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Anemia and Dietary Assessment on Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 21577

Special Issue Editor


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Guest Editor
Already in service at Magna Graecia University of Catanzaro/Pugliese-Ciaccio, Hospital of Catanzaro, Catanzaro, Italy
Interests: anemia; iron deficiency; micronutrients; diet; malnutrition; vitamin B12; folic acid

Special Issue Information

Dear Colleagues,

Anemia is a major public health problem and one of the most common nutritional disorders worldwide. It mainly affects people from developing countries, but it can also affect certain groups in developed nations. Anemia has major consequences for human health, causing severe medical issues and affecting a person’s overall health and wellbeing  in addition to being associated with an increased risk of morbidity and mortality. Therefore, control programs should be implemented in every group of at-risk patients.

The term ‘nutritional anemia’ refers to a pathological condition in which blood hemoglobin concentration drops to an abnormally low level due to an imbalance in food intake. This leads to a deficiency of one or more nutrients. The most frequent forms of deficiency anemias are caused by a lack of the essential nutrients in the diet needed for erythropoiesis such as iron, vitamin B12, and folic acid. However, deficiency of other vitamins as vitamins A, B 2, B 6, C, D, and E, and micronutrients, such as copper, zinc, magnesium, cobalt, and molybdenum, may also contribute.

Anemia caused by iron deficiency is prevalent in certain life periods, such as pregnancy, breast feeding, childhood, and adolescence, when bodily nutritional requirements increase. It can also be found in people following weight loss regimens or post-bariatric surgery, in individuals of low-income classes, or those with comorbid conditions (e.g., incomplete dentition). In the elderly, one third of cases are due to nutritional deficiencies: primarily iron but also folate and vitamin B. Anemia in this latter group will represent a substantial burden for the future, owing to the globally increase in the elderly population. Global data on the prevalence and causes of anemia among the elderlies are limited, but it is well-known that the prevalence of anemia increases with time, starting at the age of 50 years, more commonly in women.  Finally, nutritional anemia, especially due to iron deficiency, might be present in vegetarian individuals in pediatric age, as well as in adults. Eradication of nutritional anemia by an effective intervention must be a priority, requiring attention and action. Although various factors can reduce the risk of anemia, the best and most sustainable strategy for preventing nutritional deficiency is dietary improvement. Investigating the effect of diet on the prevention and treatment of nutritional anemia remains a current topic.

Anemia and diet assessment is a field that involves many specialists, such as hematologists, pediatricians, geriatricians, gynecologists, nutritionists, and epidemiologists. In this Special Issue of Nutrients, we would like to assembles scientific contributions about nutritional anemias and diet assessment in all age groups and in different conditions in order to offer a comprehensive report of the most recent knowledge. Both clinical trials and mini-reviews will be considered and accepted.

Prof. Dr. Roberto Miniero
Guest Editor

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Keywords

  • anemia
  • iron deficiency
  • micronutrients
  • diet
  • malnutrition
  • vitamin B12
  • folic acid

Published Papers (4 papers)

