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Nutrients
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The Protective Effects of Botanical Dietary Supplements on Neurological Diseases
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The Protective Effects of Botanical Dietary Supplements on Neurological Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 13125

Special Issue Editor

Dr. Jianmei Li

E-Mail Website
Guest Editor
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China
Interests: botanical dietary supplements; intestinal flora; metabolism; neurological diseases

Special Issue Information

Dear Colleagues,

Botanical dietary supplements (BDSs) are a subset of botanical products containing one or more dietary ingredients (including vitamins, minerals, herbs or other botanicals, amino acids, dietary fiber or other substances) or their constituents that are used to maintain or improve health. BDSs are growing popularly for the prevention and modification of vascular, inflammatory and degenerative diseases. Therefore, the effective utilization and accurate evaluation of BDSs are key to making use of them as health-promotion factors.

Mental, neurological and substance-use disorders presently represent the greatest burden of disease globally. Nutritional support is already an integral part of disease prevention and treatment in hospital. The aim of this Special Issue is to attract original research and review articles focusing on the beneficial effects of BDSs on neurological diseases including Parkinson’s disease, insomnia, stroke, depression, migraine, dementia, addiction, etc.

Dr. Jianmei Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • botanical dietary supplements
  • botanical products
  • dietary ingredients
  • disease prevention
  • disease modification
  • neurological diseases
  • Parkinson’s disease
  • insomnia
  • stroke
  • depression
  • migraine
  • dementia
  • addiction

Published Papers (4 papers)

