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Natural Bioactive Compounds with Antioxidant/Anticancer/Antiaging Proprieties in Foods for Promoting...
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Natural Bioactive Compounds with Antioxidant/Anticancer/Antiaging Proprieties in Foods for Promoting Animal and Human Health

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 6693

Special Issue Editors

Dr. Orsolina Petillo

E-Mail Website
Guest Editor
Consiglio Nazionale delle Ricerche, Rome, Italy
Interests: natural compounds; health; cellular biology; functional foods; nutraceuticals; antioxidant activity; cytoprotective activity
Dr. Nunzio Antonio Cacciola

E-Mail Website
Guest Editor
Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino, 1, 80137 Naples, Italy
Interests: phytotherapy; pharmacology; natural products; colorectal cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Filomena Anna Digilio

E-Mail Website
Guest Editor
Consiglio Nazionale delle Ricerche, Rome, Italy
Interests: drosophila melanogaster; aging; neurodegeneration; endocrine distruptors; bioactive molecules; nutraceuticals; pollution

Special Issue Information

Dear Colleagues,

Despite recent advances in the treatment of human and animal diseases (e.g., metabolic, infectious, neurodegenerative, and cardiovascular diseases, cancer), the occurrence of side effects, which can sometimes be quite severe, after long-term treatment with synthetic drugs encourages nutrition research to identify and characterize novel molecules with intrinsic pharmacological properties. In view of this, there is pressure in various sectors for the development of products that meet this demand, e.g., in the food industry and in healthcare. Considering that a large proportion of the drugs on the market are natural bioactive compounds and their synthetic derivatives, pharmacological research cannot ignore the identification of active molecules from this source. Bioactive compounds, such as polyphenols, carotenoids, chitosan, peptides, mono-polyunsaturated fatty acids, algae, and food waste, have excellent potential as functional food ingredients, since they have advantageous physiological effects and benefits for the health, as well as antioxidant, anticancer, or anti-aging activities. With this Special Issue, we aim to bridge the gap in different disciplines in accordance with the One Health perspective. We invite researchers to contribute to this Special Issue by submitting their most recent findings on potential applications of natural compounds, from food additives and supplement substances to their use in human and animal wellbeing. Original research papers and reviews are welcome.

Potential topics include but are not limited to the following:

  • Identification of natural products in food;
  • In vitro and in vivo evaluation natural compound activities;
  • Potential applications of natural compounds for human health;
  • Potential applications of natural compounds for animal health;
  • Discovery, identification, and evaluation of natural compounds from food waste.

Dr. Orsolina Petillo
Dr. Nunzio Antonio Cacciola
Dr. Filomena Anna Digilio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • health effects
  • microbiota modulation activity
  • functional foods
  • food profiling
  • plant extracts
  • food byproducts
  • phytocomplexes
  • food safety

Published Papers (3 papers)

