Featured Articles on Nutrition and Obesity Management (2nd Edition)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 1186

Special Issue Editor

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Guest Editor
Metabolic Research Lab, Clínica Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain
Interests: obesity; dietary treatment; lifestyle intervention; pharmacological treatment; metabolic surgery; intermittent fasting; cardiometabolic risk improvement; body composition changes
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Special Issue Information

Dear Colleagues,

Obesity has become one of the most prevalent metabolic disorders. Excess adiposity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D), cardiovascular disease, dyslipidemia, fatty liver and cancer. In recent years, our understanding of the pathophysiology of obesity has greatly improved, and novel approaches for its treatment have emerged. However, the obesity pandemic continues without signs of abatement.

In this Special Issue, “Featured Articles on Nutrition and Obesity Management (2nd Edition)”, we welcome reviews and original articles related to any aspect of obesity management, from the traditional dietary approach (with different types of diets) to bariatric surgery, including pharmacologic treatments, with particular emphasis on recent successful combinations of drugs. We will also consider manuscripts regarding lifestyle modifications in relation to physical activity and sleep hygiene. Novel approaches such as the different modalities of intermittent fasting, including aspects relative to their effectiveness or the different physiological mechanisms involved, or the use of innovative technologies such as mobile apps or wearable devices, are very welcome. We aim to provide readers with a clear view of the pathophysiological relevance of weight loss and the improvements in cardiometabolic risk factors that occur with different therapeutic approaches, as well as the changes in body physiology and energy expenditure that drive weight regain. Original articles and reviews analyzing the clinical usefulness of predictors of treatment success and the importance of monitoring body composition in the management of patients living with obesity are also welcome.

Dr. Javier Gómez-Ambrosi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • obesity
  • dietary treatment
  • lifestyle intervention
  • pharmacological treatment
  • metabolic surgery
  • intermittent fasting
  • cardiometabolic risk improvement
  • body composition changes
  • weight regain
  • predictors of treatment success
  • use of wearable devices and apps for weight loss and weight maintenance
  • novel targets
  • treatment of children and adolescents

Published Papers (1 paper)

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13 pages, 3130 KiB  
A Combination of a Dopamine Receptor 2 Agonist and a Kappa Opioid Receptor Antagonist Synergistically Reduces Weight in Diet-Induced Obese Rodents
by Beatriz Cicuéndez, Javier Pérez-García and Cintia Folgueira
Nutrients 2024, 16(3), 424; https://doi.org/10.3390/nu16030424 - 31 Jan 2024
Viewed by 973
As the global obesity rate increases, so does the urgency to find effective anti-obesity drugs. In the search for therapeutic targets, central nervous system (CNS) mechanisms engaged in the regulation of energy expenditure and food intake, such as the opioid and dopamine systems, [...] Read more.
As the global obesity rate increases, so does the urgency to find effective anti-obesity drugs. In the search for therapeutic targets, central nervous system (CNS) mechanisms engaged in the regulation of energy expenditure and food intake, such as the opioid and dopamine systems, are crucial. In this study, we examined the effect on body weight of two drugs: bromocriptine (BC), a D2R receptor agonist, and PF-04455242, a selective κ opioid receptor (KOR) antagonist. Using diet-induced obese (DIO) rats, we aimed to ascertain whether the administration of BC and PF-04455242, independently or in combination, could enhance body weight loss. Furthermore, the present work demonstrates that the peripheral coadministration of BC and PF-04455242 enhances the reduction of weight in DIO rats and leads to a decrease in adiposity in a food-intake-independent manner. These effects were based on heightened energy expenditure, particularly through the activation of brown adipose tissue (BAT) thermogenesis. Overall, our findings indicate that the combination of BC and PF-04455242 effectively induces body weight loss through increased energy expenditure by increasing thermogenic activity and highlight the importance of the combined use of drugs to combat obesity. Full article
(This article belongs to the Special Issue Featured Articles on Nutrition and Obesity Management (2nd Edition))
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