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Nutrients
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Antitumor Effects of Dietary Compounds
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Antitumor Effects of Dietary Compounds

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (20 July 2021) | Viewed by 20335

Special Issue Editor

Dr. Kyung-Chul Choi

E-Mail Website
Guest Editor
College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Republic of Korea
Interests: biochemical toxicology; immunotoxicity; toxic mechanism; cancer biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past few decades, several natural compounds have been discovered that are now widely used as anti-cancer agents, including paclitaxel, vinblastine, camptothecin and oleuropein. In this Special Issue, we would like to highlight the effects of dietary compounds regarding anticancer activities and their underlying mechanisms in various in vitro or in vivo models.

Despite our understanding of the impact of diverse dietary phytochemicals on cancer growth and progression, our knowledge of their underlying mechanisms for anticancer activities of these phytochemicals still remains unknown.

This Special Issue will be helpful to give scientific insights of anticancer activities of phytochemicals for nutritional food ingredients to the readers. In this Special Issue, we would like to bring readers closer to the state-of-the-art in the field of nutritional phytochemicals by gathering papers that cover important aspects of underlying mechanisms of nutritional phytochemicals, especially those in cellular and animal models related with clinical relevance. Original research articles and reviews are greatly welcomed for the publication in the Nutrients.

Dr. Kyung-Chul Choi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antitumor effects
  • Dietary compounds
  • Food ingredients
  • Human cancers
  • Cell arrest and apoptosis

Published Papers (6 papers)

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Editorial

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3 pages, 183 KiB  
Editorial
Antitumor Effects of Dietary Compounds
by Zeeshan Ahmad Bhutta and Kyung-Chul Choi
Nutrients 2023, 15(10), 2349; https://doi.org/10.3390/nu15102349 - 17 May 2023
Viewed by 1189
Abstract
Cancer is reported to be a major cause of death worldwide, accounting for 10 million in 2020 based on 19 [...] Full article
(This article belongs to the Special Issue Antitumor Effects of Dietary Compounds)

