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Nutrients
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The Effects of Dietary Fat on Gut Microbiota and Metabolic...
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The Effects of Dietary Fat on Gut Microbiota and Metabolic Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 22083

Special Issue Editors

Prof. Dr. Rita Guimarães

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Guest Editor
Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Brazil
Interests: experimental nutrition; metabolism; food analysis; development of new products and food chemistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Arnildo Pott

E-Mail Website
Guest Editor
Institute of Biosciences, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79079-900, Brazil
Interests: medicinal plants; nuts; food; nutrition; technology
Prof. Dr. Priscila Hiane

E-Mail Website
Guest Editor
Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul (UFMS), Campo Grande 79070-900, Brazil
Interests: experimental nutrition; metabolism; nutraceutical compounds; food analysis; Brazilian nuts; food chemistry

Special Issue Information

Dear Colleagues,

Non-transmissible chronic diseases (NTCDs) are a big concern worldwide, primarily due to persistent inflammation and altered food ingestion. In recent years, a substantial piece of research addressed the impact of nutrition on several NTCDs, such as metabolic syndrome (MS), type II diabetes mellitus, obesity, dyslipidemia, cardiometabolic disease, and related disorders. Food lipids are fundamental in this aspect, especially in metabolic syndrome, mediating the gut microbiota. The characteristics of consumed fatty acids are crucial in such diseases, mainly when we highlight the essential polyunsaturated fatty acids (PUFAs). Nutraceutical foods are essential in the action mechanisms of comorbidities since healthy lifestyles and food chemical characteristics can attenuate them. Genetic predisposition is strongly related to metabolic changes. Several pre-clinical and clinical studies have been developed to show the importance of such alterations over life, demonstrating the importance of nutrigenomic studies.

Authors are invited to contribute original research in vitro and analytical studies on animals and humans with novel results. Narrative systematic reviews or meta-analyses will also be accepted.

Prof. Dr. Rita Guimarães
Prof. Dr. Arnildo Pott
Prof. Dr. Priscila Hiane
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • lipids
  • non-transmissible chronic diseases
  • gut microbiota
  • metabolic syndrome
  • nutraceutical and functional foods
  • inflammation
  • fatty acids
  • cytokines
  • medicinal plants

Published Papers (2 papers)

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Research

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17 pages, 6249 KiB  
Article
Time-Restricted Feeding Modifies the Fecal Lipidome and the Gut Microbiota
by Bret M. Rust, Matthew J. Picklo, Lin Yan, Aaron A. Mehus and Huawei Zeng
Nutrients 2023, 15(7), 1562; https://doi.org/10.3390/nu15071562 - 23 Mar 2023
Cited by 1 | Viewed by 2572
Abstract
Time-restricted feeding (TRF) has been identified as an approach to reduce the risk of obesity-related metabolic diseases. We hypothesize that TRF triggers a change in nutrient (e.g., dietary fat) absorption due to shortened feeding times, which subsequently alters the fecal microbiome and lipidome. [...] Read more.
Time-restricted feeding (TRF) has been identified as an approach to reduce the risk of obesity-related metabolic diseases. We hypothesize that TRF triggers a change in nutrient (e.g., dietary fat) absorption due to shortened feeding times, which subsequently alters the fecal microbiome and lipidome. In this report, three groups of C57BL/6 mice were fed either a control diet with ad libitum feeding (16% energy from fat) (CTRL-AL), a high-fat diet (48% energy from fat) with ad libitum feeding (HF-AL), or a high-fat diet with time-restricted feeding (HF-TRF) for 12 weeks. No changes in microbiota at the phylum level were detected, but eight taxonomic families were altered by either feeding timing or dietary fat content. The HF-AL diet doubled the total fecal fatty acid content of the CTRL-AL diet, while the HF-TRF doubled the total fecal fatty acid content of the HF-AL diet. Primary fecal bile acids were unaffected by diet. Total short-chain fatty acids were reduced by HF-AL, but this effect was diminished by HF-TRF. Each diet produced distinct relationships between the relative abundance of taxa and fecal lipids. The anti-obesogenic effects of TRF in HF diets are partly due to the increase in fat excretion in the feces. Furthermore, fat content and feeding timing differentially affect the fecal microbiota and the relationship between the microbiota and fecal lipids. Full article
(This article belongs to the Special Issue The Effects of Dietary Fat on Gut Microbiota and Metabolic Health)
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Review

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43 pages, 2593 KiB  
Review
Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review
by Vicente Javier Clemente-Suárez, Ana Isabel Beltrán-Velasco, Laura Redondo-Flórez, Alexandra Martín-Rodríguez and José Francisco Tornero-Aguilera
Nutrients 2023, 15(12), 2749; https://doi.org/10.3390/nu15122749 - 14 Jun 2023
Cited by 52 | Viewed by 18876
Abstract
The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged foods, refined grains, red meat, processed meat, high-sugar drinks, candy, sweets, fried foods, conventionally raised animal products, high-fat dairy products, and high-fructose products. The present review aims to describe [...] Read more.
The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged foods, refined grains, red meat, processed meat, high-sugar drinks, candy, sweets, fried foods, conventionally raised animal products, high-fat dairy products, and high-fructose products. The present review aims to describe the effect of the Western pattern diet on the metabolism, inflammation, and antioxidant status; the impact on gut microbiota and mitochondrial fitness; the effect of on cardiovascular health, mental health, and cancer; and the sanitary cost of the Western diet. To achieve this goal, a consensus critical review was conducted using primary sources, such as scientific articles, and secondary sources, including bibliographic indexes, databases, and web pages. Scopus, Embase, Science Direct, Sports Discuss, ResearchGate, and the Web of Science were used to complete the assignment. MeSH-compliant keywords such “Western diet”, “inflammation”, “metabolic health”, “metabolic fitness”, “heart disease”, “cancer”, “oxidative stress”, “mental health”, and “metabolism” were used. The following exclusion criteria were applied: (i) studies with inappropriate or irrelevant topics, not germane to the review’s primary focus; (ii) Ph.D. dissertations, proceedings of conferences, and unpublished studies. This information will allow for a better comprehension of this nutritional behavior and its effect on an individual’s metabolism and health, as well as the impact on national sanitary systems. Finally, practical applications derived from this information are made. Full article
(This article belongs to the Special Issue The Effects of Dietary Fat on Gut Microbiota and Metabolic Health)
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