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The Effect of the Mediterranean Diet on Metabolic Health (2nd Edition)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 3358

Special Issue Editors


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Guest Editor
International Center for the Assessment of Nutritional Status (ICANS), Department of Food Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
Interests: food consumption; dietary pattern; Mediterranean diet; body composition; obesity; metabolic syndrome; eating behavior; nutritional epidemiology; plant-based foods
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Guest Editor
International Center for the Assessment of Nutritional Status (ICANS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Sandro Botticelli 21, 20133 Milan, Italy
Interests: role of dietary therapies in management of obesity; eating disorders and rare diseas-es; the association between dietary patterns, eating be-havior, body composition and clinical outcomes in children and adults
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is much evidence to suggest that the Mediterranean diet could serve as an anti-inflammatory dietary model in many domains of human health across various ages, including components of metabolic syndromes and several metabolic risk factors.

However, the results should be interpreted with caution because of the heterogeneity among studies, and more high-quality studies are needed to provide robust evidence on the effect of the Mediterranean diet on the incidence of metabolic syndrome and its related comorbidities and the use of pharmacotherapy, as well as to delineate the biological mechanisms responsible for the global health benefits.

Therefore, the aim of this Special Issue is to obtain high-quality scientific evidence on the effect of the Mediterranean diet on the management of metabolic health, which has become even more of a priority after the COVID-19 pandemic, even in children and adolescents. Original research articles and reviews focused on the intake, absorption, and metabolism of dietary components typical of the Mediterranean pattern that are useful in metabolic syndrome management are also welcome.

Dr. Alessandro Leone
Dr. Ramona Silvana De Amicis
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Mediterranean diet
  • metabolic syndrome
  • metabolic health
  • dyslipidemia
  • hypertension
  • impaired glycemic control
  • inflammation
  • adipose tissue
  • metabolic risk factors

Published Papers (1 paper)

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Review

18 pages, 1891 KiB  
Review
Does the Mediterranean Diet Have Any Effect on Lipid Profile, Central Obesity and Liver Enzymes in Non-Alcoholic Fatty Liver Disease (NAFLD) Subjects? A Systematic Review and Meta-Analysis of Randomized Control Trials
by Cristian Del Bo’, Simone Perna, Sabika Allehdan, Ayesha Rafique, Sara Saad, Fahad AlGhareeb, Mariangela Rondanelli, Reema F. Tayyem, Mirko Marino, Daniela Martini and Patrizia Riso
Nutrients 2023, 15(10), 2250; https://doi.org/10.3390/nu15102250 - 09 May 2023
Cited by 6 | Viewed by 3121
Abstract
The effectiveness of the Mediterranean diet (MD) in non-alcoholic fatty liver disease (NAFLD) subjects has been evaluated in several randomized controlled trials (RCTs). This systematic review and meta-analysis aimed to evaluate the overall effects of MD intervention in a cohort of NAFLD patients [...] Read more.
The effectiveness of the Mediterranean diet (MD) in non-alcoholic fatty liver disease (NAFLD) subjects has been evaluated in several randomized controlled trials (RCTs). This systematic review and meta-analysis aimed to evaluate the overall effects of MD intervention in a cohort of NAFLD patients targeting specific markers such as central obesity, lipid profile, liver enzymes and fibrosis, and intrahepatic fat (IHF). Google Scholar, PubMed, and Scopus were explored to collect relevant studies from the last 10 years. RCTs with NAFLD subjects were included in this systematic review with a mean intervention duration from 6 weeks to 1 year, and different intervention strategies, mainly including energy restriction MD (normal or low glycaemic index), low-fat MD with increased monounsaturated and polyunsaturated fatty acids, and increased exercise expenditure. The outcomes measured in this meta-analysis were gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), total cholesterol (TC), waist circumference (WC), and liver fibrosis. Ten randomized controlled trials, which involved a total of 737 adults with NAFLD, were included. According to the results, the MD seems to decrease the liver stiffness (kPa) by –0.42 (CI95% –0.92, 0.09) (p = 0.10) and significantly reduce the TC by –0.46 mg/dl (CI95% –0.55, −0.38) (p = 0.001), while no significant findings were documented for liver enzymes and WC among patients with NAFLD. In conclusion, the MD might reduce indirect and direct outcomes linked with NAFLD severity, such as TC, liver fibrosis, and WC, although it is important to consider the variations across trials. Further RCTs are necessary to corroborate the findings obtained and provide further evidence on the role of the MD in the modulation of other disorders related to NAFLD. Full article
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