Nutrition in the Etiology, Prevention and Treatment of Malignant and Benign Digestive Disorders

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 1264

Special Issue Editors


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Guest Editor
President Scientific Council, Special Unit for Biomedical Research and Education, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: nutrition; gastroenterology; inflammatory bowel disease; hepatology; cancer epidemiology; experimental and translational research

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Guest Editor
Director IBD Unit, Metropolitan General Hospital, 15562 Holargos, Greece
Interests: nutrition; inflammatory bowel disease; malabsorption syndromes; chronic diarrhea; small and large bowel disorders; cancer epidemiology
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Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the role of diet, eating habits and specific nutritional elements in the epidemiology, etiology, prevention and treatment of malignant diseases (e.g., esophageal, stomach, colorectal, pancreatic and liver cancer) as well as in a group of important benign diseases of the digestive system (e.g., gastroesophageal reflux syndrome, irritable bowel syndrome and inflammatory bowel disease).

It is generally accepted that diet represents one of the most significant environmental factors in the etiology and treatment of a number of malignant and benign digestive disorders. Currently, well-documented dietary recommendations for the prevention of gastrointestinal cancer include a reduction in the intake of energy, fat, processed foods and alcohol and an increase in the consumption of fruits, vegetables and fiber. On the other hand, diet plays a significant role in the prevention and relief of patients’ symptoms in a number of benign digestive disorders, including diseases such as inflammatory bowel disease, which affect a large part of the world’s population.

It is also well accepted that the composition and function of the gut microbiome is continuously modulated under the influence of diet, which is considered to be one of the most powerful factors affecting it. Dietary factors in early life appear to substantially determine the risk of various diseases in later life. Pre- and probiotics could alter the diversity of the gut microbiome, which in turn influences colon carcinogenesis.

Bearing the aforementioned data in mind, we ask you to contribute to this Special Issue by submitting your latest research in this scientific field in the form of reviews, systematic reviews, or original articles.

Prof. Dr. Apostolos E. Papalois
Dr. John K. Triantafillidis
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • digestive cancer (esophageal, gastric, colorectal, pancreatic, and liver)
  • benign digestive disorders
  • diet
  • dietary components
  • dietary lipids
  • nutritional supplements and support
  • nutritional status
  • vitamins
  • antioxidants
  • Mediterranean diet and prevention
  • gut microbiota
  • immunity
  • exercise
  • alcohol
  • dietary fiber
  • pre- and probiotics
  • complementary and alternative medicine
  • nutritional support for the elderly
  • nutritional epidemiology
  • nutritional prevention
  • treatment and therapeutic responses
  • etiology
  • epidemiology

Published Papers (1 paper)

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Research

10 pages, 1259 KiB  
Article
Impact of Preoperative Nutritional Assessment on Other-Cause Survival after Gastrectomy in Patients with Gastric Cancer
by Ryota Matsui, Noriyuki Inaki and Toshikatsu Tsuji
Nutrients 2023, 15(14), 3182; https://doi.org/10.3390/nu15143182 - 18 Jul 2023
Cited by 1 | Viewed by 1101
Abstract
This study aimed to clarify the factors associated with death due to other diseases after a gastrectomy for gastric cancer. This retrospective cohort study included consecutive patients who had undergone gastrectomy between April 2008 and June 2018 for primary stage II–III gastric cancer. [...] Read more.
This study aimed to clarify the factors associated with death due to other diseases after a gastrectomy for gastric cancer. This retrospective cohort study included consecutive patients who had undergone gastrectomy between April 2008 and June 2018 for primary stage II–III gastric cancer. The primary outcome was other-cause survival. To identify prognostic factors for other-cause survival for univariate analysis, we used a Cox proportional hazard regression model. A total of 512 patients met the inclusion criteria. The average age was 67.93 years, and the average body mass index was 22.75 kg/m2, with 84 (16.4%) being moderately malnourished and 88 (17.2%) being severely malnourished, as defined by the Global Leadership Initiative on Malnutrition (GLIM) criteria. The other-cause survival for the malnourished group was significantly worse than that for the normal group (p < 0.001). The prognosis was worse when the severity of malnutrition was worse (p < 0.001). Multivariate analysis showed that severe malnutrition was significantly independent of prognostic factors for other-cause survival (hazard ratio: 3.310; 95% confidence interval: 1.426–7.682; p = 0.005). Undernutrition, as defined by the GLIM criteria, is useful for the preoperative prediction of death due to other diseases after gastrectomy in patients with advanced gastric cancer. Full article
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