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Research

14 pages, 1816 KiB  
Article
Effect of Yeast Fermentation on the Physicochemical Properties and Bioactivities of Polysaccharides of Dendrobium officinale
by Hang Chen, Xueqin Shi, Lanyan Cen, Lin Zhang, Yifeng Dai, Shuyi Qiu, Xiangyong Zeng and Chaoyang Wei
Foods 2023, 12(1), 150; https://doi.org/10.3390/foods12010150 - 28 Dec 2022
Cited by 5 | Viewed by 1848
Abstract
Fermentation is an effective method for enhancing the biological activity of polysaccharides, but research on its effect on Dendrobium officinal polysaccharides is rare. In this study, the effects of mono-fermentation (Saccharomyces cerevisiae FBKL2.8022, Sc; Wickerhamomyces anomalous FBKL2.8023, Wa) and co-fermentation [...] Read more.
Fermentation is an effective method for enhancing the biological activity of polysaccharides, but research on its effect on Dendrobium officinal polysaccharides is rare. In this study, the effects of mono-fermentation (Saccharomyces cerevisiae FBKL2.8022, Sc; Wickerhamomyces anomalous FBKL2.8023, Wa) and co-fermentation (Sc+Wa) on the physicochemical properties and bioactivity of Dendrobium officinal polysaccharides were investigated. Meanwhile, the polysaccharide (DOP) obtained from Dendrobium officinale was used as a control. Four homogeneous polysaccharides were obtained by isolation and purification and named DOSCP, DOWAP, DOSWP, and DOP. The results showed that DOSCP, DOWAP, DOSWP, and DOP consisted of mannose and glucose with ratios of 3.31:1, 5.56:1, 2.40:1, and 3.29:1, respectively. The molecular weights (Mws) of the four polysaccharides were 25.73 kDa, 15.01 kDa, 17.67 kDa, and 1268.21 kDa. The antioxidant activity of DOSCP, DOWAP, and DOSWP was better than that of DOP. Additionally, all four polysaccharides were able to reduce the inflammatory response of LPS-induced RAW 264.7 macrophages in the mice without a significant difference. Yeast fermentation significantly reduced the molecular weight and improved the antioxidant activity of Dendrobium officinale polysaccharides, indicating a potential way to improve its antioxidant activity. Full article
(This article belongs to the Special Issue Natural Bioactive Compounds with Antioxidant/Anticancer/Antiaging Proprieties in Foods for Promoting Animal and Human Health)
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21 pages, 2895 KiB  
Article
Inhibitory Effect of Dietary Defatted Rice Bran in an AOM/DSS-Induced Colitis-Associated Colorectal Cancer Experimental Animal Model
by Laleewan Tajasuwan, Aikkarach Kettawan, Thanaporn Rungruang, Kansuda Wunjuntuk, Pinidphon Prombutara, Chawanphat Muangnoi and Aurawan Kringkasemsee Kettawan
Foods 2022, 11(21), 3488; https://doi.org/10.3390/foods11213488 - 02 Nov 2022
Cited by 8 | Viewed by 2391
Abstract
Defatted rice bran (DRB) is gaining immense popularity worldwide because of its nutritional and functional aspects. Emerging evidence suggests that DRB is a potential source of dietary fiber and phenolic compounds with numerous purported health benefits. However, less is known about its chemoprotective [...] Read more.
Defatted rice bran (DRB) is gaining immense popularity worldwide because of its nutritional and functional aspects. Emerging evidence suggests that DRB is a potential source of dietary fiber and phenolic compounds with numerous purported health benefits. However, less is known about its chemoprotective efficacy. In the present study, we determined and examined the nutrient composition of DRB and its chemopreventive effect on azoxymethane and dextran sulphate sodium (AOM/DSS)-induced colitis-associated colorectal cancer (CRC) in rats. The results showed the presence of several bioactive compounds, such as dietary fiber, phytic acid, and phenolic acids, in DRB. In addition, DRB supplementation reduced the progression of CRC symptoms, such as colonic shortening, disease activity index (DAI), and histopathological changes. Interestingly, a significant decrease was observed in total numbers of aberrant crypt foci (ACFs) and tumors with DRB supplementation. Furthermore, DRB supplementation suppressed the expression of pro-inflammatory cytokines (IL-6) and inflammatory mediators (NF-κB and COX-2) through the inactivation of the NF-κB signaling pathway. The administration of DRB revealed a negative effect on cancer cell proliferation by repressing the expression of nuclear β-catenin, cyclin D1, and c-Myc. These findings suggest that DRB supplementation mitigates chronic inflammation and cancer cell proliferation and delays tumorigenesis in rat AOM/DSS-induced colitis-associated CRC. Therefore, the establishment of DRB as a natural dietary food-derived chemopreventive agent has the potential to have a significant impact on cancer prevention in the global population. Full article
(This article belongs to the Special Issue Natural Bioactive Compounds with Antioxidant/Anticancer/Antiaging Proprieties in Foods for Promoting Animal and Human Health)
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12 pages, 2174 KiB  
Article
Improving Effect of the Policosanol from Ericerus pela Wax on Learning and Memory Impairment Caused by Scopolamine in Mice
by Long Sun, Xian Li, Chenjing Ma, Zhao He, Xin Zhang, Chengye Wang, Min Zhao, Jin Gan and Ying Feng
Foods 2022, 11(14), 2095; https://doi.org/10.3390/foods11142095 - 14 Jul 2022
Cited by 9 | Viewed by 1647
Abstract
Policosanol (PC) is a mixture of long-chain fatty alcohols that exhibits multiple biological activities, such as reducing blood lipid and cholesterol levels, lowering blood pressure, and extenuating liver inflammation. To assess PC’s impact on cognitive behavior and function, PC was prepared from Ericerus [...] Read more.
Policosanol (PC) is a mixture of long-chain fatty alcohols that exhibits multiple biological activities, such as reducing blood lipid and cholesterol levels, lowering blood pressure, and extenuating liver inflammation. To assess PC’s impact on cognitive behavior and function, PC was prepared from Ericerus pela wax using a reduction method and analyzed using gas chromatography (GC). A total of 60 mice were randomly divided into six groups of 10 animals each: control (0.5% CMC-Na solution, i.g.), model (0.5% CMC-Na solution, i.g.), donepezil (3 mg/kg, i.g.), PC low- (2 g/kg, i.g.), medium (4 g/kg, i.g.), and high- (6 g/kg, i.g.) dose groups. All the groups were administered daily for 28 consecutive days. There were four parameters—escape latency, crossings of platform, swimming distance, and time spent in the target quadrant—that were recorded to evaluate the cognitive performance of mice in the Morris Water Maze (MWM). After MWM testing, the levels of acetylcholine (ACh), acetylcholinesterase (AChE), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) that were present in brain tissue were determined using assay kits. The GC data showed that PC consisted of four major components: tetracosanol (14.40%), hexacosanol (48.97%), octacosanol (25.40%), and triacontanol (4.80%). In the MWM test, PC significantly decreased the escape latency (p < 0.05) and increased the crossings of the platform (p < 0.05) and swimming distance (p < 0.05) and time in the target quadrant (p < 0.05) in rodents compared to that in the model group. Moreover, PC increased the levels of ACh, SOD, and GSH; inhibited AChE; and reduced MDA in the brain tissue of the tested animals. This is the first report to evaluate the efficacy of PC for cognitive behavior and function in animals. Our findings demonstrate that PC from E. pela wax is likely to exert an enhancing effect on learning and memory by promoting the cholinergic system and attenuating oxidative stress, which will provide a new insight into the efficacy of PC and expand its application in the food, nutraceutical, and beverage industries. Full article
(This article belongs to the Special Issue Natural Bioactive Compounds with Antioxidant/Anticancer/Antiaging Proprieties in Foods for Promoting Animal and Human Health)
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