Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
5.9
Journals
Nutrients
Special Issues
The Role of Diet in Pulmonary Diseases and Lung Development
nutrients-logo
Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

The Role of Diet in Pulmonary Diseases and Lung Development

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (26 October 2022) | Viewed by 8096

Special Issue Editors

Dr. Julia Schipke

E-Mail Website
Guest Editor
Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
Interests: nutrition; cardiopulmonary system; obesity; type 2 diabetes; spermidine; ultrastructure
Dr. Panagiota Mitrou

E-Mail Website
Guest Editor
Head of Independent Department of Therapeutic Protocols and Patient Registers, Hellenic Ministry of Health, Athens, Greece
Interests: diabetes; glucose metabolism; lipid metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inadequate nutritional supply, both pre- and postnatal, can affect cellular and extracellular functions, which are associated with impaired lung growth and development, and eventually may predispose to lung diseases in later life. Moreover, diet-related diseases, such as obesity and type 2 diabetes, are linked to a decline in lung function and an increased risk for chronic lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). There is increasing evidence that single nutrients, e.g., flavonoids or vitamin D, can exert beneficial effects on lung inflammation and disease progression. This underlines the importance of nutrition for lung health and indicates that specific dietary modifications can be useful as important supplementations for respiratory disease management and/or prevention.

The aim of this Special Issue is to bring together recent research on the role of diet composition or single nutrients on lung development or respiratory diseases. Original contributions, epidemiological studies, systematic reviews, and meta-analyses are welcome.

Dr. Julia Schipke
Dr. Panagiota Mitrou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • diet composition
  • lung development
  • pulmonary disease
  • obesity
  • type 2 diabetes
  • chronic obstructive pulmonary disease (COPD)
  • asthma

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

16 pages, 2376 KiB  
Article
Oral Supplementation with the Polyamine Spermidine Affects Hepatic but Not Pulmonary Lipid Metabolism in Lean but Not Obese Mice
by Sophia Pankoke, Christiane Pfarrer, Silke Glage, Christian Mühlfeld and Julia Schipke
Nutrients 2022, 14(20), 4318; https://doi.org/10.3390/nu14204318 - 15 Oct 2022
Viewed by 1930
Abstract
The polyamine spermidine is discussed as a caloric restriction mimetic and therapeutic option for obesity and related comorbidities. This study tested oral spermidine supplementation with regard to the systemic, hepatic and pulmonary lipid metabolism under different diet conditions. Male C57BL/6 mice were fed [...] Read more.
The polyamine spermidine is discussed as a caloric restriction mimetic and therapeutic option for obesity and related comorbidities. This study tested oral spermidine supplementation with regard to the systemic, hepatic and pulmonary lipid metabolism under different diet conditions. Male C57BL/6 mice were fed a purified control (CD), high sucrose (HSD) or high fat (HFD) diet with (-S) or without spermidine for 30 weeks. In CD-fed mice, spermidine decreased body and adipose tissue weights and reduced hepatic lipid content. The HSD induced hepatic lipid synthesis and accumulation and hypercholesterolemia. This was not affected by spermidine supplementation, but body weight and blood glucose were lower in HSD-S compared to HSD. HFD-fed mice showed higher body and fat depot weights, prediabetes, hypercholesterolemia and severe liver steatosis, which were not altered by spermidine. Within the liver, spermidine diminished hepatic expression of lipogenic transcription factors SREBF1 and 2 under HSD and HFD and affected the expression of other lipid-related enzymes. In contrast, diet and spermidine exerted only minor effects on pulmonary parameters. Thus, oral spermidine supplementation affects lipid metabolism in a diet-dependent manner, with significant reductions in body fat and weight under physiological nutrition and positive effects on weight and blood glucose under high sucrose intake, but no impact on dietary fat-related parameters. Full article
(This article belongs to the Special Issue The Role of Diet in Pulmonary Diseases and Lung Development)
►▼ Show Figures

