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Biomedicines
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Microbiome in Inflammatory Bowel Disease (IBD)
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Microbiome in Inflammatory Bowel Disease (IBD)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 7311

Special Issue Editors

Dr. John K. Triantafillidis

E-Mail Website
Guest Editor
Director IBD Unit, Metropolitan General Hospital, 15562 Holargos, Greece
Interests: nutrition; inflammatory bowel disease; malabsorption syndromes; chronic diarrhea; small and large bowel disorders; cancer epidemiology
Special Issues, Collections and Topics in MDPI journals
Dr. Ferenc Sipos

E-Mail Website
Guest Editor
Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary
Interests: innate immunity; TLR9-signaling; autophagy; inflammation and cancer; inflammatory bowel disease; colorectal cancer; mucosal regeneration; immunology; gastroenterology; internal medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is well known that the incidence of inflammatory bowel disease (IBD) is increasing significantly in developing countries, while in others, it has now reached a plateau. This increase is largely related to environmental factors which in turn affect the human intestinal microbiome. The resulting dysbiosis increases the growth of opportunistic pathogens in the intestinal lumen, resulting in abnormal immune responses, thus promoting the onset of IBD. The purpose of this Special Issue is to define the role of the gut microbiome in the pathogenesis of IBD so that a more personalized therapeutic approach through exogenous modification of the gut microbiome could be possible shortly. An attempt will also be made to indicate the microorganisms that may participate in the disease pathogenesis, as well as the current therapeutic position of fecal transplantation, the relationship of nutritional interventions in IBD, and their effect on the composition of the intestinal microbiome.

We cordially invite authors to submit original research and review articles focusing on this important and rapidly expanding field of biomedicine. Potential topics include but are not limited to:

  • Gut microbiome, dysbiosis, and pathogenesis of IBD;
  • Probiotics and gut microbiome;
  • Fecal transplantation in the treatment of IBD;
  • Potential link between gut microbiome, COVID-19, and outcome of IBD;
  • Extraintestinal manifestations of IBD: Is there any link with the gut microbiome?
  • Intestinal yersiniosis, probiotics, and gut microbiome;
  • Autophagy, gut microbiome, and IBD;
  • Inflammasomes, IBD, and gut microbiome;
  • Nutritional aspects and gut microbiome in IBD: the role of the Mediterranean diet;
  • Vitamin D and intestinal homeostasis: the role of gut microbiome.

Prof. Dr. John K. Triantafillidis
Dr. Ferenc Sipos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease
  • ulcerative colitis
  • Crohn’s disease
  • gut microbiome
  • pathogenesis of IBD
  • nutrition
  • probiotics
  • COVID-19
  • fecal transplantation
  • intestinal yersiniosis

Published Papers (3 papers)

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Research

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19 pages, 3995 KiB  
Article
A Novel TLR4-SYK Interaction Axis Plays an Essential Role in the Innate Immunity Response in Bovine Mammary Epithelial Cells
by Fan Yang, Lu Yuan, Minghui Xiang, Qiang Jiang, Manling Zhang, Fanghui Chen, Jie Tong, Jinming Huang and Yafei Cai
Biomedicines 2023, 11(1), 97; https://doi.org/10.3390/biomedicines11010097 - 30 Dec 2022
Cited by 2 | Viewed by 1538
Abstract
Mammary gland epithelium, as the first line of defense for bovine mammary gland immunity, is crucial in the process of mammary glands’ innate immunity, especially that of bovine mammary epithelial cells (bMECs). Our previous studies successfully marked SYK as an important candidate gene [...] Read more.
Mammary gland epithelium, as the first line of defense for bovine mammary gland immunity, is crucial in the process of mammary glands’ innate immunity, especially that of bovine mammary epithelial cells (bMECs). Our previous studies successfully marked SYK as an important candidate gene for mastitis traits via GWAS and preliminarily confirmed that SYK expression is down-regulated in bMECs with LPS (E. coli) stimulation, but its work mechanism is still unclear. In this study, for the first time, in vivo, TLR4 and SYK were colocalized and had a high correlation in mastitis mammary epithelium; protein–protein interaction results also confirmed that there was a direct interaction between them in mastitis tissue, suggesting that SYK participates in the immune regulation of the TLR4 cascade for bovine mastitis. In vitro, TLR4 also interacts with SYK in LPS (E. coli)-stimulated or GBS (S. agalactiae)-infected bMECs, respectively. Moreover, TLR4 mRNA expression and protein levels were little affected in bMECsSYK- with LPS stimulation or GBS infection, indicating that SYK is an important downstream element of the TLR4 cascade in bMECs. Interestingly, IL-1β, IL-8, NF-κB and NLRP3 expression in LPS-stimulated or GBS-infected bMECsSYK- were significantly higher than in the control group, while AKT1 expression was down-regulated, implying that SYK could inhibit the IL-1β, IL-8, NF-κB and NLRP3 expression and alleviate inflammation in bMECs with LPS and GBS. Taken together, our solid evidence supports that TLR4/SYK/NF-κB signal axis in bMECs regulates the innate immunity response to LPS or GBS. Full article
(This article belongs to the Special Issue Microbiome in Inflammatory Bowel Disease (IBD))
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Review

