Special Issue "Nutritional Strategies in the Prevention and Treatment of Metabolic Syndrome"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 March 2024 | Viewed by 388

Special Issue Editors

Department of Food Engineering, Sichuan University, Chengdu 610065, China
Interests: food nutrition and health
Special Issues, Collections and Topics in MDPI journals
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Interests: functional foods; phytochemicals; chronic disease; skeletal muscle atrophy; photoaging; gut health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic syndrome, which is a cluster of comorbid conditions, including obesity, hypertension, and disordered carbohydrate, and lipid metabolism constitutes a significant health and social problem around the world. Metabolic syndrome can lead to several serious and chronic complications, including type 2 diabetes, cardiovascular diseases, stroke, kidney disease, and nonalcoholic fatty liver disease. The most important risk factors are diet (particularly sugar-sweetened beverage consumption), genetics, aging, low physical activity, and excessive alcohol use. The management of metabolic syndrome is a complex and multifaceted process including drug therapy and lifestyle interventions. Evidence from various preclinical and clinical studies has revealed that various dietary components (nutrients, phytochemicals, prebiotics/probiotics, etc.) play a significant role in the prevention and treatment of metabolic syndrome and emerge as potential therapeutic agents in a broad range of metabolic syndrome models.

This Special Issue aims to provide current contemporary knowledge on the effects of dietary components (nutrients, phytochemicals, prebiotics/probiotics, etc.) on metabolic syndrome, with the ultimate aim of offering new insights into potential preventive or therapeutic approaches (dietary and pharmacological intervention) for the clinical management of metabolic syndrome.

We warmly welcome reviews (systematic reviews and meta-analyses),original research articles, and clinical studies to be submitted to this Special Issue.

Dr. Weicai Zeng
Dr. Tao Tong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary intervention
  • phytochemical
  • plant polyphenols
  • tea polyphenols
  • nutraceutical
  • prebiotics/probiotics
  • metabolic syndrome
  • high-fat diet
  • obesity
  • type 2 diabetes
  • diabetic nephropathy
  • diabetic cardiomyopathy
  • nonalcoholic steatohepatitis
  • skeletal muscle atrophy
  • sarcopenia

Published Papers (1 paper)

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Research

16 pages, 5808 KiB  
Article
Properties of Dietary Flavone Glycosides, Aglycones, and Metabolites on the Catalysis of Human Endoplasmic Reticulum Uridine Diphosphate Glucuronosyltransferase 2B7 (UGT2B7)
Nutrients 2023, 15(23), 4941; https://doi.org/10.3390/nu15234941 - 28 Nov 2023
Viewed by 98
Abstract
Flavone glycosides, their aglycones, and metabolites are the major phytochemicals in dietary intake. However, there are still many unknowns about the cellular utilization and active sites of these natural products. Uridine diphosphate glucuronosyltransferases (UGTs) in the endoplasmic reticulum have gene polymorphism distribution in [...] Read more.
Flavone glycosides, their aglycones, and metabolites are the major phytochemicals in dietary intake. However, there are still many unknowns about the cellular utilization and active sites of these natural products. Uridine diphosphate glucuronosyltransferases (UGTs) in the endoplasmic reticulum have gene polymorphism distribution in the population and widely mediate the absorption and metabolism of endogenous and exogenous compounds by catalyzing the covalent addition of glucuronic acid and various lipophilic chemicals. Firstly, we found that rutin, a typical flavone O-glycoside, has a stronger UGT2B7 binding effect than its metabolites. After testing a larger number of flavonoids with different aglycones, their aglycones, and metabolites, we demonstrated that typical dietary flavone O-glycosides generally have high binding affinities towards UGT2B7 protein, but the flavone C-glycosides and the phenolic acid metabolites of flavones had no significant effect on this. With the disposition of 4-methylumbelliferone examined by HPLC assay, we determined that 10 μM rutin and nicotifiorin could significantly inhibit the activity of recombinant UGT2B7 protein, which is stronger than isovitexin, vitexin, 3-hydroxyphenylacetic acid and 3,4-dihydroxyphenylacetic acid. In addition, in vitro experiments showed that in normal and doxorubicin-induced lipid composition, both flavone O-glycosides rutin and flavone C-glycosides isovitexin at 10 μM had no significant effect on the expression of UGT1A1, UGT2B4, UGT2B7, and UGT2B15 genes for 24 h exposure. The obtained results enrich the regulatory properties of dietary flavone glycosides, aglycones, and metabolites towards the catalysis of UGTs and will contribute to the establishment of a precise nutritional intervention system based on lipid bilayers and theories of nutrients on endoplasmic reticulum and mitochondria communication. Full article
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