Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.9
5.4
Journals
Pharmaceutics
Special Issues
Novel Controlled Release Drug Delivery Systems by Applying 3D Printing...
share announcement

Novel Controlled Release Drug Delivery Systems by Applying 3D Printing Technology

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 3727

Special Issue Editors

Prof. Dr. Soyoung Shin

E-Mail
Guest Editor
College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea
Interests: pharmacokinetics; pharmacodynamics; modeling and simulation; 3D printing; controlled release formulations
Prof. Dr. Beom Soo Shin

E-Mail Website
Guest Editor
School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Republic of Korea
Interests: pharmacokinetics; translational PKPD modeling; PBPK modeling; in vitro–in vivo correlation; pharmaceutical analysis; 3D printing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Since the first FDA approval of 3D printed tablet, there has been an emerging interest in the pharmaceutical application of 3D printing technology, or additive manufacturing. The unique advantages of 3D printing technology over conventional manufacturing have shown its potential to improve upon current pharmaceutical dosage forms through complex and customized dosage forms which are not cost-effective or otherwise impossible. In the last decades, therefore, 3D printing has been extensively explored and applied to design and develop innovative controlled release dosage forms.

In this Special Issue, we seek to highlight the advantages, key challenges, and future directions of the application of 3D printing technology for the development of novel controlled release drug delivery systems. Topics may include, but are not limited to, various innovative applications of 3D printing technology in controlled release dosage forms and drug delivery systems and their in vitro as well as in vivo evaluations. We look forward to your submission of original research work or review articles.

Prof. Soyoung Shin
Prof. Beom Soo Shin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D printing
  • additive manufacturing
  • controlled release
  • oral dosage forms
  • drug delivery system
  • sustained release
  • gastroretentive system
  • in vitro test
  • in vivo pharmacokinetics

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

22 pages, 19554 KiB  
Article
Three-Dimensional Printing of Curcumin-Loaded Biodegradable and Flexible Scaffold for Intracranial Therapy of Glioblastoma Multiforme
by Ruixiu Li, Yunmei Song, Paris Fouladian, Mohammad Arafat, Rosa Chung, Jarrod Kohlhagen and Sanjay Garg
Pharmaceutics 2021, 13(4), 471; https://doi.org/10.3390/pharmaceutics13040471 - 31 Mar 2021
Cited by 19 | Viewed by 2987
Abstract
A novel drug delivery system preventing Glioblastoma multiforme (GBM) recurrence after resection surgery is imperatively required to overcome the mechanical limitation of the current local drug delivery system and to offer personalised treatment options for GBM patients. In this study, 3D printed biodegradable [...] Read more.
A novel drug delivery system preventing Glioblastoma multiforme (GBM) recurrence after resection surgery is imperatively required to overcome the mechanical limitation of the current local drug delivery system and to offer personalised treatment options for GBM patients. In this study, 3D printed biodegradable flexible porous scaffolds were developed via Fused Deposition Modelling (FDM) three-dimensional (3D) printing technology for the local delivery of curcumin. The flexible porous scaffolds were 3D printed with various geometries containing 1, 3, 5, and 7% (w/w) of curcumin, respectively, using curcumin-loaded polycaprolactone (PCL) filaments. The scaffolds were characterised by a series of characterisation studies and in vitro studies were also performed including drug release study, scaffold degradation study, and cytotoxicity study. The curcumin-loaded PCL scaffolds displayed versatile spatiotemporal characteristics. The polymeric scaffolds obtained great mechanical flexibility with a low tensile modulus of less than 2 MPa, and 4 to 7-fold ultimate tensile strain, which can avoid the mechanical mismatch problem of commercially available GLIADEL wafer with a further improvement in surgical margin coverage. In vitro release profiles have demonstrated the sustained release patterns of curcumin with adjustable release amounts and durations up to 77 h. MTT study has demonstrated the great cytotoxic effect of curcumin-loaded scaffolds against the U87 human GBM cell line. Therefore, 3D printed curcumin-loaded scaffold has great promise to provide better GBM treatment options with its mechanical flexibility and customisability to match individual needs, preventing post-surgery GBM recurrence and eventually prolonging the life expectancy of GBM patients. Full article
(This article belongs to the Special Issue Novel Controlled Release Drug Delivery Systems by Applying 3D Printing Technology)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop