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Biological Activity of Food-Derived Peptides and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Proteins and Amino Acids".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 2467

Special Issue Editors

Department of Comparative Biomedicine and Food Science, Polo di Agripolis, Viale dell'Università, 16, 35020 Legnaro, Padova, Italy
Interests: antioxidants; bioactive peptides; bioactive compounds; anti-inflammatory
Special Issues, Collections and Topics in MDPI journals
Department of Comparative Biomedicine and Food Science, Polo di Agripolis, Viale dell'Università, 16, 35020 Legnaro, Padova, Italy
Interests: bionanotechnology; polyphenols; antioxidants

Special Issue Information

Dear Colleagues,

In recent years, chronic and age-related diseases, such as diabetes, cardiovascular disease and obesity, have been gaining increasing relevance. Therefore, new strategies to counteract these pathologies are needed. As matter of fact, bioactive molecules such as bioactive peptides are gaining increasing interest. Bioactive peptides are obtained from different matrices, for example food or food by-products. These molecules are released from the parent protein via various mechanisms, such as gastrointestinal digestion, food processing, fermentation and protein enzymatic hydrolysis. It is known that these molecules exert beneficial effects on human health and on many body functions, beyond their known nutritional value. Bioactive peptides can influence important physiological processes through various activities such as mineral binding, antithrombotic, antimicrobial, antihypertensive, immunomodulatory, opioid, anti-inflammatory and antioxidant.

The relationship between bioactive peptides and human health is noteworthy, and this knowledge can be a starting point for the development of new biotechnological opportunities, allowing the production of new functional foods that can improve human and/or animal health.

The goal of this Special Issue is to publish both recent innovative research advances and review papers on the following topics:

  • The identification of new bioactive peptides released during gastrointestinal digestion, food processing, fermentation and protein enzymatic hydrolysis.
  • The isolation and identification of new bioactive peptides from food matrices and food by-products.
  • Evaluation of the effects of fermented food-derived bioactive peptides (in vitro, in vivo and ex vivo).
  • The role of bioactive peptides in cell signalling related to human health.
  • The development of new nutraceuticals and functional foods with bioactive peptides.

If you are willing to contribute with other related topics, please contact one of the editors.

Dr. Federica Tonolo
Prof. Dr. Fabio Vianello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive peptides
  • human health
  • biological effects

Published Papers (2 papers)

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Research

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18 pages, 10489 KiB  
Article
Sea Cucumber Peptides Ameliorate DSS-Induced Ulcerative Colitis: The Role of the Gut Microbiota, the Intestinal Barrier, and Macrophage Polarization
Nutrients 2023, 15(22), 4813; https://doi.org/10.3390/nu15224813 - 17 Nov 2023
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Abstract
The incidence of ulcerative colitis (UC) is increasing annually. There are few treatments for UC patients, and some drugs have serious side effects. Sea cucumber peptide (SCP) has anti-inflammatory, antioxidant and other biological activities, and various sea cucumber species are in pharmaceutical development. [...] Read more.
The incidence of ulcerative colitis (UC) is increasing annually. There are few treatments for UC patients, and some drugs have serious side effects. Sea cucumber peptide (SCP) has anti-inflammatory, antioxidant and other biological activities, and various sea cucumber species are in pharmaceutical development. However, relevant studies on the effects of SCP on UC progression are still lacking. In this study, a mouse model of acute colitis was induced by 3% dextran sulfate (DSS), and the effect of 500 mg/kg SCP on colitis was investigated. The results showed that SCP can alleviate DSS-induced colon damage and intestinal barrier damage. SCP significantly inhibited the expression of inflammatory factors and oxidative stress in UC mice. SCP reversed the intestinal microbiota dysregulation induced by DSS, inhibited the growth of Sutterella, Prevotella_9 and Escherichia-Shigella harmful bacteria, and increased the abundance of Lachnospiraceae_NK4A136_group. At the same time, SCP treatment significantly inhibited the LPS-induced polarization of M1 macrophages, which may be mediated by two monopeptides, IPGAPGVP and TGPIGPPGSP, via FPR2. In conclusion, SCP can protect against colitis by modulating the intestinal microbiota composition and the intestinal barrier and inhibiting the polarization of M1 macrophages. Full article
(This article belongs to the Special Issue Biological Activity of Food-Derived Peptides and Human Health)
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24 pages, 2196 KiB  
Review
Alpha-Glucosidase Inhibitory Peptides: Sources, Preparations, Identifications, and Action Mechanisms
Nutrients 2023, 15(19), 4267; https://doi.org/10.3390/nu15194267 - 05 Oct 2023
Cited by 1 | Viewed by 1254
Abstract
With the change in people’s lifestyle, diabetes has emerged as a chronic disease that poses a serious threat to human health, alongside tumor, cardiovascular, and cerebrovascular diseases. α-glucosidase inhibitors, which are oral drugs, have proven effective in preventing and managing this disease. Studies [...] Read more.
With the change in people’s lifestyle, diabetes has emerged as a chronic disease that poses a serious threat to human health, alongside tumor, cardiovascular, and cerebrovascular diseases. α-glucosidase inhibitors, which are oral drugs, have proven effective in preventing and managing this disease. Studies have suggested that bioactive peptides could serve as a potential source of α-glucosidase inhibitors. These peptides possess certain hypoglycemic activity and can effectively regulate postprandial blood glucose levels by inhibiting α-glucosidase activity, thus intervening and regulating diabetes. This paper provides a systematic summary of the sources, isolation, purification, bioavailability, and possible mechanisms of α-glucosidase inhibitory peptides. The sources of the α-glucosidase inhibitory peptides were introduced with emphasis on animals, plants, and microorganisms. This paper also points out the problems in the research process of α-glucosidase inhibitory peptide, with a view to providing certain theoretical support for the further study of this peptide. Full article
(This article belongs to the Special Issue Biological Activity of Food-Derived Peptides and Human Health)
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