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Nutrients
Special Issues
Dietary Strategies for Cerebrovascular Health: Prevention, Treatment, and Risk Factors
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Dietary Strategies for Cerebrovascular Health: Prevention, Treatment, and Risk Factors

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 3662

Special Issue Editors

Prof. Dr. Zoltan Benyo

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Guest Editor
Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary
Interests: physiology and pathophysiology of the cardiovascular system, with special emphasis on cerebral circulation
Prof. Dr. Vincenzo Lionetti

E-Mail Website
Guest Editor
Unit of Translational Critical Care Medicine, Interdisciplinary Research Center “Health Science”, Scuola Superiore Sant’Anna, 56127 Pisa, Italy
Interests: cardioprotection; perioperative medicine; translational medicine; intercellular communication; ristoceutica
Special Issues, Collections and Topics in MDPI journals
Dr. Stefano Tarantini

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Health Sciences Center, Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma, Oklahoma City, OK 73019, USA
Interests: hypertension; dietary interventions; high-fat diet; senescence; reactive oxygen species; senolytics; vascular biology; vascular imaging; cerebrovascular circulation; vascular physiology; microcirculation; cognitive aging; cerebral blood flow; laser Doppler flowmetry; mitochondria function
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cerebrovascular diseases, including ischemic as well as hemorrhagic strokes and vascular cognitive impairment, are leading global causes of mortality and disability. With increasing life expectancy, the burden on individuals and healthcare systems is set to grow. Emerging research highlights the critical role of nutrition in cerebrovascular health. Diet, an easily modifiable risk factor, offers promise for prevention and treatment. From nutritional supplements to altering food quantity, composition, and timing, dietary interventions hold potential in managing cerebrovascular, neurological, and neurodegenerative diseases. Time-restricted eating and intermittent fasting have garnered recent interest for their potential to alleviate cerebrovascular disorders by reducing oxidative stress, inflammation, and enhancing neuroprotection; however, rigorous experimental, epidemiological, and clinical studies are needed to establish their effectiveness and mechanisms. We invite original research articles and reviews to advance our understanding of dietary strategies for cerebrovascular health. Contribute to this vital conversation and help shape the future of cerebrovascular disease management. For submission guidelines and more information, visit https://www.mdpi.com/journal/nutrients/special_issues/VO60H70NOW.

Dr. Zoltan Benyo
Prof. Dr. Vincenzo Lionetti
Dr. Stefano Tarantini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cerebrovascular disorders
  • stroke
  • vascular cognitive impairment
  • metabolic diseases
  • time-restricted eating
  • intermittent fasting
  • vitamins
  • phytochemicals
  • oxidative stress
  • microbiome

Published Papers (2 papers)

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Research

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13 pages, 885 KiB  
Article
Association between Vitamin D and Short-Term Functional Outcomes in Acute Ischemic Stroke
by Min-Su Kim, Jin San Lee, Sung Joon Chung and Yunsoo Soh
Nutrients 2023, 15(23), 4957; https://doi.org/10.3390/nu15234957 - 29 Nov 2023
Viewed by 1117
Abstract
Vitamin D (Vit D) affects musculoskeletal performance and central nervous system neuroprotection. We aimed to investigate the association between serum Vit D levels and short-term functional outcomes in patients with acute ischemic stroke. This study involved patients with acute ischemic stroke confirmed on [...] Read more.
Vitamin D (Vit D) affects musculoskeletal performance and central nervous system neuroprotection. We aimed to investigate the association between serum Vit D levels and short-term functional outcomes in patients with acute ischemic stroke. This study involved patients with acute ischemic stroke confirmed on brain MRI. The National Institutes of Health Stroke Scale (NIHSS) was used to assess initial stroke severity upon admission. We evaluated the functional outcomes using the Berg Balance Scale (BBS), Manual Function Test (MFT), Korean Mini-Mental State Examination (K-MMSE), Korean version of the modified Barthel Index (K-MBI) within three weeks from the onset of stroke, and modified Rankin Scale (mRS) score at discharge. Overall, 192 patients were finally included and divided into three groups: Vit D sufficient (n = 28), insufficient (n = 49), and deficient (n = 115). Multivariate analysis showed that the Vit D deficient group presented with a higher risk of initially severe stroke (p = 0.025) and poor functional outcomes on the BBS (p = 0.048), MFT (p = 0.017), K-MMSE (p = 0.001), K-MBI (p = 0.003), and mRS (p = 0.032) compared to the Vit D sufficient group. Vit D deficiency may be associated with severe initial stroke and poor short-term post-stroke functional outcomes. Full article
(This article belongs to the Special Issue Dietary Strategies for Cerebrovascular Health: Prevention, Treatment, and Risk Factors)
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Review

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30 pages, 568 KiB  
Review
The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment
by Anna Ungvari, Rafal Gulej, Boglarka Csik, Peter Mukli, Sharon Negri, Stefano Tarantini, Andriy Yabluchanskiy, Zoltan Benyo, Anna Csiszar and Zoltan Ungvari
Nutrients 2023, 15(21), 4662; https://doi.org/10.3390/nu15214662 - 03 Nov 2023
Cited by 1 | Viewed by 2203
Abstract
As aging societies in the western world face a growing prevalence of vascular cognitive impairment and Alzheimer’s disease (AD), understanding their underlying causes and associated risk factors becomes increasingly critical. A salient concern in the western dietary context is the high consumption of [...] Read more.
As aging societies in the western world face a growing prevalence of vascular cognitive impairment and Alzheimer’s disease (AD), understanding their underlying causes and associated risk factors becomes increasingly critical. A salient concern in the western dietary context is the high consumption of methionine-rich foods such as red meat. The present review delves into the impact of this methionine-heavy diet and the resultant hyperhomocysteinemia on accelerated cerebrovascular and brain aging, emphasizing their potential roles in cognitive impairment. Through a comprehensive exploration of existing evidence, a link between high methionine intake and hyperhomocysteinemia and oxidative stress, mitochondrial dysfunction, inflammation, and accelerated epigenetic aging is drawn. Moreover, the microvascular determinants of cognitive deterioration, including endothelial dysfunction, reduced cerebral blood flow, microvascular rarefaction, impaired neurovascular coupling, and blood–brain barrier (BBB) disruption, are explored. The mechanisms by which excessive methionine consumption and hyperhomocysteinemia might drive cerebromicrovascular and brain aging processes are elucidated. By presenting an intricate understanding of the relationships among methionine-rich diets, hyperhomocysteinemia, cerebrovascular and brain aging, and cognitive impairment, avenues for future research and potential therapeutic interventions are suggested. Full article
(This article belongs to the Special Issue Dietary Strategies for Cerebrovascular Health: Prevention, Treatment, and Risk Factors)
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