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Role of Natural Food Extracts in Preventing or Treating the Side Effects Related to Radiotherapy and Chemotherapy

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 3432

Special Issue Editors


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Guest Editor
1. Gastroenterology Unit, Fondazione Policlinico Campus Biomedico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy
2. Department of Science and Technology for Humans and the Environment, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo 21, 00128 Rome, Italy
Interests: gastro-esophageal reflux disease; pathophysiology; diagnosis; and treatment; gas-trointestinal motility; functional disorders of the gastrointestinal tract; diagnosis and treatment of inflammatory bowel disease
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Department of Sciences and Technologies for Human and Environment, University Campus Bio-Medico of Rome, 00128 Rome, Italy
Interests: food chemistry; polyphenols; bioactive compounds; nutrients; nutraceuticals; an-tioxidant; HPLC; HPLC-MS
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Guest Editor
Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy
Interests: pancreatic neoplasms; head and neck neoplasms; clinical dosimetry; special techniques - modulated intensity radiation therapy, stereotaxy
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Special Issue Information

Dear Colleagues,

Radiotherapy and chemotherapy remain the major curative therapies for cancer; unfortunately, both of these therapeutical approaches are associated with adverse effects, such as gastrointestinal mucositis secondary to radiation injury or bacterial and fungal infections. Oral mucositis occurs in 40% to 80% of patients treated with radio- and chemotherapy and clinically appears as mild erythema in the non-keratinized mucosa and progresses to ulcers with extremely painful symptoms. It is known that cancer treatments change the microbial environment, favoring an increase in the prevalence of more pathogenic non-albicans Candida (NAC) and also different bacteria. Several strategies have been indicated for the treatment of mucositis, such as low-level laser treatment, the use of analgesics or anti-inflammatories, and cryotherapy. Recently, the use of natural compounds extracted by different kinds of food—such as aloe vera, Vitis vinifera extracts, Curcuma longa, Glycyrrhiza glabra, etc.—with phytotherapeutic effects represents an alternative that should be investigated due to their beneficial action in the prevention or treatment of radio- and chemotherapy side effects on the gastrointestinal mucosa.

Dr. Annamaria Altomare
Dr. Laura Dugo
Dr. Michele Fiore
Guest Editors

Manuscript Submission Information

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Keywords

  • gastrointestinal mucositis
  • oral mucositis
  • natural compounds
  • phytotherapeutic effect

Published Papers (1 paper)

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Review

21 pages, 401 KiB  
Review
Protective Role of Natural Compounds under Radiation-Induced Injury
by Annamaria Altomare, Michele Fiore, Gabriele D’Ercole, Elena Imperia, Roberta Maria Nicolosi, Susanna Della Posta, Gabriella Pasqua, Michele Cicala, Laura De Gara, Sara Ramella and Michele Pier Luca Guarino
Nutrients 2022, 14(24), 5374; https://doi.org/10.3390/nu14245374 - 17 Dec 2022
Cited by 3 | Viewed by 3056
Abstract
In recent years, evidence has shown the potential therapeutic effects of different natural compounds for the prevention and treatment of radiotherapy-induced mucositis (RIOM). RIOM represents one of the most frequent side effects associated with anti-neoplastic treatments affecting patients’ quality of life and treatment [...] Read more.
In recent years, evidence has shown the potential therapeutic effects of different natural compounds for the prevention and treatment of radiotherapy-induced mucositis (RIOM). RIOM represents one of the most frequent side effects associated with anti-neoplastic treatments affecting patients’ quality of life and treatment response due to radiation therapy discontinuation. The innate radio-protective ability of natural products obtained from plants is in part due to the numerous antioxidants possessed as a part of their normal secondary metabolic processes. However, oxygen presence is a key point for radiation efficacy on cancer cells. The aim of this review is to describe the most recent evidence on radiation-induced injury and the emerging protective role of natural compounds in preventing and treating this specific damage without compromising treatment efficacy. Full article
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