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Nutrients
Special Issues
The Role of Lipids and Lipid Emulsifiers in Clinical Nutrition
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The Role of Lipids and Lipid Emulsifiers in Clinical Nutrition

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (28 April 2023) | Viewed by 1909

Special Issue Editors

Dr. Phil Ayers

E-Mail Website
Guest Editor
Clinical Pharmacy Services, Mississippi Baptist Medical Center, University of Mississippi, Jackson, MS 39202, USA
Interests: critical care; parenteral nutrition; enteral nutrition; clinical pharmacy services
Dr. Andrew Mays

E-Mail Website
Guest Editor
School of Pharmacy, University of Mississippi Medical Center, Jackson, MS, USA
Interests: nutrition; lipids; lipid emulsifiers; parenteral nutrition

Special Issue Information

Dear Colleagues,

This issue will review the importance of incorporating lipid injectable emulsions (ILE) in parenteral nutrition (PN) formulations. Newer ILE formulations have been recently introduced into practice in the United States. Topics to be addressed in this issue include:

  • Safety and tolerability of available ILE (include filtering);
  • Essential fatty acid deficiency and how to meet essential fatty acid requirements with the newer ILE products;
  • Appropriate dosing of ILEs (peds and adults);
  • How to incorporate the newer ILE products into practice;
  • ILE use in the critically ill patient;
  • ILE use in the acutely ill pediatric patient;
  • The use of ILE products in the home parenteral nutrition patient (peds and adult).

Dr. Phil Ayers
Dr. Andrew Mays
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • parenteral nutrition
  • lipid injectable emulsions
  • essential fatty acid
  • pediatric patient

Published Papers (1 paper)

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Research

14 pages, 2050 KiB  
Article
Molecular Oxygen Levels and Percentages of DNA Damage in TPN Patients
by Karolina Dąbrowska, Zuzanna Zaczek, Mariusz Panczyk, Sylwia Osowska, Paweł Kowalczyk, Karol Kramkowski and Jacek Sobocki
Nutrients 2023, 15(9), 2206; https://doi.org/10.3390/nu15092206 - 06 May 2023
Viewed by 1625
Abstract
Total parenteral nutrition (TPN) is a life-saving therapy for patients with intestinal failure, but it carries the risk of complications, including an increase in liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) after long-term use. Patients receiving chronic TPN are also exposed [...] Read more.
Total parenteral nutrition (TPN) is a life-saving therapy for patients with intestinal failure, but it carries the risk of complications, including an increase in liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) after long-term use. Patients receiving chronic TPN are also exposed to metabolic stress from both the underlying disease and parenteral nutrition. The aim of this study was to compare the concentration of liver transaminases AST and ALT in relation to the rate of oxygen consumption in platelet mitochondria in patients receiving long-term TPN with the degree of oxidative stress induced by lipid emulsions, and to explain their role in cellular energy metabolism and changes in the liver based on the percentage of genomic DNA damage. The study group consisted of 86 TPN patients, while the control group consisted of 86 healthy volunteers who were fed only orally. The results of the study showed that the percentage of molecular oxygen depended on the type of lipid emulsion supplied. Analyzing time on TPN as a factor, we observed a decrease in percentage genomic DNA damage and an increase in percentage molecular oxygen in cells. It remains unclear whether TPN has a direct effect on genomic DNA damage and the level of molecular oxygen in cells during the course of treatment. In conclusion, this study provides important insights into the potential effects of TPN on liver enzymes and cellular metabolism. Further research is needed to better understand the underlying mechanisms and to develop strategies to minimize the risk of complications associated with TPN. Full article
(This article belongs to the Special Issue The Role of Lipids and Lipid Emulsifiers in Clinical Nutrition)
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