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Special Issue "Application of Translational Mathematical Modeling in Drug Development"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (31 January 2019) | Viewed by 73982
Special Issue Editors
Interests: pharmacokinetics; translational PKPD modeling; PBPK modeling; in vitro–in vivo correlation; pharmaceutical analysis; 3D printing
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Interests: anti-infective drug discovery; drug development; antimicrobials; combination therapy; optimal patient therapies; pharmacokinetics; pharmacodynamics; translational pharmacology; population pharmacokinetic / pharmacodynamic modeling; target site penetration; bacterial infections; multidrug-resistant Gram-negative bacteria; Acinetobacter baumannii; Pseudomonas aeruginosa; Klebsiella pneumoniae; cell wall synthesis; in vitro infection models
Special Issue Information
Despite great advances in biomedical science and technology, as well as increasing research and development spending, the success rates in drug development remain low with a declining trend. Translational, model-based drug development can improve the rigor and efficiency of drug development by employing pharmacokinetic and pharmacodynamic principles to describe and predict drug behavior. This allows us to better understand mechanisms and exploit them for drug development. Modelling and simulations presents a powerful approach to integrate information from different stages of drug development and support decision making. In turn, this enables the design of more informative studies, saving cost and time, and ultimately enhance the success rates of drug development. Model-based drug development is a paradigm that covers the whole spectrum of the drug development process.
This Special Issue is intended to cover a broad range of topics in translational mathematical modelling applied to drug development. This includes, but is not limited to, pharmacokinetic/pharmacodynamic (PK/PD) models, physiologically-based pharmacokinetic (PBPK) models, population models, in vitro-in vivo correlations (IVIVC), and systems pharmacology approaches. We seek to highlight recent advances and innovations in this area and invite the researchers and drug developers to contribute their original research work or review articles.
Prof. Beom Soo Shin
Prof. Jürgen B. Bulitta
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Modeling and simulation
- Physiologically based pharmacokinetic modeling
- Population modeling
- Translational pharmacology
- Quantitative systems pharmacology
- In vitro-in vivo correlations
- Interspecies scaling