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Nutritional Implications of Non-coding RNA for Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 4822

Special Issue Editors

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Guest Editor
Department of Health Science, School of Medicine, University of Catanzaro, 88100 Catanzaro, Italy
Interests: antimicrobial use in urogenital infections; pharmacological treatment of impotence and urogenital diseases; drug treatment in patients in poly-therapy; nutrients

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Co-Guest Editor

Special Issue Information

Dear Colleagues,

In the last two decades, interest in the field of non-coding RNAs has increased due to their regulatory role in two-thirds of human transcriptional output. Although several classes of non-coding RNAs can be found in nature, microRNAs take central stage due to their pleiotropic, biochemical, and pharmacological roles and, importantly, their role in human nutrition.

In this Special Issue, we aim to present a collection of papers dealing with the interaction between nutrition and microRNA expression, the presence of dietary non-coding RNAs, and the potential implications of non-coding RNAs for human health, without ruling out polytherapy in the elderly. We also aim to provide an overview of the state-of-the-art in this field and to bring to the attention of readers the issues that will need to be resolved in this field in the near future.

Prof. Dr. Luca Gallelli
Dr. Erika Cione
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nutrition
  • dietary habits
  • non-coding RNAs
  • dietary microRNAs
  • elderly
  • polytherapy

Published Papers (1 paper)

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13 pages, 2083 KiB  
Expression of Telomeric Repeat–Containing RNA Decreases in Sarcopenia and Increases after Exercise and Nutrition Intervention
by Ke-Vin Chang, Yu-Chen Chen, Wei-Ting Wu, Hong-Jhin Shen, Kuo-Chin Huang, Hsueh-Ping Chu and Der-Sheng Han
Nutrients 2020, 12(12), 3766; - 8 Dec 2020
Cited by 14 | Viewed by 4149
Sarcopenia is defined as aging-related loss of muscle mass and function. Telomere length in chromosomes shortens with age and is modulated by telomeric repeat-containing RNA (TERRA). This study aimed to explore the impact of aging and sarcopenia on telomere length and TERRA expression, [...] Read more.
Sarcopenia is defined as aging-related loss of muscle mass and function. Telomere length in chromosomes shortens with age and is modulated by telomeric repeat-containing RNA (TERRA). This study aimed to explore the impact of aging and sarcopenia on telomere length and TERRA expression, and changes following strengthening exercise and nutrition intervention (supplement of branched-chain amino acids, calcium and vitamin D3) for 12 weeks in the sarcopenic population. Older adults (≥65 years old) were divided into non-sarcopenic controls (n = 36) and sarcopenic individuals (n = 36) after measurement of grip strength and body composition. The relative telomere length of leukocytes in all research participants was evaluated using the T/S ratio (telomere/single copy gene), and relative TERRA expression of leukocytes was determined by reverse-transcription qPCR (RT-qPCR). Generalized estimating equation (GEE) was used to analyze the influence of sarcopenia and intervention on the outcomes. There was no significant difference in telomere length between control subjects and participants with sarcopenia. TERRA expression was lower in sarcopenic participants compared to that in non-sarcopenic controls (5.18 ± 2.98 vs. 2.51 ± 1.89; p < 0.001). In the sarcopenic group, intervention significantly increased TERRA expression, but not telomere length. The GEE analysis demonstrated that TERRA expression was negatively associated with sarcopenia (β coefficient = −2.705, p < 0.001) but positively associated with intervention (β coefficient = 1.599, p = 0.023). Sarcopenia is associated with a decrease in TERRA expression in leukocytes. Rebound TERRA expression (returning to the level similar to the non-sarcopenic controls) was observed in the sarcopenic group after exercise and nutrition intervention. Future studies are warranted to examine the potential of TERRA as a biomarker for sarcopenia and its subsequent responses to intervention. Full article
(This article belongs to the Special Issue Nutritional Implications of Non-coding RNA for Human Health)
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