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Research

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13 pages, 682 KiB  
Article
Anemia among Adolescent Girls in West Java, Indonesia: Related Factors and Consequences on the Quality of Life
by Puspa Sari, Dewi Marhaeni Diah Herawati, Meita Dhamayanti and Dany Hilmanto
Nutrients 2022, 14(18), 3777; https://doi.org/10.3390/nu14183777 - 13 Sep 2022
Cited by 6 | Viewed by 4004
Abstract
Anemia in adolescent girls is still a problem in Indonesia. The impact of anemia is quite significant for adolescent health. This study aims to analyze related factors of anemia among adolescent girls, and the effect of anemia on the quality of life. The [...] Read more.
Anemia in adolescent girls is still a problem in Indonesia. The impact of anemia is quite significant for adolescent health. This study aims to analyze related factors of anemia among adolescent girls, and the effect of anemia on the quality of life. The study was conducted in the Soreang District, West Java, Indonesia. This cross-sectional study involved 286 female students (15–19 years). A 24-h recall questionnaire was used to collect the nutrient intake. We use the WHOQOL-BREF to analyze the quality of life. The study assessed height, weight, body mass index (BMI), mid-upper arm circumference (MUAC), and a capillary blood sample to determine hemoglobin levels. Bivariate and multiple logistic regression tests were measured to find the factors most influencing anemia. The prevalence of anemia was 14.3%. Related factors of anemia in this study were: duration of blood show per menses, iron consumption, weight, height, and MUAC. From bivariate analyses, anemia influenced the social relationships domain with p < 0.05. Multivariate logistic regression showed that the most influencing factors for anemia were MUAC and duration of blood per menses. Anemia impacted the social relationships domain. In this study, the two main factors that affected anemia were MUAC and duration of blood each menstrual cycle. Full article
(This article belongs to the Special Issue Anemia and Dietary Assessment on Human Health)
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13 pages, 579 KiB  
Article
Differential Effects of Three Nutritional Supplements on the Nutrient Intake of Pregnant Women Enrolled in a Conditional Cash Transfer Program in Mexico: A Cluster Randomized Trial
by Fabiola Mejía-Rodríguez, Amado D. Quezada-Sánchez, Ignacio Méndez Gómez-Humarán, Raquel García-Feregrino, Armando García-Guerra, Ana Cecilia Fernández-Gaxiola and Lynnette M. Neufeld
Nutrients 2022, 14(15), 3003; https://doi.org/10.3390/nu14153003 - 22 Jul 2022
Cited by 1 | Viewed by 1787
Abstract
Supplementation in malnourished pregnant women should not displace natural healthy foods. Objective: To estimate the differential effects of three nutritional supplements on macro- and micronutrient intake of pregnant women beneficiaries of the conditional cash transfer program Prospera (CCT-POP). Methods: Prospective cluster randomized trial. [...] Read more.
Supplementation in malnourished pregnant women should not displace natural healthy foods. Objective: To estimate the differential effects of three nutritional supplements on macro- and micronutrient intake of pregnant women beneficiaries of the conditional cash transfer program Prospera (CCT-POP). Methods: Prospective cluster randomized trial. Communities were randomly assigned to receive a fortified beverage (Beverage), micronutrient tablets (Tablets), or micronutrient powder (MNP). Pregnant women (at <25 weeks) were recruited. The food frequency questionnaire was applied at 25 and 37 weeks of pregnancy and at one and three months postpartum (mpp). Differential effects of the three supplements on the median change in nutrient intake from baseline to each follow-up stage were estimated. Results: Median change in protein intake from dietary and supplement sources were significantly lower for MNP and Tablets than for Beverages (baseline to 37 w: −7.80 ± 2.90 and −11.54 ± 3.00, respectively; baseline to 1 mpp: −7.34 ± 2.90 for MNP, p < 0.001). Compared to Beverages, median increases were higher for the MNP for vitamins C (31.2 ± 11.7, p < 0.01), E (1.67 ± 0.81, p < 0.05), and B12 (0.83 ± 0.27, p < 0.01) from baseline to 37 wk; from baseline to 1 mpp, there was a higher median increase in B12 (0.55 ± 0.25, p < 0.05) and folate (63.4 ± 24.3, p < 0.01); and from baseline to 3 mpp, a higher median increase in iron (2.38 ± 1.06, p < 0.05) and folate (94.4 ± 38.1, p < 0.05). Conclusions: Intake of micronutrients was higher for MNP and Tablets, likely due to food displacement among Beverage consumers. Although iron bioavailability and absorption inhibitors were not considered for the present analyses, the distribution of Tablets or MNP had several advantages in this context where micronutrient deficiency remains high among pregnant women, but macronutrient intake is generally adequate or even high. Full article
(This article belongs to the Special Issue Anemia and Dietary Assessment on Human Health)
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14 pages, 338 KiB  
Article
Anthropometrics, Hemoglobin Status and Dietary Micronutrient Intake among Tanzanian and Mozambican Pigeon Pea Farmers
by Laila Eleraky, Ramula Issa, Sónia Maciel, Hadijah Mbwana, Constance Rybak, Jan Frank and Wolfgang Stuetz
Nutrients 2022, 14(14), 2914; https://doi.org/10.3390/nu14142914 - 15 Jul 2022
Cited by 1 | Viewed by 1608
Abstract
Inadequate consumption of micronutrient-dense and protein-rich foods such as vegetables, legumes and meat is an important contributing cause for anemia and deficiencies of vitamin A and iron in rural communities of Tanzania and Mozambique. A cross-sectional study was conducted to assess the nutritional [...] Read more.
Inadequate consumption of micronutrient-dense and protein-rich foods such as vegetables, legumes and meat is an important contributing cause for anemia and deficiencies of vitamin A and iron in rural communities of Tanzania and Mozambique. A cross-sectional study was conducted to assess the nutritional status (anthropometrics and hemoglobin) and diets in particular micronutrient intake of female and male pigeon pea farmers from Lindi, Tanzania, and Gurué, the Zambézia province of Mozambique. A total of 1526 farmers (669 from Tanzania, 857 from Mozambique) were studied, of whom 16% were overweight and 35% were anemic. The highest prevalence of overweight and anemia, at 35% and 48%, was observed in Tanzanian and Mozambican women, respectively. Overall, only a small proportion of women and men reached the recommended daily dietary intake of vitamin A (10%), iron (51%) and zinc (44%). Multiple regression models revealed that dark green leafy vegetables (DGLVs) highly predicted vitamin A intake, whereas legumes in Tanzania and starchy plants in Mozambique were actually the dominant sources of vitamin A. Cereals covered over half of the iron and the zinc intake in both countries. An increased consumption of micronutrient-rich DGLVs and legumes, while reducing the high amounts of refined maize or polished rice, is suggested to counteract the high prevalence of anemia and overweight among smallholder farmers in East and South Eastern Africa. Full article
(This article belongs to the Special Issue Anemia and Dietary Assessment on Human Health)

