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Nutrients
Special Issues
Nutrition Support in Transplantation
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Nutrition Support in Transplantation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 5 May 2024 | Viewed by 2349

Special Issue Editors

Dr. Marie Sinclair

E-Mail Website
Guest Editor
Department of Medicine, The University of Melbourne, Parkville 3050, Australia
Interests: liver; transplant; sarcopenia; malnutrition
Dr. Ken Liu

E-Mail Website
Co-Guest Editor
Australian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia
Interests: liver; transplantation; care; dietary supplements

Special Issue Information

Dear Colleagues,

Malnutrition and muscle wasting are increasingly well-recognised risk factors for poor outcomes peri-operatively, and transplantation is no exception.  Chronic liver disease and end-stage renal failure are clearly associated with malnutrition with complex multifaceted physiological changes contributing to their development. Despite clear associations described between malnutrition and adverse clinical outcomes before and after transplantation, and multiple society guidelines providing recommendations in this space, there are still very few evidence-based strategies to target malnutrition in these cohorts.

This Special Edition will include manuscripts that focus on interventions that target malnutrition and sarcopenia in patients waitlisted for or undergoing solid organ transplantation. This collection is the result of international scientific cooperation of experts specializing in these issues. The content may be useful for clinical practitioners and inspire further innovative research.

Dr. Marie Sinclair
Dr. Ken Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • malnutrition
  • sarcopenia
  • transplantation

Published Papers (2 papers)

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Research

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14 pages, 674 KiB  
Article
Association of Three Different Dietary Approaches to Stop Hypertension Diet Indices with Renal Function in Renal Transplant Recipients
by I-Hsin Lin, Tuyen Van Duong, Yi-Chun Chen, Shih-Wei Nien, I-Hsin Tseng, Yi-Ming Wu, Yang-Jen Chiang, Hsu-Han Wang, Chia-Yu Chiang, Chia-Hui Chiu, Ming-Hsu Wang, Chia-Tzu Chang, Nien-Chieh Yang, Ying-Tsen Lin and Te-Chih Wong
Nutrients 2023, 15(18), 3958; https://doi.org/10.3390/nu15183958 - 13 Sep 2023
Cited by 1 | Viewed by 974
Abstract
Several dietary indices assess the impacts of the Dietary Approaches to Stop Hypertension (DASH) diet on health outcomes. We explored DASH adherence and renal function among 85 Taiwanese renal transplant recipients (RTRs) in a cross-sectional study. Data collection included demographics, routine laboratory data, [...] Read more.
Several dietary indices assess the impacts of the Dietary Approaches to Stop Hypertension (DASH) diet on health outcomes. We explored DASH adherence and renal function among 85 Taiwanese renal transplant recipients (RTRs) in a cross-sectional study. Data collection included demographics, routine laboratory data, and 3-day dietary records. Three separate DASH indices, that defined by Camões (based on nine nutrients), that defined by Fung (using seven food groups and sodium), and that modified by Fung (as above but separated for men and women) were used. Renal function was ascertained through the estimated glomerular filtration rate (eGFR) from patients’ medical records. Participants’ mean age was 49.7 ± 12.6 years and eGFR was 54.71 ± 21.48 mL/min/1.73 m2. The three established DASH diet indices displayed significant correlations (r = 0.50–0.91) and indicated the nutritional adequacy of the diet. Multiple linear regressions indicated a significant positive association between higher DASH scores for each index and increased eGFR. In addition, RTRs in the highest DASH score tertile had higher eGFR rates than those in the lowest tertile, regardless of confounding variables. Adherence to a DASH-style diet correlated with better renal function among RTRs. Educating RTRs about the DASH diet may prevent graft function deterioration. Full article
(This article belongs to the Special Issue Nutrition Support in Transplantation)
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Review

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21 pages, 1844 KiB  
Review
Portal Hypertension in Malnutrition and Sarcopenia in Decompensated Cirrhosis—Pathogenesis, Implications and Therapeutic Opportunities
by Ryma Terbah, Adam Testro, Paul Gow, Avik Majumdar and Marie Sinclair
Nutrients 2024, 16(1), 35; https://doi.org/10.3390/nu16010035 - 21 Dec 2023
Viewed by 1121
Abstract
Malnutrition and sarcopenia are highly prevalent in patients with decompensated cirrhosis and are associated with poorer clinical outcomes. Their pathophysiology is complex and multifactorial, with protein-calorie malnutrition, systemic inflammation, reduced glycogen stores and hormonal imbalances all well reported. The direct contribution of portal [...] Read more.
Malnutrition and sarcopenia are highly prevalent in patients with decompensated cirrhosis and are associated with poorer clinical outcomes. Their pathophysiology is complex and multifactorial, with protein-calorie malnutrition, systemic inflammation, reduced glycogen stores and hormonal imbalances all well reported. The direct contribution of portal hypertension to these driving factors is however not widely documented in the literature. This review details the specific mechanisms by which portal hypertension directly contributes to the development of malnutrition and sarcopenia in cirrhosis. We summarise the existing literature describing treatment strategies that specifically aim to reduce portal pressures and their impact on nutritional and muscle outcomes, which is particularly relevant to those with end-stage disease awaiting liver transplantation. Full article
(This article belongs to the Special Issue Nutrition Support in Transplantation)
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