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Nutrients
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Inflammatory Bowel Disease: What Is New in Nutrition Care and...
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Inflammatory Bowel Disease: What Is New in Nutrition Care and What Should We Eat?

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (29 December 2023) | Viewed by 6457

Special Issue Editors

Prof. Dr. Antonio Gasbarrini

E-Mail Website
Guest Editor
1. Dean of the Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, 00168 Rome, Italy
2. Chief of the Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy
Interests: digestive diseases; inflammatory bowel diseases; digestive cancer; gut microbiota, internal medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Emanuele Rinninella

E-Mail Website
Guest Editor
1. Research and Training Center in Human Nutrition, Catholic University of Sacred Heart, 00168 Rome, Italy
2. Clinical Nutrition Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy
Interests: clinical nutrition; perioperative nutrition; body composition; gut microbiota dietary modulation; digestive cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Cintoni

E-Mail Website
Guest Editor
Clinical Nutrition Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy
Interests: body composition; clinical nutrition; disease-related malnutrition; gut microbiota and diet therapy; nutrition in cancer patient
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammatory bowel diseases (IBD) are emerging as global diseases. While novel therapies continuously enrich the medical scenario, nutritional care in this setting remains an unmet need. Despite the role of specific dietary plans and artificial nutrition schemes already being studied, nutrition's role should be further investigated as a cause and remedy. Moreover, due to the heterogeneity of clinical presentation, the nutritional challenges in IBD overcome the dietary requirements, including macro and micronutrient deficiencies, water and electrolytes malabsorption, gut barrier and microbiota alterations, dietary management of the surgical complication, food tolerance, and choice of correct nutritional plans according to specific symptoms. The aim of this Special Issue is to collect cutting-edge evidence on this argument to offer clinicians and scientists a valuable offer of integrative care.

Prof. Dr. Antonio Gasbarrini
Dr. Emanuele Rinninella
Dr. Marco Cintoni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary plans
  • oral nutritional supplements
  • artificial nutrition
  • gut microbiota and gut barrier
  • micronutrients
  • growth retardation
  • food additives
  • disease-related malnutrition

Published Papers (3 papers)

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Research

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15 pages, 1000 KiB  
Article
Nutritional Biomarkers for the Prediction of Response to Anti-TNF-α Therapy in Crohn’s Disease: New Tools for New Approaches
by Fernando Rizzello, Ilaria Maria Saracino, Paolo Gionchetti, Maria Chiara Valerii, Chiara Ricci, Veronica Imbesi, Eleonora Filippone, Irene Bellocchio, Nikolas Konstantine Dussias, Thierry Dervieux and Enzo Spisni
Nutrients 2024, 16(2), 280; https://doi.org/10.3390/nu16020280 - 17 Jan 2024
Cited by 1 | Viewed by 1107
Abstract
Crohn’s disease (CD) is a chronic disorder of the digestive tract characterized by an uncontrolled immune-mediated inflammatory response in genetically predisposed individuals exposed to environmental risk factors. Although diet has been identified as one of the major environmental risk factors, the role of [...] Read more.
Crohn’s disease (CD) is a chronic disorder of the digestive tract characterized by an uncontrolled immune-mediated inflammatory response in genetically predisposed individuals exposed to environmental risk factors. Although diet has been identified as one of the major environmental risk factors, the role of nutrients in the clinical management of CD patients has not yet been fully investigated. In this prospective observational study, fifty-four patients diagnosed with active Crohn’s disease and undergoing anti-TNF-α biological therapy were enrolled and subjected to nutrient intake analysis through a daily food diary. Their nutrient intake and blood values were analyzed before and after 6 months of biological therapy. After 6 months of anti-TNF-α, four patients dropped out of the study, leaving 29 patients in clinical remission and 21 still with active disease that remained the same. The aim of this study was to identify nutrients whose intake or blood values may be associated with patients’ responses to biological therapy. In the diet, patients remaining with active CD showed very similar nutrient dietary intake compared to patients achieving remission except for a trend for lower starting zinc intake, below the reference value. In the blood, instead, patients who did not respond to biological therapy showed significantly lower plasma values of iron and taurine before starting biological anti-TNF-α treatment. Full article
(This article belongs to the Special Issue Inflammatory Bowel Disease: What Is New in Nutrition Care and What Should We Eat?)
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Review

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19 pages, 1156 KiB  
Review
Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives
by Ivan Capobianco, Federica Di Vincenzo, Pierluigi Puca, Guia Becherucci, Maria Chiara Mentella, Valentina Petito and Franco Scaldaferri
Nutrients 2024, 16(3), 351; https://doi.org/10.3390/nu16030351 - 25 Jan 2024
Viewed by 2506
Abstract
Limited knowledge is available about the relationship between food allergies or intolerances and inflammatory bowel disease (IBD). Clinicians frequently encounter patients who report food allergies or intolerances, and gastroenterologists struggle distinguishing between patients with organic disorders and those with functional disorders, which the [...] Read more.
Limited knowledge is available about the relationship between food allergies or intolerances and inflammatory bowel disease (IBD). Clinicians frequently encounter patients who report food allergies or intolerances, and gastroenterologists struggle distinguishing between patients with organic disorders and those with functional disorders, which the patients themselves may associate with specific dietary components. This task becomes even more arduous when managing patients with significant underlying organic conditions, like IBD. The aim of this review is to summarize and emphasize any actual associations between food allergies and intolerances and inflammatory diseases, such as ulcerative colitis and Crohn’s disease. Through a narrative disceptation of the current literature, we highlight the increased prevalence of various food intolerances, including lactose, fructose, histamine, nickel, and non-celiac gluten sensitivity, in individuals with IBD. Additionally, we explore the association between increased epithelial barrier permeability in IBD and the development of food sensitization. By doing so, we aim to enhance clinicians’ awareness of the nutritional management of patients with IBD when facing complaints or evidence of food allergies or intolerances. Full article
(This article belongs to the Special Issue Inflammatory Bowel Disease: What Is New in Nutrition Care and What Should We Eat?)
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30 pages, 835 KiB  
Review
Nutrition, Nutritional Status, Micronutrients Deficiency, and Disease Course of Inflammatory Bowel Disease
by Marco Valvano, Annalisa Capannolo, Nicola Cesaro, Gianpiero Stefanelli, Stefano Fabiani, Sara Frassino, Sabrina Monaco, Marco Magistroni, Angelo Viscido and Giovanni Latella
Nutrients 2023, 15(17), 3824; https://doi.org/10.3390/nu15173824 - 31 Aug 2023
Cited by 1 | Viewed by 2471
Abstract
During the disease course, most Inflammatory Bowel Disease patients present a condition of malnutrition, undernutrition, or even overnutrition. These conditions are mainly due to suboptimal nutritional intake, alterations in nutrient requirements and metabolism, malabsorption, and excessive gastrointestinal losses. A suboptimal nutritional status and [...] Read more.
During the disease course, most Inflammatory Bowel Disease patients present a condition of malnutrition, undernutrition, or even overnutrition. These conditions are mainly due to suboptimal nutritional intake, alterations in nutrient requirements and metabolism, malabsorption, and excessive gastrointestinal losses. A suboptimal nutritional status and low micronutrient serum levels can have a negative impact on both induction and maintenance of remission and on the quality of life of Inflammatory Bowel Disease patients. We performed a systematic review including all the studies evaluating the connection between nutrition, nutrition status (including undernutrition and overnutrition), micronutrient deficiency, and both disease course and therapeutic response in Inflammatory Bowel Disease patients. This systematic review was performed using PubMed/MEDLINE and Scopus. Four main clinical settings concerning the effect of nutrition on disease course in adult Inflammatory Bowel Disease patients were analyzed (induction of remission, maintenance of remission, risk of surgery, post-operative recurrence, and surgery-related complications). Four authors independently reviewed abstracts and manuscripts for eligibility. 6077 articles were found; 762 duplicated studies were removed. Out of 412 full texts analyzed, 227 were included in the review. The evidence summarized in this review showed that many nutritional aspects could be potential targets to induce a better control of symptoms, a deeper remission, and overall improve the quality of life of Inflammatory Bowel Disease patients. Full article
(This article belongs to the Special Issue Inflammatory Bowel Disease: What Is New in Nutrition Care and What Should We Eat?)
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