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Nutrients
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Neonatal Nutrition
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Neonatal Nutrition

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: closed (30 June 2019) | Viewed by 17163

Special Issue Editor

Prof. Dr. Colin Morgan

E-Mail Website
Guest Editor
Department of Neonatology, Liverpool Women’s Hospital, Liverpool L8 7SS, UK
Interests: neonatal nutrition and metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of neonatal nutrition is becoming increasingly complex as the clinical benefits of optimal nutrition become clearer and potential therapeutic options for early nutritional intervention increase. The problem of postnatal growth failure in very preterm infants suggests that there is still much to improve in the field of neonatal nutrition. However, nutrition has a much broader scope than simply monitoring a growth trajectory. The role of early nutrition in growth, neurodevelopment and long-term health is well recognised. More recent evidence indicates individual nutritional components affect postnatal metabolic adaption, inflammatory pathways and the developing immune system. This has the potential to influence the short-term recovery of the sick and/or preterm neonate as well as longer-term clinical needs. The transition from parenteral to enteral feeding creates many clinical controversies as does the challenge of providing mothers’ own milk or choosing an alternative when none is available. I invite authors to submit papers considering neonatal nutrition in its widest sense.

Dr. Colin Morgan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parenteral Nutrition
  • Human milk
  • Glucose metabolism
  • Protein
  • Lipid
  • Energy intake
  • Lactation
  • Amino acid metabolism
  • Formulation
  • Preterm
  • Micronutrients
  • Immunonutrition

Published Papers (2 papers)

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Research

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11 pages, 251 KiB  
Article
Attainment Targets for Protein Intake Using Standardised, Concentrated and Individualised Neonatal Parenteral Nutrition Regimens
by Colin Morgan and Maw Tan
Nutrients 2019, 11(9), 2167; https://doi.org/10.3390/nu11092167 - 10 Sep 2019
Cited by 4 | Viewed by 2770
Abstract
Neonatal parenteral nutrition (NPN) regimens that are individualised (iNPN) or standardised concentrated NPN (scNPN) are both currently used in preterm clinical practice. Two recent trials (one iNPN and one scNPN) each compared standard (control) and high (intervention) parenteral protein and energy dosage regimens [...] Read more.
Neonatal parenteral nutrition (NPN) regimens that are individualised (iNPN) or standardised concentrated NPN (scNPN) are both currently used in preterm clinical practice. Two recent trials (one iNPN and one scNPN) each compared standard (control) and high (intervention) parenteral protein and energy dosage regimens and provided data about actual protein intake. We hypothesised that scNPN regimens would achieve a higher percentage of the target parenteral protein intake than their corresponding iNPN regimens. We calculated the daily individual target parenteral protein intake and used the daily parenteral protein intake to calculate the target attainment for protein intake in each infant for the two control (iNPN: n = 59, scNPN: n = 76) and two intervention (iNPN: n = 65; scNPN: n = 74) groups. The median (IQR) target attainment of high-dose protein was 75% (66–85) versus 94% (87–97) on days 1–15 for iNPN and scNPN regimens respectively (p < 0.01). The median (IQR) target attainment of standard dose protein was 77% (67–85) versus 94% (91–96) on days 1–15 for iNPN and scNPN regimens, respectively (p < 0.01). This was associated with improved weight gain (p = 0.050; control groups only) and head growth (p < 0.001; intervention groups only). scNPN regimens have better target attainment for parenteral protein intakes than iNPN regimens. Full article
(This article belongs to the Special Issue Neonatal Nutrition)

Review

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24 pages, 1370 KiB  
Review
The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review
by Barbara E. Cormack, Jane E. Harding, Steven P. Miller and Frank H. Bloomfield
Nutrients 2019, 11(9), 2029; https://doi.org/10.3390/nu11092029 - 30 Aug 2019
Cited by 104 | Viewed by 13803
Abstract
Extremely preterm babies are at increased risk of less than optimal neurodevelopment compared with their term-born counterparts. Optimising nutrition is a promising avenue to mitigate the adverse neurodevelopmental consequences of preterm birth. In this narrative review, we summarize current knowledge on how nutrition, [...] Read more.
Extremely preterm babies are at increased risk of less than optimal neurodevelopment compared with their term-born counterparts. Optimising nutrition is a promising avenue to mitigate the adverse neurodevelopmental consequences of preterm birth. In this narrative review, we summarize current knowledge on how nutrition, and in particular, protein intake, affects neurodevelopment in extremely preterm babies. Observational studies consistently report that higher intravenous and enteral protein intakes are associated with improved growth and possibly neurodevelopment, but differences in methodologies and combinations of intravenous and enteral nutrition strategies make it difficult to determine the effects of each intervention. Unfortunately, there are few randomized controlled trials of nutrition in this population conducted to determine neurodevelopmental outcomes. Substantial variation in reporting of trials, both of nutritional intakes and of outcomes, limits conclusions from meta-analyses. Future studies to determine the effects of nutritional intakes in extremely preterm babies need to be adequately powered to assess neurodevelopmental outcomes separately in boys and girls, and designed to address the many potential confounders which may have clouded research findings to date. The development of minimal reporting sets and core outcome sets for nutrition research will aid future meta-analyses. Full article
(This article belongs to the Special Issue Neonatal Nutrition)
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