Research

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27 pages, 10008 KiB  
Article
Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
by Marta Cykowiak, Violetta Krajka-Kuźniak, Robert Kleszcz, Małgorzata Kucińska, Hanna Szaefer, Hanna Piotrowska-Kempisty, Adam Plewiński, Marek Murias and Wanda Baer-Dubowska
Nutrients 2021, 13(9), 3000; https://doi.org/10.3390/nu13093000 - 28 Aug 2021
Cited by 12 | Viewed by 2466
Abstract
Background: Increasing evidence suggests that combinations of phytochemicals are more efficient than single components in the modulation of signaling pathways involved in cancer development. In this study, the impact of phenethyl isothiocyanate (PEITC), indole-3-carbinol (I3C), xanthohumol, (X), and resveratrol (RES) and their [...] Read more.
Background: Increasing evidence suggests that combinations of phytochemicals are more efficient than single components in the modulation of signaling pathways involved in cancer development. In this study, the impact of phenethyl isothiocyanate (PEITC), indole-3-carbinol (I3C), xanthohumol, (X), and resveratrol (RES) and their combinations on the activation and expression of Nrf2 and NF-κB in human hepatocytes and HCC cells were evaluated. Methods: THLE-2 and HepG2 cells were exposed to single phytochemicals and their combinations for 24 h. The activation of Nrf2 and NF-κB, expression of their target genes, and effect on cells survival were assessed. The tumor burden was evaluated in mice carrying xenografts. Results: All phytochemicals enhanced the activation and expression of Nrf2 and its target genes SOD and NQO1 in HepG2 cells. The increased expression of NQO1 (~90%) was associated with increased ROS generation. X + PEITC downregulated NF-κB activation reducing binding of its active subunits to DNA resulting in diminished COX-2 expression. In contrast to single phytochemicals, X + PEITC induced apoptosis. Moderate reduction of tumor burden in mice carrying xenografts following X and PEITC or their combination was observed. Conclusions: Since Nrf2 is overexpressed in HCC its reduced activation together with diminished level of NF-κB by X + PEITC may be considered as a strategy to support conventional HCC therapy. Full article
(This article belongs to the Special Issue Antitumor Effects of Dietary Compounds)
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16 pages, 1383 KiB  
Article
Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells
by Perrine Vermonden, Matthias Vancoppenolle, Emeline Dierge, Eric Mignolet, Géraldine Cuvelier, Bernard Knoops, Melissa Page, Cathy Debier, Olivier Feron and Yvan Larondelle
Nutrients 2021, 13(8), 2751; https://doi.org/10.3390/nu13082751 - 10 Aug 2021
Cited by 18 | Viewed by 4154
Abstract
Plant-derived conjugated linolenic acids (CLnA) have been widely studied for their preventive and therapeutic properties against diverse diseases such as cancer. In particular, punicic acid (PunA), a conjugated linolenic acid isomer (C18:3 c9t11c13) present at up to 83% in pomegranate seed oil, has [...] Read more.
Plant-derived conjugated linolenic acids (CLnA) have been widely studied for their preventive and therapeutic properties against diverse diseases such as cancer. In particular, punicic acid (PunA), a conjugated linolenic acid isomer (C18:3 c9t11c13) present at up to 83% in pomegranate seed oil, has been shown to exert anti-cancer effects, although the mechanism behind its cytotoxicity remains unclear. Ferroptosis, a cell death triggered by an overwhelming accumulation of lipid peroxides, has recently arisen as a potential mechanism underlying CLnA cytotoxicity. In the present study, we show that PunA is highly cytotoxic to HCT-116 colorectal and FaDu hypopharyngeal carcinoma cells grown either in monolayers or as three-dimensional spheroids. Moreover, our data indicate that PunA triggers ferroptosis in carcinoma cells. It induces significant lipid peroxidation and its effects are prevented by the addition of ferroptosis inhibitors. A combination with docosahexaenoic acid (DHA), a known polyunsaturated fatty acid with anticancer properties, synergistically increases PunA cytotoxicity. Our findings highlight the potential of using PunA as a ferroptosis-sensitizing phytochemical for the prevention and treatment of cancer. Full article
(This article belongs to the Special Issue Antitumor Effects of Dietary Compounds)
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Review

