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Nutritional Regulation of Gut Microbial Composition and Metabolism: Impact on Obesity

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 4020

Special Issue Editor


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Guest Editor
Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, Diabetes Institute, University of Washington, Seattle, WA, USA
Interests: obesity; nutrition; inflammation; adipose tissue; macrophages; fatty acids; atherosclerosis

Special Issue Information

Dear Colleagues,

Obesity has reached epidemic proportions, necessitating the development of novel strategies for weight loss. It is becoming increasingly clear that there is a link between obesity and the gut microbiota. The specific bacterial populations that inhabit our gut can have substantial metabolic impact in relation to obesity through mechanisms involving the gut–brain, gut–liver, and gut–adipose axes. The nutrient composition of the diet can greatly impact gut microbial populations, selecting for particular taxa possessing specific enzymatic pathways that can differentially utilize various dietary substrates. Thus, dietary strategies that aim to perturb the gut microbiota could modulate obesity and its co-morbidities including diabetes and cardiovascular disease.

This collection will highlight how the gut microbiota can be regulated by dietary perturbations, and how these gut microbial changes can in turn modulate obesity and its co-morbidities. This Special Issue seeks original basic, preclinical, and translational research papers, and welcomes comprehensive review articles and short communications within the scope presented. Potential topics include but are not limited to:

  • Dietary modulators of microbial composition;
  • Microbial metabolites;
  • Dietary regulation of the gut–brain axis;
  • Gut microbiota and adipokines;
  • Gut microbiota and weight loss;
  • Dietary modulators of intestinal permeability;
  • Gut microbial health and diabetes/CVD;
  • Nutritional impacts on gut immunity/inflammation.

Dr. Laura J. den Hartigh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Diabetes
  • Cardiovascular disease
  • Metabolic disease
  • Microbiota
  • Metabolites
  • Weight loss
  • Intestinal permeability
  • Probiotics
  • Prebiotics
  • Immunity and inflammation

Published Papers (1 paper)

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18 pages, 813 KiB  
Systematic Review
Impact of Food-Based Weight Loss Interventions on Gut Microbiome in Individuals with Obesity: A Systematic Review
by Aleisha Bliesner, Jade Eccles-Smith, Claire Bates, Olivia Hayes, Jet Yee Ho, Catia Martins, Helen Truby and Marloes Dekker Nitert
Nutrients 2022, 14(9), 1953; https://doi.org/10.3390/nu14091953 - 6 May 2022
Cited by 8 | Viewed by 3584
Abstract
The observation that the gut microbiota is different in healthy weight as compared with the obese state has sparked interest in the possible modulation of the microbiota in response to weight change. This systematic review investigates the effect of food-based weight loss diets [...] Read more.
The observation that the gut microbiota is different in healthy weight as compared with the obese state has sparked interest in the possible modulation of the microbiota in response to weight change. This systematic review investigates the effect of food-based weight loss diets on microbiota outcomes (α-diversity, β-diversity, relative bacterial abundance, and faecal short-chain fatty acids, SCFAs) in individuals without medical comorbidities who have successfully lost weight. Nineteen studies were included using the keywords ‘obesity’, ‘weight loss’, ‘microbiota’, and related terms. Across all 28 diet intervention arms, there were minimal changes in α- and β-diversity and faecal SCFA concentrations following weight loss. Changes in relative bacterial abundance at the phylum and genus level were inconsistent across studies. Further research with larger sample sizes, detailed dietary reporting, and consistent microbiota analysis techniques are needed to further our understanding of the effect of diet-induced weight loss on the gut microbiota. Full article
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