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Impact of Bioactive Compounds on Metabolic and Cardiovascular Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (28 March 2023) | Viewed by 3522

Special Issue Editors


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Guest Editor
1. Richardson Center for Food Technology and Research, Winnipeg, MB R3T 2N2, Canada
2. Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
3. Morden Research and Development Centre, Agriculture and Agri-Food Canada, Morden, MB R6M 1Y5, Canada
Interests: cereals; whole grain; nutrition; bioactives; chronic diseases
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Guest Editor
Division of Biochemistry, ICAR-Indian Agricultural Research Institute (IARI), New Delhi, India
Interests: starch quality; food matrix and inherent glycemic potential; nutritional biochemistry

Special Issue Information

Dear Colleagues,

Numerous studies over the years have highlighted the potential health effects of various bioactive components of plants. This research area is still being widely explored, involving wild as well as indigenous plants because of the wide diversity of bioactive components, as well as the various modes of action involved in preventing various chronic illnesses. Researchers have also been able to explore minor food ingredients and metabolites with high bioactivity and their mechanisms of action with the recent developments in extraction methods, analytical techniques, and bioactivity assays.

For this reason, the goal of this Special Issue, “Impact of Bioactive Compounds on Metabolic and Cardiovascular Health”, is to cover research domains related to the potential health benefits of various bioactive molecules from plants. In particular, this Special Issue will emphasize the current knowledge and research developments concerning bioactive molecules, including identification and quantification, methods for their extraction and purification, structure–function relationships, mechanisms of action, bio-availability studies, in vitro, in vivo and human studies for the evaluation of their bioactivity, and physiological outcomes to support metabolic and cardiovascular health benefits.

Potential topics include, but are not limited to, the following:

  • Bioactive molecules and their validated health benefits from indigenous/niche food systems;
  • Novel bioactive molecules and their role in metabolic health;
  • Impact of bioactive components on cardiovascular health;
  • Bioactive moleculess and their role in gut modulation;
  • Health promotion and disease prevention and management.

We cordially invite authors to contribute original articles as well as review articles that will give the readers of Nutrients updated and novel perspectives about bioactive molecules and their impact on human health.

Dr. Sijo Jospeh (Thandapilly)
Dr. Veda Krishnan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • metabolic pathways
  • anti-oxidant
  • anti-inflammatory
  • plant extracts
  • biochemical mechanism
  • signaling pathways
  • bio-availability
  • bio-actives
  • prevention

Published Papers (2 papers)

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Research

18 pages, 5927 KiB  
Article
Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats
by Pema Raj, Karen Sayfee, Liping Yu, Ali Sabra, Champa Wijekoon, Lovemore Malunga, Sijo Joseph Thandapilly and Thomas Netticadan
Nutrients 2023, 15(14), 3180; https://doi.org/10.3390/nu15143180 - 18 Jul 2023
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Abstract
Oats are considered a functional food due to the beneficial health effects associated with their consumption and are suitable to be explored for their ability to prevent or manage chronic disease, such as hypertension. Here, we examined the cardiovascular benefits of an oat [...] Read more.
Oats are considered a functional food due to the beneficial health effects associated with their consumption and are suitable to be explored for their ability to prevent or manage chronic disease, such as hypertension. Here, we examined the cardiovascular benefits of an oat beta-glucan extract in male and female spontaneously hypertensive rats (SHRs) to unravel its sex-specific roles when used with an anti-hypertensive medication, hydrochlorothiazide. Five-week-old male and female SHRs and Wistar–Kyoto (WKY) rats were treated with oat beta-glucan and hydrochlorothiazide for 15 weeks. Twenty-week-old male and female SHRs showed high blood pressure (BP), cardiac remodeling, and cardiac dysfunction. These animals also had significantly increased levels of malondialdehyde (MDA), angiotensin II, and norepinephrine. Treatments with beta-glucan and hydrochlorothiazide were able to differentially prevent high BP, cardiac dysfunction, and alterations in malondialdehyde (MDA), angiotensin II, and norepinephrine in 20-week-old male and female SHRs. To conclude, beta-glucan alone and in combination with hydrochlorothiazide may be a promising a strategy for managing hypertension and related cardiac complications. Full article
(This article belongs to the Special Issue Impact of Bioactive Compounds on Metabolic and Cardiovascular Health)
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15 pages, 1501 KiB  
Article
Convolvulus pluricaulis Choisy’s Extraction, Chemical Characterization and Evaluation of the Potential Effects on Glycaemic Balance in a 3T3-L1 Adipocyte Cell Model
by Elisabetta Melloni, Silvia Grassilli, Arianna Romani, Erika Rimondi, Annalisa Marcuzzi, Enrico Zauli, Paola Secchiero, Guglielmo Paganetto, Alessandra Guerrini, Gianni Sacchetti and Massimo Tacchini
Nutrients 2023, 15(7), 1727; https://doi.org/10.3390/nu15071727 - 31 Mar 2023
Cited by 1 | Viewed by 1746
Abstract
Convolvulus pluricaulis (CP) is a common Indian herb, largely employed in Ayurvedic medicine and known for its neuroprotective and neuroinflammatory action. Its effectiveness against several pathologic/sub-pathologic conditions is widely accepted, but it is not yet completely chemically characterized. In recent years, several researchers [...] Read more.
Convolvulus pluricaulis (CP) is a common Indian herb, largely employed in Ayurvedic medicine and known for its neuroprotective and neuroinflammatory action. Its effectiveness against several pathologic/sub-pathologic conditions is widely accepted, but it is not yet completely chemically characterized. In recent years, several researchers have pointed out the involvement of CP and other Convolvulaceae in lipidic and glucidic metabolism, particularly in the control of hyperlipidaemia and diabetic conditions. In this scenario, the aim of the study was to chemically characterize the medium polarity part of the CP whole plant and its fractions and to shed light on their biological activity in adipocyte differentiation using the 3T3-L1 cell model. Our results demonstrated that the CP extract and fractions could upregulate the adipocyte differentiation through the modulation of the nuclear receptor PPARγ (Peroxisome Proliferator-Activated Receptor γ), broadly recognized as a key regulator of adipocyte differentiation, and the glucose transporter GLUT-4, which is fundamental for cellular glucose uptake and for metabolism control. CP also showed the ability to exert an anti-inflammatory effect, downregulating cytokines such as Rantes, MCP-1, KC, eotaxin, and GM-CSF, which are deeply involved in insulin resistance and glucose intolerance. Taken together, these data suggest that CP could exert a potential beneficial effect on glycemia and could be employed as an anti-diabetic adjuvant or, in any case, a means to better control glucose homeostasis. Full article
(This article belongs to the Special Issue Impact of Bioactive Compounds on Metabolic and Cardiovascular Health)
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