dyslipidemia. Although the causal relationships between dyslipidemia and GDM have not yet been determined, they both increase the risk of adverse pregnancy outcomes, such as macrosomia and the susceptibility of cardiovascular diseases and other metabolic disorders during later life for mothers and their offspring.

This Special Issue welcomes articles of any type that focus on the alterations of lipid metabolism, placental transfer of lipids in normal pregnancies and GDM, their associations with pregnancy outcomes and long-term health of mothers and their fetus and the potential mechanisms underlying these associations. Submissions related to the evaluation of nutritional status during pregnancy by traditional approaches or innovative strategies, such as metabolomics/lipidomics, are also of interest.

Prof. Dr. Xuefeng Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipid metabolism
  • gestational diabetes mellitus
  • pregnancy outcomes
  • pregnancy
  • dyslipidemia
  • hyperglycemia
  • insulin resistance
  • placenta
  • nutrition status

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

21 pages, 3864 KiB  
Article
Intergenerational Hyperglycemia Impairs Mitochondrial Function and Follicular Development and Causes Oxidative Stress in Rat Ovaries Independent of the Consumption of a High-Fat Diet
by Verônyca Gonçalves Paula, Yuri Karen Sinzato, Franciane Quintanilha Gallego, Larissa Lopes Cruz, Ariana Musa de Aquino, Wellerson Rodrigo Scarano, José Eduardo Corrente, Gustavo Tadeu Volpato and Débora Cristina Damasceno
Nutrients 2023, 15(20), 4407; https://doi.org/10.3390/nu15204407 - 17 Oct 2023
Cited by 1 | Viewed by 1048
Abstract
We analyzed the influence of maternal hyperglycemia and the post-weaning consumption of a high-fat diet on the mitochondrial function and ovarian development of the adult pups of diabetic rats. Female rats received citrate buffer (Control–C) or Streptozotocin (for diabetes induction–D) on postnatal day [...] Read more.
We analyzed the influence of maternal hyperglycemia and the post-weaning consumption of a high-fat diet on the mitochondrial function and ovarian development of the adult pups of diabetic rats. Female rats received citrate buffer (Control–C) or Streptozotocin (for diabetes induction–D) on postnatal day 5. These adult rats were mated to obtain female pups (O) from control dams (OC) or from diabetic dams (OD), and they received a standard diet (SD) or high-fat diet (HFD) from weaning to adulthood and were distributed into OC/SD, OC/HFD, OD/SD, and OD/HFD. In adulthood, the OGTT and AUC were performed. These rats were anesthetized and euthanized for sample collection. A high percentage of diabetic rats were found to be in the OD/HFD group (OD/HFD 40% vs. OC/SD 0% p < 0.05). Progesterone concentrations were lower in the experimental groups (OC/HFD 0.40 ± 0.04; OD/SD 0.30 ± 0.03; OD/HFD 0.24 ± 0.04 vs. OC/SD 0.45 ± 0.03 p < 0.0001). There was a lower expression of MFF (OD/SD 0.34 ± 0.33; OD/HFD 0.29 ± 0.2 vs. OC/SD 1.0 ± 0.41 p = 0.0015) and MFN2 in the OD/SD and OD/HFD groups (OD/SD 0.41 ± 0.21; OD/HFD 0.77 ± 0.18 vs. OC/SD 1.0 ± 0.45 p = 0.0037). The number of follicles was lower in the OD/SD and OD/HFD groups. A lower staining intensity for SOD and Catalase and higher staining intensity for MDA were found in ovarian cells in the OC/HFD, OD/SD, and OD/HFD groups. Fetal programming was responsible for mitochondrial dysfunction, ovarian reserve loss, and oxidative stress; the association of maternal diabetes with an HFD was responsible for the higher occurrence of diabetes in female adult pups. Full article
(This article belongs to the Special Issue Lipid Metabolism and Nutrition Status in Gestational Diabetes Mellitus)
►▼ Show Figures

