Roles of Migration and Invasion in Cancer Metastasis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 116
Special Issue Editor
Interests: biochemical toxicology; immunotoxicity; toxic mechanism; cancer biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer metastasis is the leading cause of cancer-related death in humans. This process is rooted in two steps crucial for cancer cell movement. Migration, the first step, includes the development of cancer within the primary tumor site, whereas invasion, the second step, involves dodging the physical barriers of the body such as blood vessels and the basement membrane to invade the secondary tumor site. Understanding the intricate roles these processes play in metastasis is crucial for developing effective therapies for control or treatment.
Considering the importance of migration and invasion in cancer cell metastasis, the current Special Issue welcomes studies across various disciplines, including:
- Molecular mechanisms: Analyzing the genetic changes and signaling mechanisms that control adhesion, cytoskeletal dynamics and cell motility.
- Cellular interactions: Investigating the functions of stromal cells in producing matrix remodeling enzymes, immunological regulators and growth factors that either promote or impede migration and invasion.
- Clinical implications: Creating novel diagnostic and therapeutic tools that target migration and invasion routes, identifying biomarkers linked to aggressive migration and invasion potential, and evaluating patient data to connect these processes with clinical results.
We invite researchers to contribute their diverse expertise, paving the way for a deeper understanding of this multifaceted process and ultimately, new avenues for combating cancer.
Dr. Kyung-Chul Choi
Guest Editor
Manuscript Submission Information
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Keywords
- cancer
- metastasis
- invasion
- migration
- tumor microenviornment
- epithelial–mesenchymal transition
- mesenchymal–epithelial transition
- intravasation
- extravasation
