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Dietary Bioactive Compounds: Implications for Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 May 2024) | Viewed by 1409

Special Issue Editors


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Guest Editor

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Guest Editor
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy
Interests: phytotherapy; natural products; colorectal cancer; inflammatory bowel diseases

E-Mail Website
Guest Editor
Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy
Interests: phytotherapy; natural products; skin cancer; inflammatory bowel diseases

Special Issue Information

Dear Colleagues,

There is strong scientific evidence that regular consumption of fruits and vegetables is associated with a lower risk of chronic diseases such as cardiovascular disease, cancer, diabetes, Alzheimer's disease, and age-related functional decline. Plant foods contain bioactive compounds such as flavonoids, carotenoids, lipids, vitamins, minerals, and fiber that have been shown to be responsible for biological activities. For some bioactive compounds, modern methods of cellular and molecular biology have made it possible to understand the mechanisms of action that underline their effects.

This Special Issue aims to provide a contemporary understanding of dietary plant extracts and their bioactive compounds in human nutrition and health, particularly the underlying cellular and molecular mechanisms of action of these bioactive dietary constituents. We invite the submission of short communications, original articles, and reviews that highlight the history and advance our current knowledge of bioactive dietary constituents in human health.

Dr. Nunzio Antonio Cacciola
Prof. Dr. Francesca Borrelli
Dr. Paola De Cicco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary bioactive compounds
  • bioactive constituents
  • health effects
  • epidemiology
  • cancer
  • neurodegeneration
  • chronic inflammation

Published Papers (1 paper)

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Research

22 pages, 5668 KiB  
Article
Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis
by Zhong-Hao Ji, Wen-Yin Xie, Pei-Sen Zhao, Hong-Yu Wu, Wen-Zhi Ren, Jin-Ping Hu, Wei Gao and Bao Yuan
Nutrients 2023, 15(24), 5055; https://doi.org/10.3390/nu15245055 - 9 Dec 2023
Cited by 2 | Viewed by 1111
Abstract
The prevalence of inflammatory bowel disease (IBD) is progressively rising each year, emphasizing the significance of implementing rational dietary interventions for disease prevention. Oats, being a staple agricultural product, are abundant in protein content. This study aimed to investigate the protective effects and [...] Read more.
The prevalence of inflammatory bowel disease (IBD) is progressively rising each year, emphasizing the significance of implementing rational dietary interventions for disease prevention. Oats, being a staple agricultural product, are abundant in protein content. This study aimed to investigate the protective effects and underlying mechanisms of oat peptides (OPs) in a mouse model of acute colitis induced by dextran sulfate sodium salt (DSS) and a Caco-2 cell model. The findings demonstrated that intervention with OPs effectively mitigated the symptoms associated with DSS-induced colitis. The physicochemical characterization analysis demonstrated that the molecular weight of the OPs was predominantly below 5 kDa, with a predominant composition of 266 peptides. This study provides further evidence of the regulatory impact of OPs on the Keap1-Nrf2 signaling axis and elucidates the potential role of WGVGVRAERDA as the primary bioactive peptide responsible for the functional effects of OPs. Ultimately, the results of this investigation demonstrate that OPs effectively mitigate DSS-induced colitis by preserving the integrity of the intestinal barrier and modulating the Keap1-Nrf2 axis. Consequently, these findings establish a theoretical foundation for the utilization of OPs as dietary supplements to prevent the onset of IBD. Full article
(This article belongs to the Special Issue Dietary Bioactive Compounds: Implications for Health and Disease)
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