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14 pages, 1123 KiB  
Review
Potential Roles of Iridoid Glycosides and Their Underlying Mechanisms against Diverse Cancer Growth and Metastasis: Do They Have an Inhibitory Effect on Cancer Progression?
by Cho-Won Kim and Kyung-Chul Choi
Nutrients 2021, 13(9), 2974; https://doi.org/10.3390/nu13092974 - 26 Aug 2021
Cited by 28 | Viewed by 3058
Abstract
Iridoids are glycosides found in plants, having inherent roles in defending them against infection by viruses and microorganisms, and in the rapid repair of damaged areas. The emerging roles of iridoid glycosides on pharmacological properties have aroused the curiosity of many researchers, and [...] Read more.
Iridoids are glycosides found in plants, having inherent roles in defending them against infection by viruses and microorganisms, and in the rapid repair of damaged areas. The emerging roles of iridoid glycosides on pharmacological properties have aroused the curiosity of many researchers, and studies undertaken indicate that iridoid glycosides exert inhibitory effects in numerous cancers. This review focuses on the roles and the potential mechanism of iridoid glycosides at each stage of cancer development such as proliferation, epithelial mesenchymal transition (EMT), migration, invasion and angiogenesis. Overall, the reviewed literature indicates that iridoid glycosides inhibit cancer growth by inducing cell cycle arrest or by regulating apoptosis-related signaling pathways. In addition, iridoid glycosides suppress the expression and activity of matrix metalloproteinases (MMPs), resulting in reduced cancer cell migration and invasiveness. The antiangiogenic mechanism of iridoid glycosides was found to be closely related to the transcriptional regulation of pro-angiogenic factors, i.e., vascular endothelial growth factors (VEGFs) and cluster of differentiation 31 (CD31). Taken together, these results indicate the therapeutic potential of iridoid glycosides to alleviate or prevent rapid cancer progression and metastasis. Full article
(This article belongs to the Special Issue Antitumor Effects of Dietary Compounds)
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20 pages, 1304 KiB  
Review
Punicalagin in Cancer Prevention—Via Signaling Pathways Targeting
by Izabela Berdowska, Małgorzata Matusiewicz and Izabela Fecka
Nutrients 2021, 13(8), 2733; https://doi.org/10.3390/nu13082733 - 9 Aug 2021
Cited by 23 | Viewed by 4843
Abstract
The extract of pomegranate (Punica granatum) has been applied in medicine since ancient times due to its broad-spectrum health-beneficial properties. It is a rich source of hydrolyzable tannins and anthocyanins, exhibiting strong antioxidative, anti-inflammatory, and antineoplastic properties. Anticancer activities of pomegranate [...] Read more.
The extract of pomegranate (Punica granatum) has been applied in medicine since ancient times due to its broad-spectrum health-beneficial properties. It is a rich source of hydrolyzable tannins and anthocyanins, exhibiting strong antioxidative, anti-inflammatory, and antineoplastic properties. Anticancer activities of pomegranate with reference to modulated signaling pathways in various cancer diseases have been recently reviewed. However, less is known about punicalagin (Pug), a prevailing compound in pomegranate, seemingly responsible for its most beneficial properties. In this review, the newest data derived from recent scientific reports addressing Pug impact on neoplastic cells are summarized and discussed. Its attenuating effect on signaling circuits promoting cancer growth and invasion is depicted. The Pug-induced redirection of signal-transduction pathways from survival and proliferation into cell-cycle arrest, apoptosis, senescence, and autophagy (thus compromising neoplastic progression) is delineated. Considerations presented in this review are based mainly on data obtained from in vitro cell line models and concern the influence of Pug on human cervical, ovarian, breast, lung, thyroid, colorectal, central nervous system, bone, as well as other cancer types. Full article
(This article belongs to the Special Issue Antitumor Effects of Dietary Compounds)
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Other

25 pages, 2496 KiB  
Systematic Review
Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies
by Claudia Rita Corso, Natalia Mulinari Turin de Oliveira, Leonardo Moura Cordeiro, Karien Sauruk da Silva, Suzany Hellen da Silva Soczek, Virgilio Frota Rossato, Elizabeth Soares Fernandes and Daniele Maria-Ferreira
Nutrients 2021, 13(6), 2008; https://doi.org/10.3390/nu13062008 - 10 Jun 2021
Cited by 13 | Viewed by 3491
Abstract
Purpose: To review the effects of polysaccharides and their proposed mechanisms of action in breast cancer experimental models. Data sources, selection, and extraction: Articles were selected by using PubMed, ScienceDirect, Scopus, and Medline, assessed from 1 May 2019 to 1 July 2020. The [...] Read more.
Purpose: To review the effects of polysaccharides and their proposed mechanisms of action in breast cancer experimental models. Data sources, selection, and extraction: Articles were selected by using PubMed, ScienceDirect, Scopus, and Medline, assessed from 1 May 2019 to 1 July 2020. The systematic review was registered in the International Prospective Register of Systematic Reviews (Prospero) under the number CRD42020169103. Results: Most of the studies explore algae polysaccharides (43.2%), followed by mushrooms (13.5%), plants (13.5%), fruits (10.8%), fungus (2.7%), bacteria, (2.7%), and sea animals (2.7%). A total of 8.1% investigated only in vitro models, 62.1% evaluated only in vivo models, and 29.7% evaluated in vitro and in vivo models. The mechanism of action involves apoptosis, inhibition of cellular proliferation, angiogenesis, and antimetastatic effects through multiple pathways. Conclusions: Findings included here support further investigations on the anti-tumor effect of polysaccharides. Some polysaccharides, such as fucoidan and β-glucans, deserve detailed and structured studies aiming at translational research on breast tumors, since they are already used in the clinical practice of other proposals of human health. Full article
(This article belongs to the Special Issue Antitumor Effects of Dietary Compounds)
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