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Management of Non-alcoholic Fatty Liver Disease from Primary Care: Dietary and Nutritional Considerations (2nd Edition)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 4771

Special Issue Editors


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Guest Editor
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08303 Mataró, Spain
Interests: primary care medicine; clinical epidemiology; cohort studies; evidence-based medicine; clinical medicine; portfolio theory; diabetes; health; hypertension; preventive medicine
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Co-Guest Editor
Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundació Institut Universitari d’Investigació en Atenció Primària Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Mataró, Barcelona, Spain
Interests: primary care; non-alcoholic fatty liver disease

Special Issue Information

Dear Colleagues,

In recent years, non-alcoholic fatty liver disease (NAFLD) has become an emerging disease worldwide closely related to an increase in obesity and type 2 diabetes mellitus (T2DM). In fact, in Western countries, NAFLD has become the most common liver disease in both adult and paediatric populations. This pathology is closely related to metabolic syndrome (MS). Therefore, it is an important risk factor for the development of other comorbidities such as pre-diabetes, diabetes, insulin resistance, dyslipidaemia and cardiovascular diseases. Moreover, the presence of NAFLD, together with any of these comorbidities, is associated with increased cardiovascular and liver morbidity and mortality, including its progression to cirrhosis and hepatocarcinoma. However, we do not have sufficient data on the impact of NAFLD on the general population or the consequences it may have in the future.

Since obesity and NAFLD are very prevalent in our environment, they tend to be underestimated; however, they are potentially serious pathologies due to their association with multiple cardiovascular risk factors. Obesity at an early age is mostly related to cultural level, family socioeconomic status, and, especially, the lifestyle changes that have occurred over the last few years (e.g., the consumption of unhealthy food and sedentary habits). As a result, NAFLD leads to an increase in the overall burden of disease, causing a considerable expenditure of health resources and an increase in long-term mortality.

Primary care is the most appropriate setting for implementing early detection strategies as well as any intervention aimed at weight loss through nutrition and physical exercise. Framing this as a challenge for preventive practices provides an opportunity to avoid the development of advanced stages of this disease as well as its multiple associated comorbidities and complications.

Considering all this, in this Special Issue of Nutrients entitled "Management of Non-alcoholic Fatty Liver Disease from Primary Care: Dietary and Nutritional Considerations (2nd Edition)", we encourage researchers to submit articles that examine strategies for the early detection of NAFLD, its risk factors and interventions aimed at weight loss through physical exercise and especially nutrition.

Dr. Pere Torán-Monserrat
Guest Editors

Dr. Ingrid Arteaga
Co-Guest Editor

Manuscript Submission Information

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Keywords

  • NAFLD
  • metabolic syndrome
  • chronic liver disease
  • fibrosis
  • steatosis
  • primary care
  • nutrition
  • nutritional intervention
  • weight loss
  • prevention

Published Papers (2 papers)

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Research

13 pages, 761 KiB  
Article
Time-Restricted Fasting Improves Liver Steatosis in Non-Alcoholic Fatty Liver Disease—A Single Blinded Crossover Trial
by Jack Feehan, Alexandra Mack, Caroline Tuck, Jorge Tchongue, Darcy Q. Holt, William Sievert, Gregory T. Moore, Barbora de Courten and Alexander Hodge
Nutrients 2023, 15(23), 4870; https://doi.org/10.3390/nu15234870 - 22 Nov 2023
Cited by 1 | Viewed by 2450
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is associated with visceral adiposity. We assessed the effectiveness of time-restricted fasting (TRF) for 16 h daily without calorie restrictions compared to standard care (SC; diet and lifestyle advice) in improving visceral adiposity and steatosis via controlled [...] Read more.
Background: Non-alcoholic fatty liver disease (NAFLD) is associated with visceral adiposity. We assessed the effectiveness of time-restricted fasting (TRF) for 16 h daily without calorie restrictions compared to standard care (SC; diet and lifestyle advice) in improving visceral adiposity and steatosis via controlled attenuation parameter (CAP). Methods: In a prospective single-blind randomized controlled trial, 32 participants with NAFLD were randomly assigned to TRF or SC for 12 weeks. The secondary endpoints were changes in liver stiffness, anthropometry, blood pressure, and other metabolic factors. Results: Twenty-eight participants completed the first arm of the study (TRF = 14, SC = 14), with 23 completing the crossover arm (TRF = 10, SC = 13). The baseline demographics were similar between the groups. Intermittent fasting caused a significant decrease in hepatic steatosis (p = 0.038), weight (p = 0.005), waist circumference (p = 0.001), and BMI (p = 0.005) compared to standard care. Intermittent fasting also resulted in additional within-group changes that were not seen in the standard care intervention. Conclusion: TRF offers superior improvements in patients with NAFLD, improving steatosis, weight, and waist circumference despite a lack of change in overall caloric intake. Time-restricted fasting should be considered as a primary weight loss intervention in the context of NAFLD. Trial registration: ACTRN12613000935730. Full article
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11 pages, 648 KiB  
Article
High Extra Virgin Olive Oil Consumption Is Linked to a Lower Prevalence of NAFLD with a Prominent Effect in Obese Subjects: Results from the MICOL Study
by Calogero Claudio. Tedesco, Caterina Bonfiglio, Maria Notarnicola, Maria Rendina, Antonino Castellaneta, Alfredo Di Leo, Gianluigi Giannelli and Luigi Fontana
Nutrients 2023, 15(21), 4673; https://doi.org/10.3390/nu15214673 - 04 Nov 2023
Cited by 1 | Viewed by 1975
Abstract
Extra virgin olive oil (EVOO) has healthy benefits for noncommunicable diseases (NCDs). However, limited evidence is available about the effects of liver disease and non-alcoholic fatty liver disease (NAFLD). We evaluate whether dose-increased consumption of EVOO is associated with a lower prevalence of [...] Read more.
Extra virgin olive oil (EVOO) has healthy benefits for noncommunicable diseases (NCDs). However, limited evidence is available about the effects of liver disease and non-alcoholic fatty liver disease (NAFLD). We evaluate whether dose-increased consumption of EVOO is associated with a lower prevalence of NAFLD and if these effects vary based on body weight. The study included 2436 subjects with a 33% NAFLD prevalence. Daily EVOO was categorized into tertiles: low (0–24 g/day), moderate (25–37 g/day), and high consumption (>37 g/day). Subjects were also classified by body mass index (BMI) as normo-weight (18.5–24.9), overweight (25–29.9), and obese (≥30). Logistic regression analysis was applied to calculate odds ratios (ORs) for NAFLD, considering a 20-gram increment in EVOO intake and accounting for EVOO categories combined with BMI classes. The ORs were 0.83 (0.74;0.93) C.I. p = 0.0018 for continuous EVOO, 0.89 (0.69;1.15) C.I. p = 0.37, and 0.73 (0.55;0.97) C.I. p = 0.03 for moderate and high consumption, respectively, when compared to low consumption. Overall, the percent relative risk reductions (RRR) for NAFLD from low to high EVOO consumption were 18% (16.4%;19.2%) C.I. and 26% (25%;27.4%) C.I. in overweight and obese subjects. High EVOO consumption is associated with a reduced risk of NAFLD. This effect is amplified in overweight subjects and even more in obese subjects. Full article
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