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19 pages, 2177 KiB  
Review
The Role of the Microbiome in the Pathogenesis and Treatment of Ulcerative Colitis—A Literature Review
by Gabriela Świrkosz, Aleksandra Szczygieł, Katarzyna Logoń, Martyna Wrześniewska and Krzysztof Gomułka
Biomedicines 2023, 11(12), 3144; https://doi.org/10.3390/biomedicines11123144 - 25 Nov 2023
Cited by 2 | Viewed by 1876
Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the colon and rectum. UC’s pathogenesis involves colonic epithelial cell abnormalities and mucosal barrier dysfunction, leading to recurrent mucosal inflammation. The purpose of the article is to show the complex interplay between ulcerative [...] Read more.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the colon and rectum. UC’s pathogenesis involves colonic epithelial cell abnormalities and mucosal barrier dysfunction, leading to recurrent mucosal inflammation. The purpose of the article is to show the complex interplay between ulcerative colitis and the microbiome. The literature search was conducted using the PubMed database. After a screening process of studies published before October 2023, a total of 136 articles were selected. It has been discovered that there is a fundamental correlation of a robust intestinal microbiota and the preservation of gastrointestinal health. Dysbiosis poses a grave risk to the host organism. It renders the host susceptible to infections and has been linked to the pathogenesis of chronic diseases, with particular relevance to conditions such as ulcerative colitis. Current therapeutic strategies for UC involve medications such as aminosalicylic acids, glucocorticoids, and immunosuppressive agents, although recent breakthroughs in monoclonal antibody therapies have significantly improved UC treatment. Furthermore, modulating the gut microbiome with specific compounds and probiotics holds potential for inflammation reduction, while fecal microbiota transplantation shows promise for alleviating UC symptoms. This review provides an overview of the gut microbiome’s role in UC pathogenesis and treatment, emphasizing areas for further research. Full article
(This article belongs to the Special Issue Microbiome in Inflammatory Bowel Disease (IBD))
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14 pages, 1180 KiB  
Review
Colitis and Colorectal Carcinogenesis: The Focus on Isolated Lymphoid Follicles
by Györgyi Műzes, Bettina Bohusné Barta and Ferenc Sipos
Biomedicines 2022, 10(2), 226; https://doi.org/10.3390/biomedicines10020226 - 21 Jan 2022
Cited by 1 | Viewed by 3397
Abstract
Gut-associated lymphoid tissue is one of the most diverse and complex immune compartments in the human body. The subepithelial compartment of the gut consists of immune cells of innate and adaptive immunity, non-hematopoietic mesenchymal cells, and stem cells of different origins, and is [...] Read more.
Gut-associated lymphoid tissue is one of the most diverse and complex immune compartments in the human body. The subepithelial compartment of the gut consists of immune cells of innate and adaptive immunity, non-hematopoietic mesenchymal cells, and stem cells of different origins, and is organized into secondary (and even tertiary) lymphoid organs, such as Peyer’s patches, cryptopatches, and isolated lymphoid follicles. The function of isolated lymphoid follicles is multifaceted; they play a role in the development and regeneration of the large intestine and the maintenance of (immune) homeostasis. Isolated lymphoid follicles are also extensively associated with the epithelium and its conventional and non-conventional immune cells; hence, they can also function as a starting point or maintainer of pathological processes such as inflammatory bowel diseases or colorectal carcinogenesis. These relationships can significantly affect both physiological and pathological processes of the intestines. We aim to provide an overview of the latest knowledge of isolated lymphoid follicles in colonic inflammation and colorectal carcinogenesis. Further studies of these lymphoid organs will likely lead to an extended understanding of how immune responses are initiated and controlled within the large intestine, along with the possibility of creating novel mucosal vaccinations and ways to treat inflammatory bowel disease or colorectal cancer. Full article
(This article belongs to the Special Issue Microbiome in Inflammatory Bowel Disease (IBD))
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