Figure 1

13 pages, 2181 KiB  
Article
Oral Administration of Water Extract from Euglena gracilis Alters the Intestinal Microbiota and Prevents Lung Carcinoma Growth in Mice
by Deepa Upreti, Susumu Ishiguro, Nicole Robben, Ayaka Nakashima, Kengo Suzuki, Jeffrey Comer and Masaaki Tamura
Nutrients 2022, 14(3), 678; https://doi.org/10.3390/nu14030678 - 05 Feb 2022
Cited by 5 | Viewed by 3039
Abstract
The antitumor effects of a partially purified water extract from Euglena gracilis (EWE) and EWE treated by boiling (bEWE) were evaluated using orthotopic lung cancer syngeneic mouse models with Lewis lung carcinoma (LLC) cells. Daily oral administration of either EWE or bEWE started [...] Read more.
The antitumor effects of a partially purified water extract from Euglena gracilis (EWE) and EWE treated by boiling (bEWE) were evaluated using orthotopic lung cancer syngeneic mouse models with Lewis lung carcinoma (LLC) cells. Daily oral administration of either EWE or bEWE started three weeks prior to the inoculation of LLC cells significantly attenuated tumor growth as compared to the phosphate buffered saline (PBS) control, and the attenuation was further enhanced by bEWE. The intestinal microbiota compositions in both extract-treated groups were more diverse than that in the PBS group. Particularly, a decrease in the ratio of Firmicutes to Bacteroidetes and significant increases in Akkermansia and Muribaculum were observed in two types of EWE-treated groups. Fecal microbiota transplantation (FMT) using bEWE-treated mouse feces attenuated tumor growth to an extent equivalent to bEWE treatment, while tumor growth attenuation by bEWE was abolished by treatment with an antibiotic cocktail. These studies strongly suggest that daily oral administration of partially purified water extracts from Euglena gracilis attenuates lung carcinoma growth via the alteration of the intestinal microbiota. Full article
(This article belongs to the Special Issue The Role of Diet in Pulmonary Diseases and Lung Development)
►▼ Show Figures

Figure 1

Review

Jump to: Research

11 pages, 863 KiB  
Review
Non-Digestible Oligosaccharides: A Novel Treatment for Respiratory Infections?
by Yang Cai, Gert Folkerts and Saskia Braber
Nutrients 2022, 14(23), 5033; https://doi.org/10.3390/nu14235033 - 26 Nov 2022
Cited by 1 | Viewed by 2585
Abstract
Emerging antimicrobial resistance in respiratory infections requires novel intervention strategies. Non-digestible oligosaccharides (NDOs) are a diverse group of carbohydrates with broad protective effects. In addition to promoting the colonization of beneficial gut microbiota and maintaining the intestinal homeostasis, NDOs act as decoy receptors, [...] Read more.
Emerging antimicrobial resistance in respiratory infections requires novel intervention strategies. Non-digestible oligosaccharides (NDOs) are a diverse group of carbohydrates with broad protective effects. In addition to promoting the colonization of beneficial gut microbiota and maintaining the intestinal homeostasis, NDOs act as decoy receptors, effectively blocking the attachment of pathogens on host cells. NDOs also function as a bacteriostatic agent, inhibiting the growth of specific pathogenic bacteria. Based on this fact, NDOs potentiate the actions of antimicrobial drugs. Therefore, there is an increasing interest in characterizing the anti-infective properties of NDOs. This focused review provides insights into the mechanisms by which representative NDOs may suppress respiratory infections by targeting pathogens and host cells. We summarized the most interesting mechanisms of NDOs, including maintenance of gut microbiota homeostasis, interference with TLR-mediated signaling, anti-oxidative effects and bacterial toxin neutralization, bacteriostatic and bactericidal effects, and anti-adhesion or anti-invasive properties. A detailed understanding of anti-infective mechanisms of NDOs against respiratory pathogens may contribute to the development of add-on therapy or alternatives to antimicrobials. Full article
(This article belongs to the Special Issue The Role of Diet in Pulmonary Diseases and Lung Development)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop