nutrients-logo

Journal Browser

Journal Browser

Preventive and Therapeutic Nutraceuticals

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 5646

Special Issue Editor


E-Mail Website
Guest Editor
Department of Horticultural Sciences, Texas A&M University, College Station, TX 77843-2133, USA
Interests: secondary metabolism of plants under stress conditions; functional foods and cell molecular targets; postharvest biology and technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutraceuticals and functional foods are attracting attention for their potential preventive and therapeutic effects. Over the past few decades, enormous efforts have been devoted to exploring this exciting new topic, and a large body of preclinical and clinical evidence has been collected. In fact, it has been established that adherence to a healthy diet (i.e., the Mediterranean diet) or a diet supplemented with micronutrients (vitamins or minerals) or products isolated from vegetables (including phytosterols or flavonoids) may help in health and the prevention of chronic diseases.

Currently, many components of plants are well recognized for their beneficial health properties, but many components are still awaiting identification and functional characterization for their optimal use by the food and pharmaceutical industries in the development of new and highly effective medicines. Thus, despite much work that has been conducted, there is clearly room for research in this hot area at the basic, clinical, and epidemiological levels.

This Special Issue calls for original research as well as review articles and meta-analyses that consider a non-traditional use of nutraceuticals.

Prof. Dr. Luis Cisneros-Zevallos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutraceuticals
  • functional foods
  • preventive effects
  • therapeutic effects
  • diet supplement
  • micronutrients

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

20 pages, 2506 KiB  
Article
Effects of Fermented Polygonum cuspidatum on the Skeletal Muscle Functions
by Young-Seon Kim, Ji-Hye Han, Chang-Hoon Lim, Xue-Quan Fang, Hyeock-Soon Jang, Sang-Yun Lee, Woo-Jong Yim and Ji-Hong Lim
Nutrients 2024, 16(2), 305; https://doi.org/10.3390/nu16020305 - 19 Jan 2024
Viewed by 1319
Abstract
Plant extract fermentation is widely employed to enhance the nutritional and pharmaceutical value of functional foods. Polygonum cuspidatum (Pc) contains flavonoids, anthraquinones, and stilbenes, imparting protective effects against inflammatory diseases, cancer, diabetes, and cardiovascular diseases. However, the effects of fermented Pc on skeletal [...] Read more.
Plant extract fermentation is widely employed to enhance the nutritional and pharmaceutical value of functional foods. Polygonum cuspidatum (Pc) contains flavonoids, anthraquinones, and stilbenes, imparting protective effects against inflammatory diseases, cancer, diabetes, and cardiovascular diseases. However, the effects of fermented Pc on skeletal muscle strength remain unexplored. In this study, we generated fermented Pc using a complex of microorganisms containing Lactobacillus spp. (McPc) and assessed its effects on muscle strength and motor function in mice. Compared to unfermented Pc water extract, elevated levels of emodin and resveratrol were noted in McPc. This was identified and quantified using UPLC-QTOF/MS and HPLC techniques. Gene expression profiling through RNA-seq and quantitative RT-PCR revealed that McPc administration upregulated the expression of genes associated with antioxidants, glycolysis, oxidative phosphorylation, fatty acid oxidation, and mitochondrial biogenesis in cultured C2C12 myotubes and the gastrocnemius muscle in mice. McPc significantly improved skeletal muscle strength, motor coordination, and traction force in mice subjected to sciatic neurectomy and high-fat diet (HFD). McPc administration exhibited more pronounced improvement of obesity, hyperglycemia, fatty liver, and hyperlipidemia in HFD mice compared to control group. These findings support the notion that emodin and resveratrol-enriched McPc may offer health benefits for addressing skeletal muscle weakness. Full article
(This article belongs to the Special Issue Preventive and Therapeutic Nutraceuticals)
Show Figures

Figure 1

19 pages, 4892 KiB  
Article
Protective Role of Phenolic Compounds from Whole Cardamom (Elettaria cardamomum (L.) Maton) against LPS-Induced Inflammation in Colon and Macrophage Cells
by Shareena Sreedharan, Vimal Nair and Luis Cisneros-Zevallos
Nutrients 2023, 15(13), 2965; https://doi.org/10.3390/nu15132965 - 29 Jun 2023
Viewed by 2309
Abstract
The chemical profiling of phenolic and terpenoid compounds in whole cardamom, skin, and seeds (Elettaria cardamomum (L.) Maton) showed 11 phenolics and 16 terpenoids, many of which are reported for the first time. Herein, we report the anti-inflammatory properties of a methanolic [...] Read more.
The chemical profiling of phenolic and terpenoid compounds in whole cardamom, skin, and seeds (Elettaria cardamomum (L.) Maton) showed 11 phenolics and 16 terpenoids, many of which are reported for the first time. Herein, we report the anti-inflammatory properties of a methanolic extract of whole cardamom in colon and macrophage cells stimulated with an inflammatory bacteria lipopolysaccharide (LPS). The results show that cardamom extracts lowered the expression of pro-inflammatory genes NFkβ, TNFα, IL-6, and COX2 in colon cells by reducing reactive oxygen species (ROS) while not affecting LXRα. In macrophages, cardamom extracts lowered the expression of pro-inflammatory genes NFkβ, TNFα, IL-6, and COX2 and decreased NO levels through a reduction in ROS and enhanced gene expression of nuclear receptors LXRα and PPARγ. The cardamom extracts in a range of 200–800 μg/mL did not show toxicity effects in colon or macrophage cells. The whole-cardamom methanolic extracts contained high levels of phenolics compounds (e.g., protocatechuic acid, caffeic acid, syringic acid, and 5-O-caffeoylquinic acid, among others) and are likely responsible for the anti-inflammatory and multifunctional effects observed in this study. The generated information suggests that cardamom may play a protective role against low-grade inflammation that can be the basis of future in vivo studies using mice models of inflammation and associated chronic diseases. Full article
(This article belongs to the Special Issue Preventive and Therapeutic Nutraceuticals)
Show Figures

Graphical abstract

Review

Jump to: Research

23 pages, 6439 KiB  
Review
Exploring the Ecological Implications, Gastronomic Applications, and Nutritional and Therapeutic Potential of Juglans regia L. (Green Walnut): A Comprehensive Review
by Shaikh Ayaz Mukarram, Sangram S. Wandhekar, Abdelhakam Esmaeil Mohamed Ahmed, Vinay Kumar Pandey, Oláh Csaba, Daróczi Lajos, Prokisch József, Endre Harsányi and Kovács Bela
Nutrients 2024, 16(8), 1183; https://doi.org/10.3390/nu16081183 - 16 Apr 2024
Viewed by 1549
Abstract
The green walnut, which is frequently overlooked in favor of its more mature sibling, is becoming a topic of great significance because of its unique ecological role, culinary flexibility, and therapeutic richness. The investigation of the bioactive substances found in green walnuts and [...] Read more.
The green walnut, which is frequently overlooked in favor of its more mature sibling, is becoming a topic of great significance because of its unique ecological role, culinary flexibility, and therapeutic richness. The investigation of the bioactive substances found in green walnuts and their possible effects on human health has therapeutic potential. Juglans regia L. is an important ecological component that affects soil health, biodiversity, and the overall ecological dynamic in habitats. Comprehending and recording these consequences are essential for environmental management and sustainable land-use strategies. Regarding cuisine, while black walnuts are frequently the main attraction, green walnuts have distinct tastes and textures that are used in a variety of dishes. Culinary innovation and the preservation of cultural food heritage depend on the understanding and exploration of these gastronomic characteristics. Omega-3 fatty acids, antioxidants, vitamins, and minerals are abundant in green walnuts, which have a comprehensive nutritional profile. Walnuts possess a wide range of pharmacological properties, including antioxidant, antibacterial, antiviral, anticancer, anti-inflammatory, and cognitive-function-enhancing properties. Consuming green walnuts as part of one’s diet helps with antioxidant defense, cardiovascular health, and general well-being. Juglans regia L., with its distinctive flavor and texture combination, is not only a delicious food but also supports sustainable nutrition practices. This review explores the nutritional and pharmacological properties of green walnuts, which can be further used for studies in various food and pharmaceutical applications. Full article
(This article belongs to the Special Issue Preventive and Therapeutic Nutraceuticals)
Show Figures

Graphical abstract

Back to TopTop