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Research

13 pages, 3456 KiB  
Article
Luteolin-7-O-Glucuronide Improves Depression-like and Stress Coping Behaviors in Sleep Deprivation Stress Model by Activation of the BDNF Signaling
by Dajung Ryu, Hye-Jin Jee, Sang-Yoon Kim, Seung-Hwan Hwang, Gam-Bang Pil and Yi-Sook Jung
Nutrients 2022, 14(16), 3314; https://doi.org/10.3390/nu14163314 - 12 Aug 2022
Cited by 17 | Viewed by 2497
Abstract
Stress exposure is a major risk factor for mental disorders such as depression. Because of the limitations of classical antidepressants such as side effects, low efficacy, and difficulty in long-term use, new natural medicines and bioactive molecules from plants with greater safety and [...] Read more.
Stress exposure is a major risk factor for mental disorders such as depression. Because of the limitations of classical antidepressants such as side effects, low efficacy, and difficulty in long-term use, new natural medicines and bioactive molecules from plants with greater safety and efficacy have recently attracted attention. Luteolin-7-O-glucuronide (L7Gn), a bioactive molecule present in Perilla frutescens, is known to alleviate severe inflammatory responses and oxidative stress in macrophages. However, its antistress and antidepressant effects have not been elucidated. The present study aims to explore the antidepressant the effect of L7Gn on stress-induced behaviors and the underlying mechanism in a mouse sleep deprivation (SD) model. L7Gn treatment improved depression-like and stress coping behaviors induced by SD stress, as confirmed by the tail suspension test and forced swimming test. Furthermore, L7Gn treatment reduced the blood corticosterone and hippocampal proinflammatory cytokine levels which were increased by SD stress, and L7Gn also increased the mRNA and protein levels of hippocampal brain-derived neurotrophic factor (BDNF) which were reduced by SD stress. Additionally, treatment with L7Gn resulted in increases in the phosphorylation of tropomyosin-related kinase B (TrkB), extracellular signal-regulated kinase (ERK), and cAMP response element-binding protein (CREB), which are downstream molecules of BDNF signaling. These findings suggest that L7Gn have therapeutic potential for SD-induced stress, via activating the BDNF signaling. Full article
(This article belongs to the Special Issue The Protective Effects of Botanical Dietary Supplements on Neurological Diseases)
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12 pages, 1409 KiB  
Article
Improvement of Depressed Mood with Green Tea Intake
by Keiko Unno, Daisuke Furushima, Yuya Tanaka, Takeichiro Tominaga, Hirotomo Nakamura, Hiroshi Yamada, Kyoko Taguchi, Toshinao Goda and Yoriyuki Nakamura
Nutrients 2022, 14(14), 2949; https://doi.org/10.3390/nu14142949 - 19 Jul 2022
Cited by 4 | Viewed by 3920
Abstract
Being in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on [...] Read more.
Being in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on the biological stress response and inflammation in the brain. Regarding the stress reduction effect of green tea, we found that the sum of caffeine (C) and epigallocatechin gallate (E) relative to the sum of theanine (T) and arginine (A), the major components of green tea, or the CE/TA ratio, is important. The results showed that depression-like behavior, adrenal hypertrophy as a typical stress response, and brain inflammation were suppressed in mice fed green tea components with CE/TA ratios of 2 to 8. In addition, the expression of Npas4, which is reduced in anxiety and depression, was maintained at the same level as controls in mice that consumed green tea with a CE/TA ratio of 4. In clinical human trials, the consumption of green tea with CE/TA ratios of 3.9 and 4.7 reduced susceptibility to subjective depression. These results suggest that the daily consumption of green tea with a CE/TA ratio of 4–5 is beneficial to improving depressed mood. Full article
(This article belongs to the Special Issue The Protective Effects of Botanical Dietary Supplements on Neurological Diseases)
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13 pages, 3841 KiB  
Article
Gypenoside XVII, an Active Ingredient from Gynostemma Pentaphyllum, Inhibits C3aR-Associated Synaptic Pruning in Stressed Mice
by Man-Man Zhang, Guo-Ming Huo, Jie Cheng, Qiu-Ping Zhang, Na-Zhi Li, Min-Xia Guo, Qing Liu, Guang-Hui Xu, Ji-Xiao Zhu, Cheng-Fu Li, Feng Zhou and Li-Tao Yi
Nutrients 2022, 14(12), 2418; https://doi.org/10.3390/nu14122418 - 10 Jun 2022
Cited by 8 | Viewed by 2359
Abstract
Gynostemma pentaphyllum is a herbal medicine widely used in Asian countries, and its saponin extracts have been shown to possess potent anti-inflammatory effects. Gypenoside XVII, an active ingredient isolated from Gynostemma pentaphyllum, has been found to alleviate the inflammation induced by LPS in [...] Read more.
Gynostemma pentaphyllum is a herbal medicine widely used in Asian countries, and its saponin extracts have been shown to possess potent anti-inflammatory effects. Gypenoside XVII, an active ingredient isolated from Gynostemma pentaphyllum, has been found to alleviate the inflammation induced by LPS in the BV2 microglia, according to our preliminary study. This study aims to evaluate whether Gypenoside XVII could attenuate depression-like symptoms in vivo and tries to demonstrate the involvement of the complement regulation in its antidepressant-like effect. The results showed that Gypenoside XVII significantly attenuated depression-like behaviors in the forced swimming test, tail suspension test and sucrose preference test. It also alleviated the acute stress-induced hyperactivity of serum corticosterone levels. Additionally, Gypenoside XVII significantly inhibited the activation of microglia and the expression of C3 in mice exposed to chronic unpredictable mild stress (CUMS). Meanwhile, the activation of C3aR/STAT3 signaling and the expression of proinflammatory cytokines was reversed by Gypenoside XVII. Moreover, CUMS induced excessive synaptic pruning by activating microglia, while Gypenoside XVII restored it in the prefrontal cortex. Our data demonstrated that Gypenoside XVII, the active ingredient of Gynostemma pentaphyllum, produced the antidepressant-like effects in mice, which was mediated by the inhibition of complement C3/C3aR/STAT3/cytokine signaling in the prefrontal cortex. Full article
(This article belongs to the Special Issue The Protective Effects of Botanical Dietary Supplements on Neurological Diseases)
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15 pages, 5270 KiB  
Article
Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage
by Chuan-Feng Tang, Cong-Ying Wang, Jun-Han Wang, Qiao-Na Wang, Shen-Jie Li, Hai-Ou Wang, Feng Zhou and Jian-Mei Li
Nutrients 2022, 14(9), 1882; https://doi.org/10.3390/nu14091882 - 29 Apr 2022
Cited by 26 | Viewed by 3839
Abstract
Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood–brain barrier (BBB) damage, accompanied [...] Read more.
Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood–brain barrier (BBB) damage, accompanied by the reduction of gut microbiome-derived short-chain fatty acids (SCFAs). Here, we found that chronic stress aggravated these pathological changes and promoted the development of depressive-like behaviors in FruD mice. In detail, the decreased number of newborn neurons, mature neurons and neural stem cells (NSCs) in the hippocampus of FruD mice was worsened by chronic stress. Furthermore, chronic stress exacerbated the damage of BBB integrity with the decreased expression of zonula occludens-1 (ZO-1), claudin-5 and occludin in brain vasculature, overactivated microglia and increased neuroinflammation in FruD mice. These results suggest that high fructose intake combined with chronic stress leads to cumulative negative effects that promote the development of depressive-like behaviors in mice. Of note, SCFAs could rescue hippocampal neurogenesis decline, improve BBB damage and suppress microglia activation and neuroinflammation, thereby ameliorate depressive-like behaviors of FruD mice exposed to chronic stress. These results could be used to develop dietary interventions to prevent depression. Full article
(This article belongs to the Special Issue The Protective Effects of Botanical Dietary Supplements on Neurological Diseases)
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