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Nutrients
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New Insights on Bioactive Compounds for the Prevention and Management...
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New Insights on Bioactive Compounds for the Prevention and Management of Metabolic Syndrome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (10 March 2023) | Viewed by 10260

Special Issue Editors

Dr. Francisca Isabel Bravo

E-Mail Website1 Website2
Guest Editor
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain
Interests: phitochemicals; bioactive peptides; bioactive compounds characterization; antihypertensive activity; molecular biology
Special Issues, Collections and Topics in MDPI journals
Dr. Enrique Calvo Manso

E-Mail Website
Guest Editor
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Univer-sitat Rovira i Virgili, 43007 Tarragona, Spain
Interests: phitochemicals; bioactive peptides; bioactive compounds characterization; antihypertensive activity; molecular biology
Dr. Diego Morales

E-Mail Website
Guest Editor
Department of Galenic Pharmacy and Food Technology, Universitad Complutense de Madrid, Madrid, Spain
Interests: bioactive compound extraction; metabolic syndrome; bioactive polysaccharides; phenolic compounds; biological rhythms; mushrooms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic syndrome is characterized by the coexistence of different diseases including hypertension, obesity, insulin resistance and atherogenic dyslipidemia. It has a high prevalence in our society, as it is suffered up to 25 % of adults and 19.2 % of children. However, the treatment of metabolic syndrome and its associated pathologies is still a medical challenge, considering the complexity of this multifactorial disease. Therefore, new compounds are searched in order to prevent or reduce this cluster of diseases. In this regard, food and agri-food by-products contain different compounds such as phenolic compounds, fatty acids or peptides with antihypertensive, anti-hyperglycemic, anti-hypercholesterolemic, antioxidant and anti-inflammatory effects and also they can produce body weight loss or prevent against body weight gain. Thus, these compounds are highly studied in the search of metabolic syndrome treatments.

The aim of this special issue is to collect original research manuscripts, meta-analysis and reviews dealing with the beneficial effect of bioactive compounds on metabolic syndrome and its associated diseases. We invite clinicians and researchers to submit relevant scientific work to this Special Issue. Original research manuscripts, both using human and animal models, focused on the search and evaluation of the functional properties of original or known products, extracts, and single molecules from plants, food and agri-food by-products, as well as diets will be considered. Moreover, the in vitro or in vivo studies to elucidate the involved mechanisms in the effects of different bioactive compounds will be also welcomed.

Dr. Francisca Bravo
Dr. Enrique Calvo Manso
Dr. Diego Morales
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antihyperglycemic
  • antihypertensive
  • antioxidants
  • bioactive peptides
  • cardiovascular diseases
  • hyper-tension
  • obesity
  • phenolic compounds
  • phytochemicals

Published Papers (4 papers)

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Research

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17 pages, 1221 KiB  
Article
In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices
by Ma. Josefina Ruiz de Azua, Álvaro Cruz-Carrión, Begoña Muguerza, Gerard Aragonès, Anna Arola-Arnal, María Paz Romero, Francisca Isabel Bravo and Manuel Suarez
Nutrients 2023, 15(1), 43; https://doi.org/10.3390/nu15010043 - 22 Dec 2022
Viewed by 2114
Abstract
Tomatoes are widely consumed worldwide at any time of the year. However, depending on the variety, they have a characteristic season. We evaluated the consequences metabolic of consumption of Ekstasis tomatoes from different geographical origin and in different seasons in Fischer 344 rats. [...] Read more.
Tomatoes are widely consumed worldwide at any time of the year. However, depending on the variety, they have a characteristic season. We evaluated the consequences metabolic of consumption of Ekstasis tomatoes from different geographical origin and in different seasons in Fischer 344 rats. The hepatic gene expression of key enzymes in lipid metabolism was also evaluated. Animals were classified in three photoperiods (L6, L12, and L18) and in three treatments (vehicle: VH; local tomato: LT; and non-local tomato: nLT). We measured serum metabolic parameters and the gene expression of liver enzymes related to lipid metabolism (Acc1, Cpt1a, Had, Fas1, Srebp-1c, Fatp5, Cd36). LT consumption in season decreased cardiovascular risk 1 and coefficient atherogenic by 1.81 (p = 0.031) and in L6 decreased TAG and glucose (p = 0.046; p = 0.024). The L18-LT animals had decreased total cholesterol (p = 0.029) and gene expression of Srebp1-c (p = 0.022) but increased expression of Acc1 (p = 0.032). The treatments significantly affected the expression of Acc1 and Fas1 in the liver and the levels of serum TAG and glucose. A significant effect of photoperiod on serum concentration of glucose, insulin, HOMA index, and on the hepatic expression of Srep1-c, Fas1, and Acc1 was observed. Full article
(This article belongs to the Special Issue New Insights on Bioactive Compounds for the Prevention and Management of Metabolic Syndrome)
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14 pages, 2147 KiB  
Article
Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study
by Blanca Riquelme-Gallego, Laura García-Molina, Naomi Cano-Ibáñez, Francisco Andújar-Vera, Sheila González-Salvatierra, Cristina García-Fontana, Aurora Bueno-Cavanillas, Manuel Muñoz-Torres and Beatriz García-Fontana
Nutrients 2022, 14(14), 2991; https://doi.org/10.3390/nu14142991 - 21 Jul 2022
Cited by 2 | Viewed by 1998
Abstract
Lifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the cardiovascular risk (CVR) [...] Read more.
Lifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the cardiovascular risk (CVR) in the MetS population. In recent years, numerous biomarkers of bone metabolism have been associated with CVR. The aim of this study was to determine the levels of undercarboxylated osteocalcin (ucOC) in a cohort of patients with MetS and to analyse its association with MetS parameters and CVR as well as with T2D prevalence. A longitudinal study was conducted in which a MetS population was followed for one year. Weight change, adherence to the Mediterranean diet (MedDiet), ucOC levels, MetS parameters and CVR were analysed and CVR was calculated using different scores. Our results showed a decrease of CVR associated with a better adherence to the MetDiet resulting in higher HDL-C and ucOC levels though the improvement of MetS risk factors. This bone protein appeared as a potential biomarker to classify CVR in the MetS population, especially for MetS patients without prevalent T2D. Furthermore, ucOC serum levels could be good predictors of T2D prevalence. Full article
(This article belongs to the Special Issue New Insights on Bioactive Compounds for the Prevention and Management of Metabolic Syndrome)
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Review

