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Nutrients
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The Role of Diet and Lifestyle in the Pathophysiology and...
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The Role of Diet and Lifestyle in the Pathophysiology and Management of NAFLD

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 15 May 2024 | Viewed by 1154

Special Issue Editor

Prof. Dr. Daniel Cuthbertson

E-Mail Website
Guest Editor
Institute of Life Course and Medical Sciences, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, UK
Interests: insulin resistance; obesity; insulin signalling; AMPK; skeletal muscle; NASH; PCOS; magnetic resonance spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

NAFLD is the most common liver disease worldwide, and there is no effective drug therapy for this condition currently. This Special Issue will explore the detrimental impact of poor diet and/or physical inactivity on NAFLD’s pathophysiology and associated extra-hepatic outcomes through interacting with genetic factors. This may be related to such dietary factors as different macronutrient compositions, different relative intakes of plant vs. meat-based products, sugar-sweetened beverages or ultraprocessed foods, with examples from overfeeding/inactivity studies. Additionally, the Special Issue will explore the impact of dietary modifications (e.g., intermittent fasting, time-restricted feeding, low-carb or low-calorie diets). We will also explore the impact of physical activity modulation, including walking-based, aerobic, resistance, or high-intensity interval training.

Considering the success of the previous Special Issue, entitled "From NAFLD to MAFLD: The Role of Diet and Lifestyle in Its Pathophysiology and Treatment", we are pleased to announce that we are launching a second Special Issue on this topic.

Prof. Dr. Daniel Cuthbertson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • NAFLD
  • metabolic
  • physical inactivity
  • exercise
  • diet
  • ultraprocessed food
  • sugar-sweetened beverages

Published Papers (1 paper)

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19 pages, 2888 KiB  
Systematic Review
Effect of a Low-Calorie Dietary Intervention on Liver Health and Body Weight in Adults with Metabolic-Dysfunction Associated Steatotic Liver Disease (MASLD) and Overweight/Obesity: A Systematic Review and Meta-Analysis
by Laurence J. Dobbie, Jamie Burgess, Azlinda Hamid, Sarah J. Nevitt, Theresa J. Hydes, Uazman Alam and Daniel J. Cuthbertson
Nutrients 2024, 16(7), 1030; https://doi.org/10.3390/nu16071030 - 01 Apr 2024
Viewed by 944
Abstract
Introduction: Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD) is a common cause of chronic liver disease. This review assessed the efficacy of a Low-Calorie Diet (LCD) on liver health and body weight in people living with MASLD and obesity. Methods: The study was registered [...] Read more.
Introduction: Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD) is a common cause of chronic liver disease. This review assessed the efficacy of a Low-Calorie Diet (LCD) on liver health and body weight in people living with MASLD and obesity. Methods: The study was registered with PROSPERO (CRD42021296501), and a literature search was conducted using multiple databases. The key inclusion criteria were randomised controlled trials or cohort studies, obesity/overweight and MASLD. Two authors screened abstracts, reviewed full texts and performed data extraction and quality assessment. The primary outcome was the change in the serum ALT, and secondary outcomes included the changes in the serum AST, intrahepatic lipid content (IHL), quantified non-invasively via MRI/MRS, and body weight. Results: Fifteen studies were included. The LCD reduced body weight by 9.1 kg versus the control (95%CI: −12.4, −5.8) but not serum ALT (−5.9 IU/L, −13.9, 2.0). Total Dietary Replacement (TDR) reduced IHL by −9.1% vs. the control (−15.6%, −2.6%). The Mediterranean-LCD for ≥12 months reduced ALT (−4.1 IU/L, −7.6, −0.5) and for 24 months reduced liver stiffness versus other LCDs. The Green-Mediterranean-LCD reduced IHL, independent of body weight. Limited studies assessed those of Black or Asian ethnicity, and there was heterogeneity in the methods assessing the liver fat content and fibrosis. Conclusions: In people with MASLD and obesity, an LCD intervention reduces IHL and body weight. Trials should focus on the recruitment of Black and Asian ethnicity participants. Full article
(This article belongs to the Special Issue The Role of Diet and Lifestyle in the Pathophysiology and Management of NAFLD)
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