Special Issue "Epithelial-Mesenchymal Transition"
Deadline for manuscript submissions: closed (20 November 2015) | Viewed by 254659
Interests: liver fibrosis; origin of hepatic myofibroblasts; EMT; hepatic stellate cells; NOX; treatment of liver fibrosis; reversibility of liver fibrosis
Interests: fibrocytes; EMT; hepatic stellate cells; portal fibroblasts; the role of IL-17 signaling in pathogenesis of liver fibrosis
Interests: epithelial–mesenchymal transition; TGFB; breast cancer; metastasis; inflammation
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The last decade has seen an explosion in studies that have examined the role of EMT in various contexts of physiology and disease. EMT has convincingly been proven to play an important role in the trans-differentiation of epithelial cells into mesenchymal cells during embryonic development. Also, despite of debates regarding the best methodology for tracing EMT, the data obtained from cancer patients and mouse models of different types of epithelial cancers suggest that epithelial cells may undergo EMT in response to a dynamically changing tumor microenvironment and obtain markers of mesenchymal cells. However, although several studies have utilized different models of fibrogenic injury in mice, and also immunocytochemistry-based analysis of adult human tissues has implicated EMT in the pathogenesis of liver fibrosis, this topic remains controversial. Here, we would like to reinitiate the discussion on the role of EMT in embryonic development, fibrosis, and cancer, and invite scientists whose intellectual contribution to this field is immense, and whose insightful opinions, acquired throughout years of superb research, may advance our understanding of this process.
Prof. Dr. David A. Brenner
Dr. Tatiana Kisseleva
Dr. Jonas Fuxe
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- epithelial cells