Fructose Metabolism and Diabetes – Where Do We Stand Now?
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Diabetes".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 4555
Special Issue Editor
2. Food and Nutrition Service Department, Fujita Health University Hospital, Toyoake 470-1192, Japan
Interests: sugar intake and obesity; malnutrition; vitamin deficiency; ultraprocessed food; artificial sweeteners; food recording apps
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Fructose is a monosaccharide with a higher protein glycolytic capacity than glucose that metabolizes faster than acetyl CoA due to the absence of rate-limiting enzymes such as glucokinase. It is also considered more toxic than glucose. Excessive sucrose intake is associated with obesity, hyperuricemia, type 2 diabetes, dyslipidemia, NAFLD, frailty, and cancer. Moreover, fructose has been thought to be metabolized in the liver, not in the small intestine. However, recent studies have shown that small amounts of fructose are completely converted to glucose, and its metabolites have been found in the small intestine. Furthermore, it has been shown that unabsorbed fructose is converted to acetic acid by intestinal bacteria, absorbed through the portal vein, and used for lipid synthesis. Therefore, when considering the mechanisms underlying fructose-induced fatty liver development, it is important to consider the role of the small intestine and even the intestinal microbiota in addition to the conventional liver. Furthermore, exogenous as well as endogenous fructose has been reported to cause renal damage.
For this Special Issue, we call for a wide range of original papers and review articles on the relationship between fructose intake and metabolic diseases, focusing on fructose metabolism in the gut, liver, gut microbiota, and kidneys.
Dr. Katsumi Iizuka
Guest Editor
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Keywords
- fructose
- gut microbiota
- fatty liver
- cancer
- kidney
- gut microbiota
- metabolic syndrome
- obesity
- diabetes mellitus
- dyslipidemia