Review

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20 pages, 1865 KiB  
Review
Iron Deficiency Anemia: Efficacy and Limitations of Nutritional and Comprehensive Mitigation Strategies
by Shashi Bhushan Kumar, Shanvanth R. Arnipalli, Priyanka Mehta, Silvia Carrau and Ouliana Ziouzenkova
Nutrients 2022, 14(14), 2976; https://doi.org/10.3390/nu14142976 - 20 Jul 2022
Cited by 34 | Viewed by 13401
Abstract
Iron deficiency anemia (IDA) has reached epidemic proportions in developing countries and has become a major global public health problem, affecting mainly 0–5-year-old children and young women of childbearing age, especially during pregnancy. Iron deficiency can lead to life-threatening loss of red blood [...] Read more.
Iron deficiency anemia (IDA) has reached epidemic proportions in developing countries and has become a major global public health problem, affecting mainly 0–5-year-old children and young women of childbearing age, especially during pregnancy. Iron deficiency can lead to life-threatening loss of red blood cells, muscle function, and energy production. Therefore, the pathogenic features associated with IDA are weakness and impaired growth, motor, and cognitive performance. IDA affects the well-being of the young generation and the economic advancement of developing countries, such as India. The imbalance between iron intake/absorption/storage and iron utilization/loss culminates into IDA. However, numerous strategic programs aimed to increase iron intake have shown that improvement of iron intake alone has not been sufficient to mitigate IDA. Emerging critical risk factors for IDA include a composition of cultural diets, infections, genetics, inflammatory conditions, metabolic diseases, dysbiosis, and socioeconomic parameters. In this review, we discuss numerous IDA mitigation programs in India and their limitations. The new multifactorial mechanism of IDA pathogenesis opens perspectives for the improvement of mitigation programs and relief of IDA in India and worldwide. Full article
(This article belongs to the Special Issue Anemia and Dietary Assessment on Human Health)
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