Figure 1

12 pages, 994 KiB  
Article
Pregnancy Cholesterol Metabolism Markers and the Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study
by Yan Li, Yuanjue Wu, Yanyan Ge, Shanshan Huang, Yang Yang, Zhen Zhang, Ningning Cui, Junan Yan, Yonggang Li, Ping Luo, Liping Hao, Guoping Xiong and Xuefeng Yang
Nutrients 2023, 15(17), 3809; https://doi.org/10.3390/nu15173809 - 31 Aug 2023
Viewed by 997
Abstract
This study aims to determine the association of pregnancy cholesterol metabolism markers with gestational diabetes mellitus (GDM) risk. We performed a nested case–control study in the Tongji Birth Cohort. GDM was diagnosed according to the 75 g 2 h oral glucose tolerance test [...] Read more.
This study aims to determine the association of pregnancy cholesterol metabolism markers with gestational diabetes mellitus (GDM) risk. We performed a nested case–control study in the Tongji Birth Cohort. GDM was diagnosed according to the 75 g 2 h oral glucose tolerance test (OGTT) at 24–28 gestational weeks. Nine cholesterol metabolism markers were detected using gas chromatography-mass spectrometry. Conditional logistic regression models were conducted. A total of 444 pregnant women were matched in a 1:2 ratio. The cholestanolTC and β-sitosterolTC in cholesterol absorption markers presented negative associations with the risks of GDM (adjusted OR: 0.77, 95% CI: 0.61–0.96; adjusted OR: 0.80, 95% CI: 0.64–1.00). The desmosterolTC in cholesterol synthesis markers were positively associated with the risks of GDM (adjusted OR: 1.25, 95% CI: 1.00–1.56), similar in the ratios of cholesterol synthesis to absorption markers. After adjustment for insulin or HOMA-IR, these effects were reduced. In conclusion, higher cholesterol synthesis and lower cholesterol absorption marker levels in the first pregnancy are associated with a higher risk of GDM, and insulin resistance may play a vital role in this association. Full article
(This article belongs to the Special Issue Lipid Metabolism and Nutrition Status in Gestational Diabetes Mellitus)
►▼ Show Figures

Figure 1

22 pages, 20641 KiB  
Article
Maternal n-7 Unsaturated Fatty Acids Protect the Fetal Brain from Neuronal Degeneration in an Intrauterine Hyperglycemic Animal Model
by Haruka Okami, Ritsuko Kawaharada, Hitomi Yoshizaki, Akiyo Toriumi, Saki Tsutsumi and Akio Nakamura
Nutrients 2023, 15(15), 3434; https://doi.org/10.3390/nu15153434 - 03 Aug 2023
Cited by 1 | Viewed by 1215
Abstract
We previously reported that glycation induces insulin resistance in the hearts of newborn pups from a gestational diabetes mellitus (GDM) rat model. Administration of n-3 unsaturated fatty acids suppressed glycation and improved signaling in GDM rat pups. In this study, we investigated their [...] Read more.
We previously reported that glycation induces insulin resistance in the hearts of newborn pups from a gestational diabetes mellitus (GDM) rat model. Administration of n-3 unsaturated fatty acids suppressed glycation and improved signaling in GDM rat pups. In this study, we investigated their effects on cranial neurons using the GDM rat model and PC12 cells derived from rat adrenal pheochromocytomas. Additionally, we examined whether n-3 and n-7 unsaturated fatty acids (cis-palmitoleic acid [CPA] and trans-palmitoleic acid [TPA]) ameliorate the detrimental effects of high glucose exposure on rats. In the neonatal cerebrum of GDM rats, increased levels of advanced glycation end products (AGEs) inhibited Akt phosphorylation; however, CPA and TPA intake during pregnancy ameliorated these abnormalities. Furthermore, exposure to high-glucose-induced apoptosis in PC12 cells compared to the cells cultured in control glucose. PC12 cells exposed to high-glucose with fatty acids exhibited reduced AGE production and apoptosis induction compared to the high-glucose group. These findings suggest that a hyperglycemic environment during pregnancy promotes AGE formation in brain neuronal proteins and induces apoptosis. Both TPA and CPA mitigated these abnormalities; however, CPA is cytotoxic, highlighting its safety in pregnant women. Full article
(This article belongs to the Special Issue Lipid Metabolism and Nutrition Status in Gestational Diabetes Mellitus)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop