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Innovation in Biomaterials for Tissue Engineering and Regenerative Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1678

Special Issue Editor

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Guest Editor
Centre for Textile Science and Technology, University of Minho, Campus de Azurém, 4800-058 Guimarães, Portugal
Interests: antimicrobial agents concomitant; synergistic and additive effects surface functionalization; antimicrobial properties; biomedical therapies; bioactive molecules; green synthesis; environmentally friendly; circular economy; waste materials’ second life
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Special Issue Information

Dear Colleagues,

Biomaterials can be used as implantable devices or drug delivery platforms with a significant influence on the patients’ quality of life. Indeed, every year a substantial number of new biomaterials and scaffolding systems are engineered and introduced in the biomedical field with an increased potential for biomedical uses. From specialized polymers and functional groups to inorganic compounds, and, more recently, antimicrobial peptides and natural extracts, different functionalization/modification techniques have been employed to facilitate tissue integration of these innovative biomaterials, while also fighting rejection via antimicrobial activities.

This Special Issue seeks manuscript submissions that further our knowledge and understanding about the most recent innovations in biomaterials for tissue engineering and regenerative medicine. Publications on the chemical modification, transformation, or engineering of such systems via green approaches and with improved regenerative and antimicrobial effects are highly welcome. It is expected that these formulations will provide advantageous performance over the conventional systems, thus improving and facilitating health care.

Dr. Helena Felgueiras
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural and synthetic polymers
  • bioactive agents
  • antimicrobial activity
  • regenerative properties
  • tissue regeneration
  • biocompatibility
  • biodegradation
  • tissue integration

Published Papers (1 paper)

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15 pages, 865 KiB  
The Model of Interstitial Cystitis for Evaluating New Molecular Strategies of Interstitial Regeneration in Humans
by Elisabetta Mormone, Antonio Cisternino, Lorenzo Capone, Eugenio Caradonna and Andrea Sbarbati
Int. J. Mol. Sci. 2024, 25(4), 2326; https://doi.org/10.3390/ijms25042326 - 15 Feb 2024
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Given the recent evidence in the clinical application of regenerative medicine, mostly on integumentary systems, we focused our interests on recent bladder regeneration approaches based on mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and hyaluronic acid (HA) in the treatment of interstitial cystitis/bladder [...] Read more.
Given the recent evidence in the clinical application of regenerative medicine, mostly on integumentary systems, we focused our interests on recent bladder regeneration approaches based on mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and hyaluronic acid (HA) in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) in humans. IC/BPS is a heterogeneous chronic disease with not-well-understood etiology, characterized by suprapubic pain related to bladder filling and urothelium dysfunction, in which the impairment of immunological processes seems to play an important role. The histopathological features of IC include ulceration of the mucosa, edema, denuded urothelium, and increased detection of mast cells and other inflammatory cells. A deeper understanding of the molecular mechanism underlying this disease is essential for the selection of the right therapeutic approach. In fact, although various therapeutic strategies exist, no efficient therapy for IC/BPS has been discovered yet. This review gives an overview of the clinical and pathological features of IC/BPS, with a particular focus on the molecular pathways involved and a special interest in the ongoing few investigational therapies in IC/BPS, which use new regenerative medicine approaches, and their synergetic combination. Good knowledge of the molecular aspects related to stem cell-, PRP-, and biomaterial-based treatments, as well as the understanding of the molecular mechanism of this pathology, will allow for the selection of the right and best use of regenerative approaches of structures involving connective tissue and epithelia, as well as in other diseases. Full article
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