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24 pages, 426 KiB  
Review
Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides
by Francisca Isabel Bravo, Enrique Calvo, Rafael A. López-Villalba, Cristina Torres-Fuentes, Begoña Muguerza, Almudena García-Ruiz and Diego Morales
Nutrients 2023, 15(2), 457; https://doi.org/10.3390/nu15020457 - 15 Jan 2023
Cited by 6 | Viewed by 2925
Abstract
Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of [...] Read more.
Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of increasing interest. Thus, agri-food industry byproducts have emerged as a valuable source to obtain these hydrolysates as they are rich in proteins and inexpensive. Among these, byproducts from animal origin stand out as they are abundantly generated worldwide. Hence, this review is focused on evaluating the potential role of chicken slaughterhouse byproducts as a source of peptides for managing HTN. Several of these byproducts such as blood, bones, skins, and especially, chicken feet have been used to obtain protein hydrolysates with angiotensin-converting enzyme (ACE)-inhibitory activity and blood pressure-lowering effects. An increase in levels of endogenous antioxidant compounds, a reduction in ACE activity, and an improvement of HTN-associated endothelial dysfunction were the mechanisms underlying their effects. However, most of these studies were carried out in animal models, and further clinical studies are needed in order to confirm these antihypertensive properties. This would increase the value of these byproducts, contributing to the circular economy model of slaughterhouses. Full article
(This article belongs to the Special Issue New Insights on Bioactive Compounds for the Prevention and Management of Metabolic Syndrome)
17 pages, 374 KiB  
Review
Potential Role of Bioactive Proteins and Peptides Derived from Legumes towards Metabolic Syndrome
by Marta Garcés-Rimón, Diego Morales and Marta Miguel-Castro
Nutrients 2022, 14(24), 5271; https://doi.org/10.3390/nu14245271 - 10 Dec 2022
Cited by 8 | Viewed by 2495
Abstract
Legumes have been widely consumed and used to isolate bioactive compounds, mainly proteins. The aim of this study was to review the beneficial actions of different legumes proteins and peptides updating the main findings that correlate legumes consumption and the effects on non-transmissible [...] Read more.
Legumes have been widely consumed and used to isolate bioactive compounds, mainly proteins. The aim of this study was to review the beneficial actions of different legumes proteins and peptides updating the main findings that correlate legumes consumption and the effects on non-transmissible chronic diseases, specifically metabolic syndrome. An exhaustive revision of five relevant bioactivities (antioxidant, anti-inflammatory, antihypertensive, hypocholesterolemic -all of them linked to metabolic syndrome- and antitumoral) of proteins and peptides from legumes focused on isolation and purification, enzymatic hydrolysis and in vitro gastrointestinal digestion was carried out. The promising potential of bioactive hydrolysates and peptides from pulses has been demonstrated by in vitro tests. However, only a few studies validated these biological activities using animal models. No clinical trials have been carried out yet; so further research is required to elucidate their effective health implications. Full article
(This article belongs to the Special Issue New Insights on Bioactive Compounds for the Prevention and Management of Metabolic Syndrome)
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